{"id":"https://openalex.org/W2017758139","doi":"https://doi.org/10.1021/bi0474620","title":"Time Course and Site(s) of Cytochrome c Tyrosine Nitration by Peroxynitrite","display_name":"Time Course and Site(s) of Cytochrome c Tyrosine Nitration by Peroxynitrite","publication_year":2005,"publication_date":"2005-05-12","ids":{"openalex":"https://openalex.org/W2017758139","doi":"https://doi.org/10.1021/bi0474620","mag":"2017758139","pmid":"https://pubmed.ncbi.nlm.nih.gov/15924423"},"language":"en","primary_location":{"id":"doi:10.1021/bi0474620","doi":"https://doi.org/10.1021/bi0474620","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0474620","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063685695","display_name":"Carlos Batthy\u00e1ny","orcid":"https://orcid.org/0000-0002-0627-1982","observed_orcids":["https://orcid.org/0000-0002-0627-1982"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Carlos Batthy\u00e1ny","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056557213","display_name":"Jos\u00e9 M. Souza","orcid":"https://orcid.org/0009-0001-2144-6621","observed_orcids":["https://orcid.org/0009-0001-2144-6621"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Souza","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045811942","display_name":"Rosario Dur\u00e1n","orcid":"https://orcid.org/0000-0002-8575-9651","observed_orcids":["https://orcid.org/0000-0002-8575-9651"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Rosario Dur\u00e1n","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067681170","display_name":"Adriana Cassina","orcid":"https://orcid.org/0000-0002-3409-9235","observed_orcids":["https://orcid.org/0000-0002-3409-9235"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Adriana Cassina","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005891093","display_name":"Carlos \u010cerve\u00f1ansk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Carlos Cerve\u00f1ansky","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay, and Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073926538"],"corresponding_institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.2627,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.92400122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"44","issue":"22","first_page":"8038","last_page":"8046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.09009999781847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosine-nitration","display_name":"tyrosine nitration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.996999979019165},{"id":"https://openalex.org/keywords/peroxidase-activity","display_name":"peroxidase activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tetranitromethane","display_name":"tetranitromethane","score":0.9200000166893005},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8117915391921997},{"id":"https://openalex.org/C2777337673","wikidata":"https://www.wikidata.org/wiki/Q412241","display_name":"Tetranitromethane","level":3,"score":0.8027418255805969},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.7597013711929321},{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.7470254302024841},{"id":"https://openalex.org/C2775856698","wikidata":"https://www.wikidata.org/wiki/Q909607","display_name":"Nitration","level":2,"score":0.7356642484664917},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6757497191429138},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.551264226436615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.514204740524292},{"id":"https://openalex.org/C133166286","wikidata":"https://www.wikidata.org/wiki/Q3678325","display_name":"Cytochrome c peroxidase","level":4,"score":0.5063909292221069},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41778242588043213},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.23800131678581238},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.1752317249774933},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1329706907272339},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12834396958351135}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011190","descriptor_name":"Potassium Cyanide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012966","descriptor_name":"Sodium Cyanide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013774","descriptor_name":"Tetranitromethane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi0474620","doi":"https://doi.org/10.1021/bi0474620","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0474620","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:15924423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15924423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W411383580","https://openalex.org/W1532078988","https://openalex.org/W1662237934","https://openalex.org/W1725300350","https://openalex.org/W1943182047","https://openalex.org/W1968378905","https://openalex.org/W1968473228","https://openalex.org/W2009279488","https://openalex.org/W2010106046","https://openalex.org/W2063968553","https://openalex.org/W2071858285","https://openalex.org/W2073444730","https://openalex.org/W2079125529","https://openalex.org/W2084602044","https://openalex.org/W2122028337","https://openalex.org/W2137729619","https://openalex.org/W2149307297","https://openalex.org/W4232534952"],"related_works":["https://openalex.org/W5792924","https://openalex.org/W2009279488","https://openalex.org/W7208149874","https://openalex.org/W2010106046","https://openalex.org/W2015884929","https://openalex.org/W2003108616","https://openalex.org/W7095114540","https://openalex.org/W2046398732","https://openalex.org/W2107823353","https://openalex.org/W3138017939"],"abstract_inverted_index":{"Cytochrome":[0,20],"c-dependent":[1],"electron":[2],"transfer":[3],"and":[4,16,34,42,54,62,127,134,153,157,159,164,177,188,203,205,255,258],"apoptosome":[5],"activation":[6],"require":[7],"protein-protein":[8],"binding,":[9],"which":[10],"are":[11],"mainly":[12],"directed":[13],"by":[14,46,71,85,131],"conformational":[15],"specific":[17,272],"electrostatic":[18],"interactions.":[19],"c":[21,52,70,83,123,146,191,200,228,261,276,282],"contains":[22],"four":[23],"highly":[24],"conserved":[25],"tyrosine":[26,65,142],"residues,":[27],"one":[28,31],"internal":[29],"(Tyr67),":[30],"intermediate":[32],"(Tyr48),":[33],"two":[35,120],"more":[36],"accessible":[37],"to":[38,183,206,214,237,265],"the":[39,59,95,107,116,168,180,216,230,267,291],"solvent":[40],"(Tyr74":[41],"Tyr97).":[43],"Tyrosine":[44],"nitration":[45,66,224,247,270,283],"biologically-relevant":[47],"intermediates":[48],"could":[49],"influence":[50,268],"cytochrome":[51,69,82,122,145,190,199,220,227,260,275,281],"structure":[53],"function.":[55],"Herein,":[56],"we":[57],"analyzed":[58],"time":[60],"course":[61],"site(s)":[63],"of":[64,73,78,92,98,114,167,219,226,232,253,269,271,280,294],"in":[67,144,174,201,210,229,274,285,289],"horse":[68],"fluxes":[72],"peroxynitrite.":[74],"Also,":[75],"a":[76,207],"method":[77],"purifying":[79],"each":[80],"(nitrated)":[81],"product":[84],"cation-exchange":[86],"HPLC":[87],"was":[88,212,235],"developed.":[89],"A":[90],"flux":[91],"peroxynitrite":[93],"caused":[94],"time-dependent":[96],"formation":[97],"different":[99],"nitrated":[100],"species,":[101],"all":[102,141],"less":[103],"positively":[104],"charged":[105],"than":[106],"native":[108],"form.":[109],"At":[110,138],"low":[111],"accumulated":[112],"doses":[113],"peroxynitrite,":[115,241],"main":[117],"products":[118],"were":[119,147],"mononitrated":[121],"species":[124,176,192,262],"at":[125,249],"Tyr97":[126,152],"Tyr74,":[128,163],"as":[129],"shown":[130],"peptide":[132],"mapping":[133],"mass":[135],"spectrometry":[136],"analysis.":[137],"higher":[139],"doses,":[140],"residues":[143],"nitrated,":[148],"including":[149],"dinitrated":[150,175,259],"(i.e.,":[151,161],"Tyr67":[154,171],"or":[155],"Tyr74":[156,202],"Tyr67)":[158,165],"trinitrated":[160,189],"Tyr97,":[162,211],"forms":[166],"protein,":[169],"with":[170,240,243],"well":[172],"represented":[173],"Tyr48":[178],"being":[179],"least":[181],"prone":[182],"nitration.":[184],"All":[185],"mono-,":[186],"di-,":[187],"displayed":[193],"an":[194,244],"increased":[195,245],"peroxidase":[196],"activity.":[197],"Nitrated":[198],"Tyr67,":[204],"lesser":[208],"extent":[209],"unable":[213],"restore":[215],"respiratory":[217],"function":[218],"c-depleted":[221],"mitochondria.":[222],"The":[223,251],"pattern":[225],"presence":[231],"tetranitromethane":[233],"(TNM)":[234],"comparable":[236],"that":[238],"obtained":[239],"but":[242],"relative":[246],"yield":[248],"Tyr67.":[250],"use":[252],"purified":[254],"well-characterized":[256],"mono-":[257],"allows":[263],"us":[264],"study":[266],"tyrosines":[273],"functions.":[277],"Moreover,":[278],"identification":[279],"sites":[284],"vivo":[286],"may":[287],"assist":[288],"unraveling":[290],"chemical":[292],"nature":[293],"proximal":[295],"reactive":[296],"nitrogen":[297],"species.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}