{"id":"https://openalex.org/W2017828562","doi":"https://doi.org/10.1016/j.ajpath.2013.02.025","title":"Lymphatic Vessel Memory Stimulated by Recurrent Inflammation","display_name":"Lymphatic Vessel Memory Stimulated by Recurrent Inflammation","publication_year":2013,"publication_date":"2013-04-08","ids":{"openalex":"https://openalex.org/W2017828562","doi":"https://doi.org/10.1016/j.ajpath.2013.02.025","mag":"2017828562","pmid":"https://pubmed.ncbi.nlm.nih.gov/23578386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3668023"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2013.02.025","doi":"https://doi.org/10.1016/j.ajpath.2013.02.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.02.025","pdf_url":"http://ajp.amjpathol.org/article/S0002944013002034/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ajp.amjpathol.org/article/S0002944013002034/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110106926","display_name":"Philip M. Kelley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107141","display_name":"Boys Town National Research Hospital","ror":"https://ror.org/01q9r1072","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip M. Kelley","raw_affiliation_strings":["Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA","Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA","institution_ids":["https://openalex.org/I4210107141"]},{"raw_affiliation_string":"Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska","institution_ids":["https://openalex.org/I4210107141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046919388","display_name":"Alicia L. Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107141","display_name":"Boys Town National Research Hospital","ror":"https://ror.org/01q9r1072","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia L. Connor","raw_affiliation_strings":["Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska","institution_ids":["https://openalex.org/I4210107141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065915933","display_name":"Richard M. Tempero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107141","display_name":"Boys Town National Research Hospital","ror":"https://ror.org/01q9r1072","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. Tempero","raw_affiliation_strings":["Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska","Department of Otolaryngology, Boys Town National Research Hospital, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska","institution_ids":["https://openalex.org/I4210107141"]},{"raw_affiliation_string":"Department of Otolaryngology, Boys Town National Research Hospital, Omaha, Nebraska","institution_ids":["https://openalex.org/I4210107141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065915933"],"corresponding_institution_ids":["https://openalex.org/I4210107141"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":2.6769,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8996967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"182","issue":"6","first_page":"2418","last_page":"2428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-inflammation","display_name":"recurrent inflammation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lymphatic-vessel-remodeling","display_name":"lymphatic vessel remodeling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd11b-macrophages","display_name":"CD11b+ macrophages","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":0.6480000019073486},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.7314399480819702},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7220677137374878},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5593854784965515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5226157307624817},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30554068088531494}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D039481","descriptor_name":"CD11b Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D042582","descriptor_name":"Vascular Endothelial Growth Factor C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D042583","descriptor_name":"Lymphangiogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ajpath.2013.02.025","doi":"https://doi.org/10.1016/j.ajpath.2013.02.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.02.025","pdf_url":"http://ajp.amjpathol.org/article/S0002944013002034/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3013493","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3668023","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3668023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3668023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:23578386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23578386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2013.02.025","doi":"https://doi.org/10.1016/j.ajpath.2013.02.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.02.025","pdf_url":"http://ajp.amjpathol.org/article/S0002944013002034/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2070921492","display_name":"The Molecular Biology of Neurosurgery Systems","funder_award_id":"5p20rr018788-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2864971854","display_name":null,"funder_award_id":"5P20RR018788","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4089763268","display_name":"The Molecular Biology of Neurosurgery Systems","funder_award_id":"P20GM103471","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5761260735","display_name":null,"funder_award_id":"5P20RR018788","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G578382494","display_name":null,"funder_award_id":"GM103471\u201009","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6023524611","display_name":null,"funder_award_id":"5P20RR018788\u201009","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7212834897","display_name":"INTEGRIN REGULATION OF CORNEAL LYMPHATIC VESSEL GROWTH AND REGRESSION","funder_award_id":"R01EY021571","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G839628966","display_name":null,"funder_award_id":"#P20 RR018788","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000205148","display_name":null,"funder_award_id":"5P20RR018788","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000249664","display_name":null,"funder_award_id":"5P20RR018788-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017828562.pdf","grobid_xml":"https://content.openalex.org/works/W2017828562.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1963064194","https://openalex.org/W1967415740","https://openalex.org/W1975659237","https://openalex.org/W1979345828","https://openalex.org/W1991298929","https://openalex.org/W1992532574","https://openalex.org/W2020958716","https://openalex.org/W2022280349","https://openalex.org/W2029044530","https://openalex.org/W2033388509","https://openalex.org/W2036109348","https://openalex.org/W2036825758","https://openalex.org/W2037380046","https://openalex.org/W2039199894","https://openalex.org/W2047395977","https://openalex.org/W2054969539","https://openalex.org/W2061530778","https://openalex.org/W2062240872","https://openalex.org/W2064372507","https://openalex.org/W2065957571","https://openalex.org/W2068104262","https://openalex.org/W2072172632","https://openalex.org/W2082893012","https://openalex.org/W2083621908","https://openalex.org/W2086918224","https://openalex.org/W2094807740","https://openalex.org/W2099703857","https://openalex.org/W2106340219","https://openalex.org/W2150429095","https://openalex.org/W2151213460","https://openalex.org/W2155303524","https://openalex.org/W2155901178","https://openalex.org/W2158659385","https://openalex.org/W2170625748"],"related_works":["https://openalex.org/W2167126673","https://openalex.org/W2049061647","https://openalex.org/W2022280349","https://openalex.org/W1979524315","https://openalex.org/W2003794908","https://openalex.org/W2162826750","https://openalex.org/W884037226","https://openalex.org/W2020571956","https://openalex.org/W2065114044","https://openalex.org/W1965985032"],"abstract_inverted_index":{"Inflammation":[0],"stimulates":[1],"new":[2],"lymphatic":[3,20,34,50,65,80,97,105,131,144],"vessel":[4,21,35,51,81,98,106,132,145],"growth":[5,116],"(inflammatory":[6],"lymphangiogenesis).":[7],"One":[8],"key":[9],"question":[10],"is":[11],"how":[12],"recurrent":[13,27,56],"inflammation,":[14],"a":[15,32,40,47,68,137,142,148],"common":[16],"clinical":[17],"condition,":[18],"regulates":[19],"remodeling.":[22],"We":[23],"show":[24],"here":[25],"that":[26,103,123],"inflammation":[28,63],"accelerated":[29],"the":[30,77,89,92,104,113],"development":[31,78],"functional":[33],"network.":[36],"This":[37],"observation":[38],"suggests":[39],"novel":[41],"program":[42],"of":[43,49,61,79,95,152],"lymphangiogenesis":[44,129],"and":[45,67,91,130],"identifies":[46],"property":[48],"memory":[52,107,146],"in":[53,71,88],"response":[54,108],"to":[55,140],"inflammation.":[57],"A":[58,120],"brief":[59],"episode":[60],"initial":[62],"regressed":[64],"vessels,":[66],"significant":[69],"increase":[70],"CD11b(+)":[72],"macrophages":[73],"were":[74],"associated":[75],"with":[76],"memory.":[82,133],"These":[83,134],"vessels":[84],"had":[85],"major":[86],"differences":[87],"structure":[90],"spatial":[93],"distribution":[94],"specialized":[96],"features.":[99],"Surprisingly,":[100],"we":[101],"found":[102],"did":[109],"not":[110],"depend":[111],"on":[112],"vascular":[114],"endothelial":[115],"factor":[117],"C":[118],"or":[119],"pathway,":[121],"indicating":[122],"different":[124],"molecular":[125],"pathways":[126],"regulate":[127],"inflammatory":[128],"findings":[135],"uncover":[136],"priming":[138],"mechanism":[139],"facilitate":[141],"rapid":[143],"response:":[147],"potential":[149],"important":[150],"component":[151],"peripheral":[153],"host":[154],"defense.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
