{"id":"https://openalex.org/W2017862798","doi":"https://doi.org/10.1016/s0378-4347(01)00141-4","title":"Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay \u2014 inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase","display_name":"Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay \u2014 inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2017862798","doi":"https://doi.org/10.1016/s0378-4347(01)00141-4","mag":"2017862798","pmid":"https://pubmed.ncbi.nlm.nih.gov/11419739"},"language":"en","primary_location":{"id":"doi:10.1016/s0378-4347(01)00141-4","doi":"https://doi.org/10.1016/s0378-4347(01)00141-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-4347(01)00141-4","pdf_url":null,"source":{"id":"https://openalex.org/S14366386","display_name":"Journal of Chromatography B Biomedical Sciences and Applications","issn_l":"0378-4347","issn":["0378-4347","1387-2273","1872-812X","1878-5603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B: Biomedical Sciences and Applications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051318143","display_name":"Hideki Fujino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088742","display_name":"Kowa (Japan)","ror":"https://ror.org/009z2z347","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088742"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideki Fujino","raw_affiliation_strings":["Tokyo Research Laboratories, Kowa Company Ltd., Higashimurayama, Japan","Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Research Laboratories, Kowa Company Ltd., Higashimurayama, Japan","institution_ids":["https://openalex.org/I4210088742"]},{"raw_affiliation_string":"Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan","institution_ids":["https://openalex.org/I4210088742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111690150","display_name":"Iwao Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088742","display_name":"Kowa (Japan)","ror":"https://ror.org/009z2z347","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iwao Yamada","raw_affiliation_strings":["Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan","institution_ids":["https://openalex.org/I4210088742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757222","display_name":"Syunsuke Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088742","display_name":"Kowa (Japan)","ror":"https://ror.org/009z2z347","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Syunsuke Shimada","raw_affiliation_strings":["Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan","institution_ids":["https://openalex.org/I4210088742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109924436","display_name":"Michiaki Yoneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088742","display_name":"Kowa (Japan)","ror":"https://ror.org/009z2z347","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiaki Yoneda","raw_affiliation_strings":["Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Research Laboratories, Kowa Company Ltd., Noguchicho 2-17-43, Higashimurayama, Tokyo, Japan","institution_ids":["https://openalex.org/I4210088742"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051318143"],"corresponding_institution_ids":["https://openalex.org/I4210088742"],"apc_list":null,"apc_paid":null,"fwci":0.9204,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.70643896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"757","issue":"1","first_page":"143","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.11680000275373459,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9769999980926514},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6449999809265137},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytochrome-p450-metabolism","display_name":"cytochrome P450 metabolism","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.69244784116745},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.5827106833457947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5535092949867249},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5336212515830994},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5327494144439697},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.4676969051361084},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4346122145652771},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.4297761917114258},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4258936643600464},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41858458518981934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3708052635192871},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33658039569854736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19891762733459473},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0378-4347(01)00141-4","doi":"https://doi.org/10.1016/s0378-4347(01)00141-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-4347(01)00141-4","pdf_url":null,"source":{"id":"https://openalex.org/S14366386","display_name":"Journal of Chromatography B Biomedical Sciences and Applications","issn_l":"0378-4347","issn":["0378-4347","1387-2273","1872-812X","1878-5603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B: Biomedical Sciences and Applications","raw_type":"journal-article"},{"id":"pmid:11419739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11419739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Biomedical sciences and applications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1509451141","https://openalex.org/W1816481860","https://openalex.org/W1942035808","https://openalex.org/W2004416116","https://openalex.org/W2021008707","https://openalex.org/W2034125824","https://openalex.org/W2036015501","https://openalex.org/W2069416218","https://openalex.org/W2125552807","https://openalex.org/W2133536147","https://openalex.org/W2150946709","https://openalex.org/W2154094988","https://openalex.org/W2211257844","https://openalex.org/W6733913100"],"related_works":["https://openalex.org/W2049163186","https://openalex.org/W1979262252","https://openalex.org/W2018522485","https://openalex.org/W2048188333","https://openalex.org/W1779739875","https://openalex.org/W2187614775","https://openalex.org/W2063912463","https://openalex.org/W1983276169","https://openalex.org/W2046527544","https://openalex.org/W2384412197"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
