{"id":"https://openalex.org/W2017797475","doi":"https://doi.org/10.1016/j.provac.2013.06.007","title":"Adjuvant Formulations Designed to Improve Swine Vaccine Stability: Application to PCV2 Vaccines","display_name":"Adjuvant Formulations Designed to Improve Swine Vaccine Stability: Application to PCV2 Vaccines","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2017797475","doi":"https://doi.org/10.1016/j.provac.2013.06.007","mag":"2017797475"},"language":"en","primary_location":{"id":"doi:10.1016/j.provac.2013.06.007","doi":"https://doi.org/10.1016/j.provac.2013.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.provac.2013.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S128067432","display_name":"Procedia in Vaccinology","issn_l":"1877-282X","issn":["1877-282X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia in Vaccinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.provac.2013.06.007","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057177890","display_name":"Juliette Ben Arous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267296","display_name":"SEPPIC (France)","ror":"https://ror.org/022s7wx37","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267296"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Ben Arous","raw_affiliation_strings":["SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France","institution_ids":["https://openalex.org/I4405267296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103480443","display_name":"Fran\u00e7ois Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267296","display_name":"SEPPIC (France)","ror":"https://ror.org/022s7wx37","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267296"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Bertrand","raw_affiliation_strings":["SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France","institution_ids":["https://openalex.org/I4405267296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111585115","display_name":"J\u00e9r\u00f4me Gaucheron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267296","display_name":"SEPPIC (France)","ror":"https://ror.org/022s7wx37","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267296"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Gaucheron","raw_affiliation_strings":["SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France","institution_ids":["https://openalex.org/I4405267296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077789012","display_name":"Oleg A. Verkhovsky","orcid":"https://orcid.org/0000-0003-0784-9341","observed_orcids":["https://orcid.org/0000-0003-0784-9341"]},"institutions":[{"id":"https://openalex.org/I4210090755","display_name":"Diagnostic and Prevention Research Institute for Human and Animal Diseases","ror":"https://ror.org/00ag0hf75","country_code":"RU","type":"nonprofit","lineage":["https://openalex.org/I4210090755"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O.A. Verkhovsky","raw_affiliation_strings":["\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia","institution_ids":["https://openalex.org/I4210090755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113815036","display_name":"A.P. Kotelnikov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090755","display_name":"Diagnostic and Prevention Research Institute for Human and Animal Diseases","ror":"https://ror.org/00ag0hf75","country_code":"RU","type":"nonprofit","lineage":["https://openalex.org/I4210090755"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.P. Kotelnikov","raw_affiliation_strings":["\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia","institution_ids":["https://openalex.org/I4210090755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008782569","display_name":"E. V. Shemelkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090755","display_name":"Diagnostic and Prevention Research Institute for Human and Animal Diseases","ror":"https://ror.org/00ag0hf75","country_code":"RU","type":"nonprofit","lineage":["https://openalex.org/I4210090755"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.V. Shemelkov","raw_affiliation_strings":["\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia","institution_ids":["https://openalex.org/I4210090755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007511075","display_name":"Konstantin P. Alekseev","orcid":"https://orcid.org/0000-0001-9536-3127","observed_orcids":["https://orcid.org/0000-0001-9536-3127"]},"institutions":[{"id":"https://openalex.org/I4210090755","display_name":"Diagnostic and Prevention Research Institute for Human and Animal Diseases","ror":"https://ror.org/00ag0hf75","country_code":"RU","type":"nonprofit","lineage":["https://openalex.org/I4210090755"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K.P. Alekseev","raw_affiliation_strings":["\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cDiagnostic and Prevention Research Institute for Human and Animal Diseases\u201d (DPRI), Moscow, Russia","institution_ids":["https://openalex.org/I4210090755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063648180","display_name":"Laurent Dupuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267296","display_name":"SEPPIC (France)","ror":"https://ror.org/022s7wx37","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267296"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Dupuis","raw_affiliation_strings":["SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SEPPIC, 22 Terrasse Bellini, Paris La D\u00e9fense, 92806 Puteaux Cedex, France","institution_ids":["https://openalex.org/I4405267296"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"34","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-circovirus-type-2","display_name":"porcine circovirus type 2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pcv2-vaccine","display_name":"PCV2 vaccine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/vaccine-stability","display_name":"vaccine stability","score":0.8360000252723694},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.6489999890327454},{"id":"https://openalex.org/keywords/oil-in-water-adjuvant","display_name":"oil-in-water adjuvant","score":0.8360000252723694},{"id":"https://openalex.org/keywords/vaccine-formulation","display_name":"vaccine formulation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2781045504","wikidata":"https://www.wikidata.org/wiki/Q128578","display_name":"Porcine circovirus","level":3,"score":0.9047009944915771},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7254893183708191},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6729152798652649},{"id":"https://openalex.org/C2779231742","wikidata":"https://www.wikidata.org/wiki/Q5121560","display_name":"Circovirus","level":4,"score":0.5079966187477112},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49148643016815186},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.48920488357543945},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47982048988342285},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.45210713148117065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4139508903026581},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31229665875434875},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.16236689686775208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.provac.2013.06.007","doi":"https://doi.org/10.1016/j.provac.2013.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.provac.2013.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S128067432","display_name":"Procedia in Vaccinology","issn_l":"1877-282X","issn":["1877-282X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia in Vaccinology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.provac.2013.06.007","doi":"https://doi.org/10.1016/j.provac.2013.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.provac.2013.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S128067432","display_name":"Procedia in Vaccinology","issn_l":"1877-282X","issn":["1877-282X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia in Vaccinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1985121469","https://openalex.org/W2008735853","https://openalex.org/W2014628841","https://openalex.org/W2035406498","https://openalex.org/W2072892746","https://openalex.org/W2090698640","https://openalex.org/W2221203277"],"related_works":["https://openalex.org/W2372699191","https://openalex.org/W2350157365","https://openalex.org/W4296764268","https://openalex.org/W1191711079","https://openalex.org/W2588963031","https://openalex.org/W2737394499","https://openalex.org/W7045596529","https://openalex.org/W2171685075","https://openalex.org/W7004700331","https://openalex.org/W2955433995"],"abstract_inverted_index":{"Porcine":[0],"circovirus":[1,15],"associated":[2],"diseases":[3,8],"(PCVADs)":[4],"are":[5,65,118],"economically":[6],"important":[7,45],"of":[9,77],"domestic":[10],"pigs":[11],"caused":[12],"by":[13],"porcine":[14],"type":[16],"2":[17],"(PCV2).":[18],"PCV2":[19,36,48,53],"vaccination":[20,71],"is":[21,29,51,83],"usually":[22],"performed":[23],"with":[24,47],"adjuvanted":[25],"inactivated":[26],"formulations":[27,99],"and":[28,34,80,110,127,133],"necessary":[30,84],"to":[31,74,85,120,122],"control":[32],"PCVADs":[33],"subclinical":[35],"related":[37],"body":[38],"weight":[39],"losses":[40],"in":[41,69,108],"pig":[42],"farming.":[43],"An":[44],"issue":[46],"vaccine":[49,61,78,90],"formulation":[50],"that":[52,96],"antigenic":[54,125],"media":[55,126],"often":[56],"have":[57],"properties":[58,76],"which":[59],"destabilize":[60],"formulations.":[62],"Vaccine":[63],"adjuvants":[64,117],"a":[66],"key":[67],"parameter":[68],"modern":[70],"closely":[72],"linked":[73],"galenic":[75,81],"formulations,":[79],"stability":[82,88],"insure":[86],"efficacy":[87,134],"during":[89],"shelf":[91],"life.":[92],"Here":[93],"we":[94],"show":[95],"especially":[97],"designed":[98],"based":[100],"on":[101],"Montanide":[102,111],"TM":[103,112],"ISA":[104],"11R":[105],"VG":[106],"(Oil":[107],"water)":[109],"ESSAI":[113],"Gel":[114],"R":[115],"(polymer)":[116],"able":[119],"resist":[121],"very":[123],"destabilizing":[124],"conditions":[128],"while":[129],"keeping":[130],"safety":[131],"parameters":[132],"at":[135],"requested":[136],"levels.":[137]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2016-06-24T00:00:00"}