{"id":"https://openalex.org/W2017848448","doi":"https://doi.org/10.1016/j.ymthe.2006.08.438","title":"378. Phase I Trial of Intravenous Infusion of Onyx 015 and Enbrel in Solid Tumor Patients","display_name":"378. Phase I Trial of Intravenous Infusion of Onyx 015 and Enbrel in Solid Tumor Patients","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2017848448","doi":"https://doi.org/10.1016/j.ymthe.2006.08.438","mag":"2017848448"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2006.08.438","doi":"https://doi.org/10.1016/j.ymthe.2006.08.438","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.438","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ymthe.2006.08.438","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111917213","display_name":"Gerald M. Edelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Edelman","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111839131","display_name":"Neil N. Senzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Senzer","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113495737","display_name":"Michael Nemunaitis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Nemunaitis","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110312609","display_name":"Casey C. Cunningham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey Cunningham","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027637349","display_name":"Paige Sovern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Sovern","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alex Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Tong","raw_affiliation_strings":["Baylor University Medical Center, Baylor University Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor University Medical Center, Baylor University Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I2802366037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055054082","display_name":"John J. Nemunaitis","orcid":"https://orcid.org/0000-0002-2234-2381","observed_orcids":["https://orcid.org/0000-0002-2234-2381"]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Nemunaitis","raw_affiliation_strings":["Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Medical Research Center, Texas Oncology, PA, Mary Crowley Medical Research Center, Texas Oncology, PA, Dallas, TX","institution_ids":["https://openalex.org/I4210087725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.3074,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56066873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":null,"first_page":"S144","last_page":"S144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onyx-015","display_name":"ONYX-015","score":0.9589999914169312},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":0.8989999890327454},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/intravenous-gene-therapy","display_name":"intravenous gene therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.8370000123977661},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.5568427443504333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42707979679107666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13824203610420227},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ymthe.2006.08.438","doi":"https://doi.org/10.1016/j.ymthe.2006.08.438","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.438","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2006.08.438","doi":"https://doi.org/10.1016/j.ymthe.2006.08.438","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.438","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042351268","https://openalex.org/W2085649860","https://openalex.org/W2040976531","https://openalex.org/W2132002141","https://openalex.org/W4406709186","https://openalex.org/W2017576006","https://openalex.org/W4241415388","https://openalex.org/W2162044353","https://openalex.org/W2313228602","https://openalex.org/W1492631261"],"abstract_inverted_index":{"Onyx":[0],"015":[1],"is":[2],"an":[3,38],"E1B":[4],"deleted":[5],"conditional":[6],"replicating":[7],"adenovirus":[8],"which":[9],"has":[10],"demonstrated":[11],"control":[12],"of":[13,51],"local":[14],"regional":[15],"disease":[16],"in":[17],"prior":[18],"studies":[19],"[E.":[20],"Lin":[21],"and":[22],"J.":[23],"Nemunaitis,":[24],"Cancer":[25],"Gene":[26],"Ther":[27],"11,":[28],"643":[29],"(2004)]":[30],"but":[31],"demonstrates":[32],"limited":[33],"effect":[34],"when":[35],"administered":[36],"as":[37],"intravenous":[39],"therapeutic.":[40],"We":[41],"hypothesized":[42],"that":[43],"systemic":[44],"activity":[45],"may":[46],"be":[47],"potentiated":[48],"by":[49],"reduction":[50],"viral":[52],"clearance":[53],"related":[54],"to":[55],"tumor":[56],"necrosis":[57],"factor":[58],"a":[59],"(TNF|[alpha]|).":[60]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}