{"id":"https://openalex.org/W2017818649","doi":"https://doi.org/10.1016/0223-5234(92)90011-o","title":"Synth\u00e8se de d\u00e9riv\u00e9s de la 2-thio hydanto\u00efne \u00e0 potentialit\u00e9 immunor\u00e9gulatrice et anticanc\u00e9reuse","display_name":"Synth\u00e8se de d\u00e9riv\u00e9s de la 2-thio hydanto\u00efne \u00e0 potentialit\u00e9 immunor\u00e9gulatrice et anticanc\u00e9reuse","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2017818649","doi":"https://doi.org/10.1016/0223-5234(92)90011-o","mag":"2017818649"},"language":"fr","primary_location":{"id":"doi:10.1016/0223-5234(92)90011-o","doi":"https://doi.org/10.1016/0223-5234(92)90011-o","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(92)90011-o","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111991953","display_name":"Madeleine Blanc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144972","display_name":"Laboratoire de Chimie Organique","ror":"https://ror.org/04db3be62","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210144972","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Blanc","raw_affiliation_strings":["Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France","institution_ids":["https://openalex.org/I4210144972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011206854","display_name":"M Cussac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M Cussac","raw_affiliation_strings":["Laboratoire de Chimie Th\u00e9rapeutique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Th\u00e9rapeutique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38700 La Tronche, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090013490","display_name":"Andr\u00e9 Boucherle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144972","display_name":"Laboratoire de Chimie Organique","ror":"https://ror.org/04db3be62","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210144972","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Boucherle","raw_affiliation_strings":["Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France","institution_ids":["https://openalex.org/I4210144972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112449405","display_name":"G. LECLERC","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144972","display_name":"Laboratoire de Chimie Organique","ror":"https://ror.org/04db3be62","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210144972","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G Leclerc","raw_affiliation_strings":["Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Organique, Groupe de Pharmacochimie Mol\u00e9culaire, Facult\u00e9 de Pharmacie, 38240 Meylan, France","institution_ids":["https://openalex.org/I4210144972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011206854"],"corresponding_institution_ids":[],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.6386,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.617191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"27","issue":"3","first_page":"267","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13304","display_name":"Synthesis and Reactivity of Sulfur-Containing Compounds","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chronic-inflammatory-diseases","display_name":"chronic inflammatory diseases","score":0.8339999914169312},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9130444526672363},{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.7373210787773132},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.5298295617103577},{"id":"https://openalex.org/C2781253882","wikidata":"https://www.wikidata.org/wiki/Q770860","display_name":"Thio-","level":2,"score":0.510206937789917},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36411887407302856},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35741090774536133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34215047955513},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30997592210769653},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11387652158737183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0223-5234(92)90011-o","doi":"https://doi.org/10.1016/0223-5234(92)90011-o","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(92)90011-o","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1022095743","https://openalex.org/W1490063475","https://openalex.org/W1969510504","https://openalex.org/W1974167134","https://openalex.org/W1988080603","https://openalex.org/W2025444976","https://openalex.org/W2027318182","https://openalex.org/W2028124023","https://openalex.org/W2059192125","https://openalex.org/W2141603878","https://openalex.org/W2144885876","https://openalex.org/W2317033225","https://openalex.org/W2342151268","https://openalex.org/W4236126995","https://openalex.org/W4249935050"],"related_works":["https://openalex.org/W1994841434","https://openalex.org/W2036339717","https://openalex.org/W2998043877","https://openalex.org/W650153961","https://openalex.org/W2949464469","https://openalex.org/W589430848","https://openalex.org/W2951864793","https://openalex.org/W1982376527","https://openalex.org/W2187418140","https://openalex.org/W2931906082"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}