{"id":"https://openalex.org/W2017855040","doi":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","title":"Image analysis of Nissl\u2010stained neuronal perikarya in the primary visual cortex of the rat: Automatic detection and segmentation of neuronal profiles with nuclei and nucleoli*","display_name":"Image analysis of Nissl\u2010stained neuronal perikarya in the primary visual cortex of the rat: Automatic detection and segmentation of neuronal profiles with nuclei and nucleoli*","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2017855040","doi":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","mag":"2017855040","pmid":"https://pubmed.ncbi.nlm.nih.gov/2332885"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2818.1990.tb02970.x","doi":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","pdf_url":null,"source":{"id":"https://openalex.org/S168975578","display_name":"Journal of Microscopy","issn_l":"0022-2720","issn":["0022-2720","1365-2818"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microscopy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Peter Ahrens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Ahrens","raw_affiliation_strings":["Anatomical Institute, University of Cologne, F.R.G","Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Institute, University of Cologne, F.R.G","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070715804","display_name":"Axel Schleicher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Schleicher","raw_affiliation_strings":["Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646992","display_name":"Karl Zilles","orcid":"https://orcid.org/0000-0002-4705-4175","observed_orcids":["https://orcid.org/0000-0002-4705-4175"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Zilles","raw_affiliation_strings":["Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Institute, University of Cologne, D-5000 Cologne 41, F.R.G","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111608870","display_name":"Lisa Werner","orcid":"https://orcid.org/0000-0001-9065-7839","observed_orcids":["https://orcid.org/0000-0001-9065-7839"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Werner","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, Karl-Marx-University, DDR-7022 Leipzig, G.D.R"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, Karl-Marx-University, DDR-7022 Leipzig, G.D.R","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.2023,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"157","issue":"3","first_page":"349","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nissl-staining","display_name":"Nissl staining","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neuronal-perikarya","display_name":"neuronal perikarya","score":0.8799999952316284},{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.906000018119812},{"id":"https://openalex.org/keywords/non-pyramidal-neurons","display_name":"non-pyramidal neurons","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.45500001311302185},{"id":"https://openalex.org/keywords/neuron-classification","display_name":"neuron classification","score":0.5619999766349792},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C37753355","wikidata":"https://www.wikidata.org/wiki/Q911877","display_name":"Nissl body","level":3,"score":0.9211516976356506},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.5987707376480103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5407356023788452},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5385500192642212},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5375003814697266},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5348146557807922},{"id":"https://openalex.org/C163895629","wikidata":"https://www.wikidata.org/wiki/Q3009543","display_name":"Cytoarchitecture","level":2,"score":0.5022144317626953},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.4871325194835663},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4677659869194031},{"id":"https://openalex.org/C76297474","wikidata":"https://www.wikidata.org/wiki/Q1898737","display_name":"Morphological analysis","level":2,"score":0.46759527921676636},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4328051507472992},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.4201374053955078},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40876877307891846},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3871256411075592},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.304776132106781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14809074997901917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14302781224250793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2818.1990.tb02970.x","doi":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2818.1990.tb02970.x","pdf_url":null,"source":{"id":"https://openalex.org/S168975578","display_name":"Journal of Microscopy","issn_l":"0022-2720","issn":["0022-2720","1365-2818"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microscopy","raw_type":"journal-article"},{"id":"pmid:2332885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2332885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microscopy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W111104","https://openalex.org/W590066897","https://openalex.org/W654149423","https://openalex.org/W1574651818","https://openalex.org/W1973832629","https://openalex.org/W1986282083","https://openalex.org/W1995840802","https://openalex.org/W2009790394","https://openalex.org/W2031189819","https://openalex.org/W2035171821","https://openalex.org/W2040087953","https://openalex.org/W2048412465","https://openalex.org/W2049134195","https://openalex.org/W2053115433","https://openalex.org/W2070247744","https://openalex.org/W2072521261","https://openalex.org/W2076685817","https://openalex.org/W2084189919","https://openalex.org/W2106875648","https://openalex.org/W2136256266","https://openalex.org/W2138014752","https://openalex.org/W2168950642","https://openalex.org/W2169772564","https://openalex.org/W2279313673","https://openalex.org/W2341025993","https://openalex.org/W2394648692","https://openalex.org/W4242976046","https://openalex.org/W4248397325","https://openalex.org/W4253449373","https://openalex.org/W4255444560"],"related_works":["https://openalex.org/W2172002169","https://openalex.org/W2753351808","https://openalex.org/W2547009870","https://openalex.org/W2080237158","https://openalex.org/W3021580876","https://openalex.org/W1994255547","https://openalex.org/W2885643455","https://openalex.org/W2551888419","https://openalex.org/W4243463164","https://openalex.org/W2394648692"],"abstract_inverted_index":{"An":[0],"image":[1],"analysing":[2],"procedure":[3,106,191],"for":[4,199],"the":[5,20,40,103,121,126,157,193,200],"morphometric":[6,184],"characterization":[7,185],"of":[8,19,23,44,50,54,70,102,115,118,125,145,152,163,186,196,203],"cortical":[9,45,205],"neurons":[10,119],"in":[11,120,143],"Nissl-stained":[12,204],"brain":[13],"sections":[14,86],"is":[15,192],"described.":[16],"It":[17],"consists":[18],"automatic":[21,148,201],"detection":[22],"cellular":[24],"profiles":[25,114,129,139,155],"and":[26,31,57,64,74,91,112,150,170],"their":[27],"compartments:":[28],"cytoplasm,":[29],"nucleus":[30],"nucleolus.":[32],"The":[33,100],"algorithm":[34],"was":[35,107],"designed":[36],"to":[37],"cope":[38],"with":[39,134],"large":[41,161],"morphological":[42,165],"spectrum":[43],"perikarya":[46,89],"(e.g.":[47,77],"geometrical":[48],"properties":[49],"perikarya,":[51],"staining":[52],"intensities":[53],"cell":[55],"compartments":[56],"nucleo-plasmic":[58],"area-ratio)":[59],"including":[60,167],"pyramidal":[61],"(Golgi-category":[62,66],"I)":[63],"non-pyramidal":[65],"II)":[67],"neurons.":[68,206],"Clusters":[69],"cells":[71],"were":[72,130,140],"separated":[73],"non-neuronal":[75],"structures":[76],"glia,":[78],"endothelial":[79],"cells)":[80],"as":[81,83,132],"well":[82],"tangential,":[84],"non-nucleolated":[85,113,138],"through":[87],"neuronal":[88,154,188],"recognized":[90,131],"excluded":[92],"from":[93,156],"further":[94],"analysis":[95],"without":[96],"requiring":[97],"interactive":[98],"procedures.":[99],"performance":[101],"profile":[104],"recognition":[105],"evaluated":[108],"using":[109,176],"426":[110],"nucleolated":[111,153],"different":[116,187],"types":[117],"primary":[122],"visual":[123],"cortex":[124],"rat.":[127],"Nucleolated":[128],"such":[133],"a":[135,160,197],"91%":[136],"accuracy,":[137],"rejected":[141],"correctly":[142],"90%":[144],"cases.":[146],"After":[147],"segmentation":[149],"selection":[151],"microscopic":[158],"field,":[159],"set":[162],"quantitative":[164,183],"features":[166],"geometrical,":[168],"densitometrical":[169],"textural":[171],"parameters":[172],"can":[173],"be":[174],"measured":[175],"high":[177],"power":[178],"light":[179],"microscopy.":[180],"This":[181,190],"permits":[182],"types.":[189],"first":[194],"part":[195],"system":[198],"classification":[202]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
