{"id":"https://openalex.org/W2017828306","doi":"https://doi.org/10.1117/12.2003830","title":"Fractal analysis of scatter imaging signatures to distinguish breast pathologies","display_name":"Fractal analysis of scatter imaging signatures to distinguish breast pathologies","publication_year":2013,"publication_date":"2013-02-21","ids":{"openalex":"https://openalex.org/W2017828306","doi":"https://doi.org/10.1117/12.2003830","mag":"2017828306"},"language":"en","primary_location":{"id":"doi:10.1117/12.2003830","doi":"https://doi.org/10.1117/12.2003830","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2003830","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10902/2513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022986459","display_name":"Alma Eguizabal","orcid":"https://orcid.org/0000-0001-8969-4253","observed_orcids":["https://orcid.org/0000-0001-8969-4253"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alma Eguizabal","raw_affiliation_strings":["Univ. de Cantabria (Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. de Cantabria (Spain)","institution_ids":["https://openalex.org/I13134134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037161741","display_name":"Ashley Marie Laughney","orcid":"https://orcid.org/0000-0001-9435-953X","observed_orcids":["https://orcid.org/0000-0001-9435-953X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley M. Laughney","raw_affiliation_strings":["Harvard Medical School at Massachusetts General Hospital (United States)","Thayer School of Engineering at Dartmouth (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School at Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Thayer School of Engineering at Dartmouth (United States)","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051690362","display_name":"Venkataramanan Krishnaswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkataramanan Krishnaswamy","raw_affiliation_strings":["Harvard Medical School at Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School at Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072764063","display_name":"Wendy A. Wells","orcid":"https://orcid.org/0000-0002-2169-481X","observed_orcids":["https://orcid.org/0000-0002-2169-481X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy A. Wells","raw_affiliation_strings":["Thayer School of Engineering at Dartmouth, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering at Dartmouth, United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016359425","display_name":"Keith D. Paulsen","orcid":"https://orcid.org/0000-0002-6692-3196","observed_orcids":["https://orcid.org/0000-0002-6692-3196"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith D. Paulsen","raw_affiliation_strings":["Dartmouth-Hitchcock Medical Ctr., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth-Hitchcock Medical Ctr., United States","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089497655","display_name":"Brian W. Pogue","orcid":"https://orcid.org/0000-0002-9887-670X","observed_orcids":["https://orcid.org/0000-0002-9887-670X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian W. Pogue","raw_affiliation_strings":["Thayer School of Engineering at Dartmouth, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering at Dartmouth, United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085018989","display_name":"Jos\u00e9 Miguel L\u00f3pez Higuera","orcid":"https://orcid.org/0000-0002-8615-8487","observed_orcids":["https://orcid.org/0000-0002-8615-8487"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. L\u00f3pez-Higuera","raw_affiliation_strings":["Univ. de Cantabria (Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. de Cantabria (Spain)","institution_ids":["https://openalex.org/I13134134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049317321","display_name":"Olga M. Conde","orcid":"https://orcid.org/0000-0002-2471-3051","observed_orcids":["https://orcid.org/0000-0002-2471-3051"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga M. Conde","raw_affiliation_strings":["Univ. de Cantabria (Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. de Cantabria (Spain)","institution_ids":["https://openalex.org/I13134134"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5938,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79520345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8592","issue":null,"first_page":"85920Y","last_page":"85920Y"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractal-analysis","display_name":"fractal analysis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fractal-dimension","display_name":"fractal dimension","score":0.9369999766349792},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6769999861717224},{"id":"https://openalex.org/keywords/principal-components","display_name":"principal components","score":0.722000002861023},{"id":"https://openalex.org/keywords/intraoperative-diagnosis","display_name":"intraoperative diagnosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C40636538","wikidata":"https://www.wikidata.org/wiki/Q81392","display_name":"Fractal","level":2,"score":0.6502358913421631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.648772120475769},{"id":"https://openalex.org/C162494671","wikidata":"https://www.wikidata.org/wiki/Q2845227","display_name":"Fractal analysis","level":4,"score":0.49054068326950073},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.46575814485549927},{"id":"https://openalex.org/C2777432617","wikidata":"https://www.wikidata.org/wiki/Q22905905","display_name":"Breast imaging","level":5,"score":0.4547249376773834},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44484901428222656},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34317272901535034},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.32464277744293213},{"id":"https://openalex.org/C26546657","wikidata":"https://www.wikidata.org/wiki/Q1412452","display_name":"Fractal dimension","level":3,"score":0.27543243765830994},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1790587604045868},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1378714144229889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08086138963699341},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07997328042984009},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2003830","doi":"https://doi.org/10.1117/12.2003830","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2003830","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:repositorio.unican.es:10902/2513","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10902/2513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of SPIE, 2013, vol. 8592, 85920Y","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:repositorio.unican.es:10902/2513","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10902/2513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of SPIE, 2013, vol. 8592, 85920Y","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"display_name":"Peace, justice, and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.550000011920929}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W566370799","https://openalex.org/W1984103681","https://openalex.org/W1987813948","https://openalex.org/W1999085280","https://openalex.org/W2035004052","https://openalex.org/W2067420088","https://openalex.org/W2069964245","https://openalex.org/W2071350591","https://openalex.org/W2113667317","https://openalex.org/W2125614842","https://openalex.org/W2130746306","https://openalex.org/W2140741294","https://openalex.org/W2144349513","https://openalex.org/W2146263616"],"related_works":["https://openalex.org/W2415593857","https://openalex.org/W2544539966","https://openalex.org/W2751503712","https://openalex.org/W3092133550","https://openalex.org/W2377772528","https://openalex.org/W2085917061","https://openalex.org/W4379660995","https://openalex.org/W1991834834","https://openalex.org/W3158254474","https://openalex.org/W2146263616"],"abstract_inverted_index":{"Fractal":[0,81],"analysis":[1,40,82,102,171],"combined":[2],"with":[3,151,191],"a":[4,47,55,109,116,121,213],"label-free":[5],"scattering":[6,105,139],"technique":[7],"is":[8,65,135,149,161],"proposed":[9],"for":[10],"describing":[11],"the":[12,43,51,58,87,90,97,104,138,152,156,164,188,201,206],"pathological":[13],"architecture":[14],"of":[15,34,38,45,50,57,89,99,155,172,180,203],"tumors.":[16],"Clinicians":[17],"and":[18,61,69,112,128,141,145,209],"pathologists":[19],"are":[20],"conventionally":[21],"trained":[22],"to":[23,78,103,216],"classify":[24],"abnormal":[25],"features":[26],"such":[27],"as":[28,212],"structural":[29],"irregularities":[30],"or":[31],"high":[32],"indices":[33],"mitosis.":[35],"The":[36,158],"potential":[37],"fractal":[39,101,147,159,170,181,189],"lies":[41],"in":[42,71,86,132,200,205],"fact":[44],"being":[46],"morphometric":[48],"measure":[49,56,74],"irregular":[52],"structures":[53],"providing":[54],"object\u2019s":[59],"complexity":[60],"self-similarity.":[62],"As":[63],"cancer":[64],"characterized":[66],"by":[67,120],"disorder":[68],"irregularity":[70,127],"tissues,":[72],"this":[73],"could":[75,184],"be":[76],"related":[77],"tumor":[79,91],"growth.":[80],"has":[83],"been":[84],"probed":[85],"understanding":[88],"vasculature":[92],"network.":[93],"This":[94,195],"work":[95],"addresses":[96],"feasibility":[98],"applying":[100,163],"power":[106,140],"map":[107],"(as":[108,115],"physical":[110],"modeling)":[111,118],"principal":[113,142],"components":[114,143],"statistical":[117],"provided":[119],"localized":[122],"reflectance":[123],"spectroscopic":[124],"system.":[125],"Disorder,":[126],"cell":[129],"size":[130],"variation":[131],"tissue":[133,175],"samples":[134,176],"translated":[136],"into":[137],"magnitude":[144],"its":[146],"dimension":[148,160,182],"correlated":[150],"pathologist":[153],"assessment":[154],"samples.":[157],"computed":[162],"box-counting":[165],"technique.":[166],"Results":[167],"show":[168],"that":[169,183],"ex-vivo":[173],"fresh":[174],"exhibits":[177],"separated":[178],"ranges":[179],"help":[185,199],"classifier":[186],"combining":[187],"results":[190],"other":[192],"morphological":[193],"features.":[194],"contrast":[196],"trend":[197],"would":[198],"discrimination":[202],"tissues":[204],"intraoperative":[207],"context":[208],"may":[210],"serve":[211],"useful":[214],"adjunct":[215],"surgeons.":[217]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}