{"id":"https://openalex.org/W2017757683","doi":"https://doi.org/10.1085/jgp.62.4.375","title":"Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase","display_name":"Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase","publication_year":1973,"publication_date":"1973-10-01","ids":{"openalex":"https://openalex.org/W2017757683","doi":"https://doi.org/10.1085/jgp.62.4.375","mag":"2017757683","pmid":"https://pubmed.ncbi.nlm.nih.gov/4755846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2226121"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.62.4.375","doi":"https://doi.org/10.1085/jgp.62.4.375","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.62.4.375","pdf_url":"https://rupress.org/jgp/article-pdf/62/4/375/1245513/375.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jgp/article-pdf/62/4/375/1245513/375.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112201747","display_name":"Clay M. Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clay M. Armstrong","raw_affiliation_strings":["From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","the Marine Biological Laboratory, Woods Hole, Massachusetts 02543"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"the Marine Biological Laboratory, Woods Hole, Massachusetts 02543","institution_ids":["https://openalex.org/I1338920048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028939983","display_name":"Francisco Bezanilla","orcid":"https://orcid.org/0000-0002-6663-7931","observed_orcids":["https://orcid.org/0000-0002-6663-7931"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Bezanilla","raw_affiliation_strings":["From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","the Marine Biological Laboratory, Woods Hole, Massachusetts 02543"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"the Marine Biological Laboratory, Woods Hole, Massachusetts 02543","institution_ids":["https://openalex.org/I1338920048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103478177","display_name":"Eduardo Rojas","orcid":"https://orcid.org/0009-0007-3347-3268","observed_orcids":["https://orcid.org/0009-0007-3347-3268"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Rojas","raw_affiliation_strings":["From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","the Marine Biological Laboratory, Woods Hole, Massachusetts 02543"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Rochester, School of Medicine, Rochester, New York 14642; the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; and the Laboratorio de Fisiologi\u0301a Celular, Montemar, Chile","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"the Marine Biological Laboratory, Woods Hole, Massachusetts 02543","institution_ids":["https://openalex.org/I1338920048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.1232,"has_fulltext":true,"cited_by_count":538,"citation_normalized_percentile":{"value":0.98704496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"62","issue":"4","first_page":"375","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-channel-inactivation","display_name":"sodium channel inactivation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pronase","display_name":"pronase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/sodium-conductance","display_name":"sodium conductance","score":0.7020000219345093},{"id":"https://openalex.org/keywords/squid-giant-axon","display_name":"squid giant axon","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inactivation-gate","display_name":"inactivation gate","score":0.6499999761581421},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/sodium-channel-activation","display_name":"sodium channel activation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.953000009059906},{"id":"https://openalex.org/keywords/voltage-dependence","display_name":"voltage dependence","score":0.515999972820282},{"id":"https://openalex.org/keywords/channel-selectivity","display_name":"channel selectivity","score":0.37700000405311584},{"id":"https://openalex.org/keywords/membrane-currents","display_name":"membrane currents","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2776708817","wikidata":"https://www.wikidata.org/wiki/Q4380751","display_name":"Pronase","level":4,"score":0.9853381514549255},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6234501004219055},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5430689454078674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5412577390670776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42329251766204834},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.39800330996513367},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29956963658332825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2955395579338074},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.1582689881324768},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011402","descriptor_name":"Pronase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011402","descriptor_name":"Pronase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011402","descriptor_name":"Pronase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049832","descriptor_name":"Decapodiformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049832","descriptor_name":"Decapodiformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049832","descriptor_name":"Decapodiformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1085/jgp.62.4.375","doi":"https://doi.org/10.1085/jgp.62.4.375","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.62.4.375","pdf_url":"https://rupress.org/jgp/article-pdf/62/4/375/1245513/375.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2226121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2226121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:4755846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4755846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1085/jgp.62.4.375","doi":"https://doi.org/10.1085/jgp.62.4.375","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.62.4.375","pdf_url":"https://rupress.org/jgp/article-pdf/62/4/375/1245513/375.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.5199999809265137,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017757683.pdf","grobid_xml":"https://content.openalex.org/works/W2017757683.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1985940938","https://openalex.org/W1991379958","https://openalex.org/W1991851546","https://openalex.org/W1997458421","https://openalex.org/W1997821739","https://openalex.org/W1999483147","https://openalex.org/W1999770834","https://openalex.org/W2002784943","https://openalex.org/W2004800104","https://openalex.org/W2008778537","https://openalex.org/W2014671743","https://openalex.org/W2016448112","https://openalex.org/W2018923440","https://openalex.org/W2021538110","https://openalex.org/W2028274352","https://openalex.org/W2036101429","https://openalex.org/W2037831670","https://openalex.org/W2038227313","https://openalex.org/W2066509635","https://openalex.org/W2068546892","https://openalex.org/W2079157916","https://openalex.org/W2120659521","https://openalex.org/W2128121034","https://openalex.org/W2130106174","https://openalex.org/W2148311628","https://openalex.org/W2344179126","https://openalex.org/W2398410876","https://openalex.org/W2441164940","https://openalex.org/W6816753860"],"related_works":["https://openalex.org/W7099641426","https://openalex.org/W2008778537","https://openalex.org/W2119925335","https://openalex.org/W2071151793","https://openalex.org/W2734854364","https://openalex.org/W2025141399","https://openalex.org/W1989104065","https://openalex.org/W1990819719","https://openalex.org/W2112571943","https://openalex.org/W2091257282"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,6,11,21,30,35,72,94,98,113,124,143,153,164,174],"effects":[4],"of":[5,14,20,29,37,71,77,97,152,177,189],"proteolytic":[7],"enzyme":[8,114],"Pronase":[9,24,41,64],"on":[10],"membrane":[12],"currents":[13],"voltage-clamped":[15],"squid":[16],"axons.":[17],"Internal":[18],"perfusion":[19],"axons":[22],"with":[23],"rather":[25],"selectively":[26],"destroys":[27],"inactivation":[28,54,79,144,151,165,188],"Na":[31,82,99,154,179,190,197],"conductance":[32],"(g(Na)).":[33],"At":[34],"level":[36],"a":[38,81,134,168],"single":[39],"channel,":[40],"probably":[42],"acts":[43],"in":[44,120,133],"an":[45],"all-or-none":[46],"manner:":[47],"each":[48,178],"channel":[49,83,100],"inactivates":[50],"normally":[51],"until":[52],"its":[53,78],"gate":[55,80,166],"is":[56,110,167,182],"destroyed,":[57],"and":[58,93,108,187,195],"then":[59],"it":[60,109],"no":[61,85],"longer":[62,86],"inactivates.":[63],"reduces":[65],"g(Na),":[66],"possibly":[67],"by":[68,106,137],"destroying":[69],"some":[70],"channels,":[73],"but":[74],"after":[75],"removal":[76],"seems":[84],"vulnerable":[87],"to":[88,158,173],"Pronase.":[89,138,159],"The":[90],"turn-off":[91],"kinetics":[92],"voltage":[95],"dependence":[96],"activation":[101,129,186],"gates":[102,119,130,145],"are":[103,131,192,199],"not":[104,116,141],"affected":[105,132],"Pronase,":[107,147],"probable":[111],"that":[112,163,185,196],"does":[115,140,149],"affect":[117],"these":[118],"any":[121],"way.":[122],"Neither":[123],"K":[125,202],"channels":[126,155,191,198],"nor":[127,148],"their":[128],"specific":[135],"way":[136],"Tetrodotoxin":[139],"protect":[142],"from":[146,201],"maintained":[150],"during":[156],"exposure":[157],"Our":[160],"results":[161],"suggest":[162],"readily":[169],"accessible":[170],"protein":[171],"attached":[172],"inner":[175],"end":[176],"channel.":[180],"It":[181],"shown":[183],"clearly":[184],"separable":[193],"processes,":[194],"distinct":[200],"channels.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}