{"id":"https://openalex.org/W2017783641","doi":"https://doi.org/10.1210/endo-127-4-1580","title":"A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*","display_name":"A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2017783641","doi":"https://doi.org/10.1210/endo-127-4-1580","mag":"2017783641","pmid":"https://pubmed.ncbi.nlm.nih.gov/1698143"},"language":"en","primary_location":{"id":"doi:10.1210/endo-127-4-1580","doi":"https://doi.org/10.1210/endo-127-4-1580","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-127-4-1580","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017783641"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110164924","display_name":"Yasuhiro Sako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"YASUHIRO SAKO","raw_affiliation_strings":["Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090090811","display_name":"Valdemar Grill","orcid":"https://orcid.org/0000-0001-6959-022X","observed_orcids":["https://orcid.org/0000-0001-6959-022X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"VALDEMAR E. GRILL","raw_affiliation_strings":["Department of Endocrinology, Karolinska Hospital Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Karolinska Hospital Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1335113835"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.4126,"has_fulltext":false,"cited_by_count":371,"citation_normalized_percentile":{"value":0.91965982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"127","issue":"4","first_page":"1580","last_page":"1589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intralipid","display_name":"Intralipid","score":0.7120000123977661},{"id":"https://openalex.org/keywords/lipid-infusion","display_name":"lipid infusion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.75},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.5680000185966492},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.6320000290870667},{"id":"https://openalex.org/keywords/glucose-oxidation","display_name":"glucose oxidation","score":0.36800000071525574},{"id":"https://openalex.org/keywords/carnitine-palmitoyltransferase-1","display_name":"carnitine palmitoyltransferase 1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/etomoxir","display_name":"etomoxir","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8863720297813416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8625102043151855},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7174250483512878},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5624940395355225},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.541694164276123},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4784541130065918},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4726093113422394},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.45275118947029114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4453330636024475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32898569107055664},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28070706129074097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2751900553703308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09846675395965576}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002334","descriptor_name":"Carnitine O-Palmitoyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005217","descriptor_name":"Fat Emulsions, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-127-4-1580","doi":"https://doi.org/10.1210/endo-127-4-1580","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-127-4-1580","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:1698143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1698143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W811315364","https://openalex.org/W1500111450","https://openalex.org/W1507372364","https://openalex.org/W1633034930","https://openalex.org/W1966660296","https://openalex.org/W1979721410","https://openalex.org/W1994088876","https://openalex.org/W1997114752","https://openalex.org/W2006154786","https://openalex.org/W2012898950","https://openalex.org/W2014505438","https://openalex.org/W2053531586","https://openalex.org/W2054293703","https://openalex.org/W2068406450","https://openalex.org/W2072656195","https://openalex.org/W2073299209","https://openalex.org/W2078073869","https://openalex.org/W2078176355","https://openalex.org/W2078221365","https://openalex.org/W2079717789","https://openalex.org/W2096217291","https://openalex.org/W2097884696","https://openalex.org/W2100624249","https://openalex.org/W2130200187","https://openalex.org/W2151212771","https://openalex.org/W2157865424","https://openalex.org/W2159000141","https://openalex.org/W2163216300","https://openalex.org/W2164917301","https://openalex.org/W2318009091","https://openalex.org/W2466994925"],"related_works":["https://openalex.org/W2042637405","https://openalex.org/W2162261303","https://openalex.org/W2017935763","https://openalex.org/W2069971581","https://openalex.org/W2072890036","https://openalex.org/W1972230452","https://openalex.org/W2159896083","https://openalex.org/W1993480864","https://openalex.org/W2038131372","https://openalex.org/W2110774736"],"abstract_inverted_index":{"Short-":[0],"and":[1,21,193,283,288],"long-term":[2],"effects":[3],"of":[4,32,55,63,116,140,177,264],"hyperlipidemia":[5],"with":[6,24,152,191,256],"elevated":[7],"FFA":[8],"on":[9,273],"insulin":[10,66,117,154,266],"secretion":[11,161,205,240],"were":[12,17,110,113,183,189],"investigated.":[13],"Male":[14],"Sprague-Dawley":[15],"rats":[16,138],"fed":[18],"ad":[19],"libitum":[20],"additionally":[22],"infused":[23,137,190],"Intralipid":[25,33,56,64],"10%,":[26],"1.0":[27],"ml/h.":[28],"After":[29,52,60],"3":[30],"h":[31,54,62,135,180],"the":[34,153,234],"response":[35,155],"to":[36,79,95,156,169,218,233,241,253,279],"27":[37,157],"mM":[38,99,103,107,158],"glucose":[39,224,281],"in":[40,150,166],"isolated":[41,131],"perfused":[42,207],"pancreas":[43,208],"was":[44,68,91,144,162,195],"enhanced":[45,196],"by":[46,70,165,197],"86%,":[47],"P":[48,86,227,246],"less":[49,87,147,228,247],"than":[50,88,148,229,248],"0.02.":[51,89],"6":[53],"enhancement":[57],"had":[58],"subsided.":[59],"48":[61,134,179],"glucose-induced":[65,204,239,265],"release":[67],"inhibited":[69,238],"49%,":[71],"from":[72,133,142,206,209],"1950":[73],"+/-":[74,81,119,125,211,220,243],"177":[75],"microU/min":[76,83,213,222],"after":[77,84,122,128,214,223],"saline":[78,215],"1003":[80],"232":[82],"Intralipid,":[85,231],"Inhibition":[90],"glucose-selective":[92],"since":[93],"responses":[94],"other":[96],"secretagogues":[97],"(1":[98],"3-isobutyl-1":[100],"methylxanthine,":[101],"10":[102],"octanoate,":[104],"or":[105],"5":[106],"alpha-ketoisocaproic":[108],"acid)":[109],"unaffected":[111],"as":[112],"pancreatic":[114],"contents":[115],"(2284":[118],"111":[120],"mU/pancreas":[121,127],"saline,":[123],"2566":[124],"131":[126],"Intralipid).":[129],"In":[130],"islets":[132],"lipid":[136,181],"production":[139],"[14-C]CO2":[141],"D[U-14-C]glucose":[143],"decreased":[145,280],"(P":[146],"0.02)":[149],"parallel":[151],"glucose.":[159],"Glucose-induced":[160],"partially":[163],"normalized":[164],"vitro":[167],"exposure":[168],"a":[170,178],"carnitine":[171],"palmitoyl-transferase":[172],"I":[173],"inhibitor":[174],"(Etomoxir).":[175],"Effects":[176],"infusion":[182],"also":[184],"tested":[185],"during":[186,286],"hyperglycemia.":[187,289],"Rats":[188],"glucose,":[192],"hyperglycemia":[194],"dexamethasone":[198,217],"(25":[199],"micrograms/24":[200],"h).":[201],"Hyperglycemia":[202],"depressed":[203],"2072":[210],"22":[212],"+":[216,225],"1185":[219],"155":[221],"dexamethasone,":[226],"0.01).":[230],"added":[232],"latter":[235],"protocol,":[236],"further":[237],"437":[242],"87":[244],"microU/min,":[245],"0.005.":[249],"Hyperlipidemia":[250],"is":[251,277],"concluded":[252],"be":[254],"associated":[255],"short":[257],"term":[258,262],"stimulation":[259],"but":[260],"long":[261],"inhibition":[263,271],"secretion.":[267],"Evidence":[268],"indicates":[269],"that":[270],"depends":[272],"fatty":[274],"acid":[275],"oxidation,":[276],"coupled":[278],"oxidation":[282],"operates":[284],"both":[285],"normo-":[287]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
