{"id":"https://openalex.org/W2017760463","doi":"https://doi.org/10.1016/j.coi.2013.05.012","title":"Humanized mice for the study of infectious diseases","display_name":"Humanized mice for the study of infectious diseases","publication_year":2013,"publication_date":"2013-06-08","ids":{"openalex":"https://openalex.org/W2017760463","doi":"https://doi.org/10.1016/j.coi.2013.05.012","mag":"2017760463","pmid":"https://pubmed.ncbi.nlm.nih.gov/23751490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3775881"},"language":"en","primary_location":{"id":"doi:10.1016/j.coi.2013.05.012","doi":"https://doi.org/10.1016/j.coi.2013.05.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2013.05.012","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3775881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023032912","display_name":"Michael A. Brehm","orcid":"https://orcid.org/0000-0001-6813-3262","observed_orcids":["https://orcid.org/0000-0001-6813-3262"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Brehm","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025171436","display_name":"Nathalie Jouvet","orcid":"https://orcid.org/0000-0001-9675-2319","observed_orcids":["https://orcid.org/0000-0001-9675-2319"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathalie Jouvet","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634163","display_name":"Dale L. Greiner","orcid":"https://orcid.org/0000-0002-5923-339X","observed_orcids":["https://orcid.org/0000-0002-5923-339X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale L Greiner","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonard D Shultz","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, United States","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036394378"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":1.7681,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.85853207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"25","issue":"4","first_page":"428","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epidemic-modeling","display_name":"epidemic modeling","score":0.6259999871253967},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.8289999961853027},{"id":"https://openalex.org/keywords/drug-efficacy-evaluation","display_name":"drug efficacy evaluation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.6210470199584961},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5672442317008972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5383383631706238},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5080208778381348},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46435001492500305},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.46078813076019287},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4586683511734009},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.44129252433776855},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.41911664605140686},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3452568054199219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2835724949836731},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1967569887638092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16761574149131775},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13990342617034912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10212984681129456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08679807186126709}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.coi.2013.05.012","doi":"https://doi.org/10.1016/j.coi.2013.05.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2013.05.012","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},{"id":"pmid:23751490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23751490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3775881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3775881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Immunol","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:faculty_pubs-1382","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/faculty_pubs/383","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Massachusetts Medical School Faculty Publications","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:stfb2013-1076","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2013/77","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2013","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3775881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3775881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2677314950","display_name":null,"funder_award_id":"DK 32520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G311143156","display_name":null,"funder_award_id":"CA-034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5864376598","display_name":"Diabetes Endocrinology Research Center (DERC)","funder_award_id":"P30DK032520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6543545613","display_name":"Viral Infection Influence on Transplantation Tolerance","funder_award_id":"P01AI046629","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6981198605","display_name":"UMASS Center for AIDS Research (CFAR)","funder_award_id":"P30AI042845","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7840458255","display_name":null,"funder_award_id":"AI-046629","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000110905","display_name":null,"funder_award_id":"DK32520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000207431","display_name":null,"funder_award_id":"AI046629","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W115528016","https://openalex.org/W177107166","https://openalex.org/W208435926","https://openalex.org/W1516044117","https://openalex.org/W1535549793","https://openalex.org/W1537342340","https://openalex.org/W1958692210","https://openalex.org/W1965228684","https://openalex.org/W1968873679","https://openalex.org/W1969100298","https://openalex.org/W1969379511","https://openalex.org/W1969938511","https://openalex.org/W1970910239","https://openalex.org/W1974096769","https://openalex.org/W1977282539","https://openalex.org/W1979504042","https://openalex.org/W1980422180","https://openalex.org/W1984295407","https://openalex.org/W1984823254","https://openalex.org/W1985434613","https://openalex.org/W1985918910","https://openalex.org/W1989877475","https://openalex.org/W1993365997","https://openalex.org/W1999253174","https://openalex.org/W2002987798","https://openalex.org/W2010519150","https://openalex.org/W2012150396","https://openalex.org/W2016613470","https://openalex.org/W2021586066","https://openalex.org/W2024123171","https://openalex.org/W2025835234","https://openalex.org/W2027451953","https://openalex.org/W2031332141","https://openalex.org/W2038363431","https://openalex.org/W2041515126","https://openalex.org/W2046560815","https://openalex.org/W2053006144","https://openalex.org/W2055077060","https://openalex.org/W2055601403","https://openalex.org/W2063082418","https://openalex.org/W2072764395","https://openalex.org/W2073489229","https://openalex.org/W2081020320","https://openalex.org/W2083208889","https://openalex.org/W2089085102","https://openalex.org/W2090356138","https://openalex.org/W2096860032","https://openalex.org/W2097705840","https://openalex.org/W2099789019","https://openalex.org/W2100929788","https://openalex.org/W2100943457","https://openalex.org/W2101669500","https://openalex.org/W2102090977","https://openalex.org/W2102514367","https://openalex.org/W2104407049","https://openalex.org/W2109590624","https://openalex.org/W2109963121","https://openalex.org/W2131112023","https://openalex.org/W2137879329","https://openalex.org/W2137906256","https://openalex.org/W2139050492","https://openalex.org/W2145254159","https://openalex.org/W2145533822","https://openalex.org/W2146145483","https://openalex.org/W2146288137","https://openalex.org/W2153130425","https://openalex.org/W2155796970","https://openalex.org/W2157908499","https://openalex.org/W2159465679","https://openalex.org/W2161771297","https://openalex.org/W2166045197","https://openalex.org/W4254002014"],"related_works":["https://openalex.org/W2512821830","https://openalex.org/W2415744702","https://openalex.org/W2789627020","https://openalex.org/W1500818418","https://openalex.org/W2001128436","https://openalex.org/W3186394360","https://openalex.org/W2260371678","https://openalex.org/W2013355638","https://openalex.org/W3170165946","https://openalex.org/W3214320141"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}