{"id":"https://openalex.org/W2017865649","doi":"https://doi.org/10.1080/15287398409530626","title":"Assessment of the delayed neurotoxic potential of isopropyl triphenylphosphate using a nontraditional testing strategy","display_name":"Assessment of the delayed neurotoxic potential of isopropyl triphenylphosphate using a nontraditional testing strategy","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2017865649","doi":"https://doi.org/10.1080/15287398409530626","mag":"2017865649","pmid":"https://pubmed.ncbi.nlm.nih.gov/6520887"},"language":"en","primary_location":{"id":"doi:10.1080/15287398409530626","doi":"https://doi.org/10.1080/15287398409530626","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398409530626","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111816217","display_name":"Gary L. Sprague","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. L. Sprague","raw_affiliation_strings":["Toxicology Department, Stauffer Chemical Company, 400 Farming\u2010ton Avenue, Farmington, Connecticut, 06032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Department, Stauffer Chemical Company, 400 Farming\u2010ton Avenue, Farmington, Connecticut, 06032","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006208452","display_name":"Thomas R. Castles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. R. Castles","raw_affiliation_strings":["Toxicology Department, Stauffer Chemical Company, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Department, Stauffer Chemical Company, Farmington, Connecticut","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112141397","display_name":"A. A. Bickford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. A. Bickford","raw_affiliation_strings":["College of Veterinary Medicine, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"14","issue":"5-6","first_page":"773","last_page":"788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delayed-neurotoxicity","display_name":"delayed neurotoxicity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/plasma-cholinesterase-inhibition","display_name":"plasma cholinesterase inhibition","score":0.859000027179718},{"id":"https://openalex.org/keywords/organophosphate-neurotoxicity","display_name":"organophosphate neurotoxicity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hens","display_name":"hens","score":0.6169999837875366},{"id":"https://openalex.org/keywords/neurohistology","display_name":"neurohistology","score":0.460999995470047},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.42800000309944153},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8963966369628906},{"id":"https://openalex.org/C104264131","wikidata":"https://www.wikidata.org/wiki/Q898637","display_name":"Isopropyl","level":2,"score":0.6880165934562683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6389809250831604},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6031265258789062},{"id":"https://openalex.org/C2780447906","wikidata":"https://www.wikidata.org/wiki/Q418573","display_name":"Triphenyl phosphate","level":3,"score":0.5703827142715454},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.5563941597938538},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5414334535598755},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.5398212671279907},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37724602222442627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3380357623100281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33020538091659546},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.2839493155479431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25847822427749634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25420960783958435},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06466871500015259},{"id":"https://openalex.org/C205474432","wikidata":"https://www.wikidata.org/wiki/Q1354051","display_name":"Fire retardant","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005411","descriptor_name":"Flame Retardants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010755","descriptor_name":"Organophosphates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014317","descriptor_name":"Tritolyl Phosphates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287398409530626","doi":"https://doi.org/10.1080/15287398409530626","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398409530626","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},{"id":"pmid:6520887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6520887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1508421599","https://openalex.org/W1546962148","https://openalex.org/W1663482440","https://openalex.org/W1775749144","https://openalex.org/W1968008618","https://openalex.org/W1971048984","https://openalex.org/W1986798789","https://openalex.org/W1997335008","https://openalex.org/W1999263401","https://openalex.org/W2003008294","https://openalex.org/W2033734515","https://openalex.org/W2062568957","https://openalex.org/W2078814771","https://openalex.org/W2093420170","https://openalex.org/W2169975019","https://openalex.org/W2315931805","https://openalex.org/W2887281572","https://openalex.org/W4240857734","https://openalex.org/W4300587822"],"related_works":["https://openalex.org/W2099147160","https://openalex.org/W2016990918","https://openalex.org/W2088057294","https://openalex.org/W2371080677","https://openalex.org/W317003222","https://openalex.org/W2094844158","https://openalex.org/W2056390465","https://openalex.org/W1967520545","https://openalex.org/W2003282689","https://openalex.org/W2002700274"],"abstract_inverted_index":{"The":[0,94,150,170],"potential":[1],"of":[2,49,60,67,78,85,109,132,145],"isopropyl":[3],"triphenyl":[4],"phosphate":[5,21,25,29,34,39,121],"(ITP)":[6],"to":[7,104,119,126,167,180],"produce":[8,112],"delayed":[9,61,79,113,134,258],"neurotoxicity":[10,62,146],"in":[11,124,201,243],"hens":[12],"was":[13,96,116,183,195,250],"examined":[14],"using":[15],"several":[16],"techniques.":[17],"ITP":[18,50,81,115,136,160,177,227],"contained":[19],"O,O,O-triphenyl":[20],"(24%),":[22],"O-o-isopropylphenyl":[23],"O,O-diphenyl":[24,33,38],"(25%),":[26],"O,O-diisopropyl-phenyl":[27],"O-phenyl":[28],"(20%),":[30],"O-o,":[31],"p-diisopropylphenyl":[32],"(18%)":[35],"and":[36,63,89,154,161,165,190,207,218],"O-p-isopropylphenyl":[37],"(6%).":[40],"Hens":[41],"treated":[42,244],"twice,":[43],"3":[44],"wk":[45],"apart,":[46],"with":[47],"doses":[48],"as":[51,53],"high":[52],"11.7":[54,181],"g/kg":[55],"showed":[56,72,225],"no":[57],"clinical":[58,239],"signs":[59,66],"only":[64],"mild":[65],"general":[68],"toxicity.":[69],"Furthermore,":[70,246],"none":[71],"even":[73],"subtle":[74],"neurohistologic":[75,241],"changes":[76],"suggestive":[77],"neurotoxicity.":[80,114,135],"produced":[82,147,175,200,211,228,255],"dose-dependent":[83],"inhibition":[84,100,158,174,194,210],"hen":[86],"plasma":[87],"cholinesterase":[88],"brain":[90,153,172,206],"neurotoxic":[91],"esterase":[92],"(NTE).":[93],"study":[95],"continued":[97],"because":[98],"NTE":[99,157,173,193,232],"has":[101],"been":[102],"shown":[103],"be":[105,168],"a":[106],"reliable":[107],"predictor":[108],"organophosphates":[110],"that":[111,199,226,254],"administered":[117],"prior":[118],"tri-o-tolyl":[120],"(TOCP)":[122],"challenge":[123],"order":[125],"determine":[127],"if":[128],"it":[129],"altered":[130],"development":[131],"TOCP":[133,162],"neither":[137],"enhanced":[138],"nor":[139],"reduced":[140],"the":[141,202,234,257],"onset":[142],"or":[143,240],"severity":[144],"by":[148,159,176,212,256],"TOCP.":[149,260],"time-course":[151],"for":[152],"spinal":[155,191,208],"cord":[156,192,209],"were":[163,216],"compared":[164],"found":[166],"different.":[169],"maximum":[171],"(doses":[178],"up":[179],"g/kg)":[182],"never":[184],"complete":[185],"(always":[186],"less":[187,197],"than":[188,198,220,253],"90%),":[189],"significantly":[196],"brain.":[203],"In":[204],"contrast,":[205],"500":[213],"mg":[214],"TOCP/kg":[215],"equal":[217],"greater":[219],"90%.":[221],"This":[222],"testing":[223],"regimen":[224],"an":[229],"effect":[230,249],"on":[231],"at":[233],"biochemical":[235,248],"level":[236],"without":[237],"producing":[238],"abnormalities":[242],"hens.":[245],"this":[247],"qualitatively":[251],"different":[252],"neurotoxicant":[259]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}