{"id":"https://openalex.org/W2017754570","doi":"https://doi.org/10.1271/bbb.67.1292","title":"Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture ofHericium erinaceus","display_name":"Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture ofHericium erinaceus","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2017754570","doi":"https://doi.org/10.1271/bbb.67.1292","mag":"2017754570","pmid":"https://pubmed.ncbi.nlm.nih.gov/12843656"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.67.1292","doi":"https://doi.org/10.1271/bbb.67.1292","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.67.1292","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041144848","display_name":"Byung-Keun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Keun YANG","raw_affiliation_strings":["Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University, Kyungsan, Kyungbuk 712-714, South Korea","Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University, Kyungsan, Kyungbuk 712-714, South Korea","institution_ids":["https://openalex.org/I9323808"]},{"raw_affiliation_string":"Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036734686","display_name":"Jun-Bo Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun-Bo PARK","raw_affiliation_strings":["Mega Biotech Co. Bonli-dong 1217-4, Dalseo-gu, Daegu 704-120, South Korea","Mega Biotech Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mega Biotech Co. Bonli-dong 1217-4, Dalseo-gu, Daegu 704-120, South Korea","institution_ids":[]},{"raw_affiliation_string":"Mega Biotech Co","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575914","display_name":"Chi\u2010Hyun Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chi-Hyun SONG","raw_affiliation_strings":["Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University Kyungsan, Kyungbuk 712-714, South Korea","Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University Kyungsan, Kyungbuk 712-714, South Korea","institution_ids":["https://openalex.org/I9323808"]},{"raw_affiliation_string":"Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University","institution_ids":["https://openalex.org/I9323808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.3858,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.63349131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"67","issue":"6","first_page":"1292","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hericium-erinaceus","display_name":"Hericium erinaceus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8889999985694885},{"id":"https://openalex.org/keywords/atherogenic-index","display_name":"atherogenic index","score":0.9390000104904175},{"id":"https://openalex.org/keywords/edible-mushroom-extracts","display_name":"edible mushroom extracts","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2778636629","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Biopolymer","level":3,"score":0.9366551637649536},{"id":"https://openalex.org/C2777545159","wikidata":"https://www.wikidata.org/wiki/Q19737","display_name":"Hericium erinaceus","level":3,"score":0.8718340992927551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7260262966156006},{"id":"https://openalex.org/C133479454","wikidata":"https://www.wikidata.org/wiki/Q326228","display_name":"Mycelium","level":2,"score":0.6463529467582703},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.637498140335083},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6006299257278442},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6004400849342346},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5246113538742065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44234901666641235},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.24632331728935242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15868842601776123},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12749499082565308},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000363","descriptor_name":"Agaricales","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D000363","descriptor_name":"Agaricales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025282","descriptor_name":"Mycelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.67.1292","doi":"https://doi.org/10.1271/bbb.67.1292","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.67.1292","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:12843656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12843656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W403614499","https://openalex.org/W1585291923","https://openalex.org/W1775749144","https://openalex.org/W1850775144","https://openalex.org/W1925422014","https://openalex.org/W1943281726","https://openalex.org/W1968834637","https://openalex.org/W1978810288","https://openalex.org/W2007784092","https://openalex.org/W2009731515","https://openalex.org/W2010255585","https://openalex.org/W2017731369","https://openalex.org/W2019182166","https://openalex.org/W2026582922","https://openalex.org/W2032131424","https://openalex.org/W2062068406","https://openalex.org/W2074923554","https://openalex.org/W2116404316","https://openalex.org/W2119754462","https://openalex.org/W2129438071","https://openalex.org/W2151602225","https://openalex.org/W2159401417","https://openalex.org/W2168526937","https://openalex.org/W2186512751","https://openalex.org/W2324761579","https://openalex.org/W2465595328","https://openalex.org/W2517229729","https://openalex.org/W3023429312","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2309825760","https://openalex.org/W2333332499","https://openalex.org/W2119754462","https://openalex.org/W2402339582","https://openalex.org/W7097618555","https://openalex.org/W2091950791","https://openalex.org/W2032131424","https://openalex.org/W4294030610","https://openalex.org/W2142922193","https://openalex.org/W2009731515"],"abstract_inverted_index":{"The":[0,36,83,106],"hypolipidemic":[1],"effect":[2],"of":[3,12,30,41,86,112],"an":[4],"exo-biopolymer":[5,32,88,114],"produced":[6],"from":[7],"a":[8],"submerged":[9],"mycelial":[10],"culture":[11],"Hericium":[13],"erinaceus":[14],"was":[15,92],"investigated":[16],"in":[17,117],"dietary-induced":[18],"hyperlipidemic":[19],"rats.":[20],"Hypolipidemic":[21],"effects":[22],"were":[23,101,115],"proportionally":[24],"increased":[25,70],"with":[26],"the":[27,31,39,48,71,80,113],"increasing":[28],"concentration":[29],"for":[33],"oral":[34],"administration.":[35],"exo-biopolymer,":[37],"at":[38],"dose":[40],"200":[42],"mg/kg":[43],"body":[44],"weight,":[45],"substantially":[46],"reduced":[47],"plasma":[49,72],"total":[50],"cholesterol":[51,54,74],"(32.9%),":[52],"LDL":[53],"(45.4%),":[55],"triglyceride":[56],"(34.3%),":[57],"phospholipid":[58],"(18.9%),":[59],"atherogenic":[60],"index":[61],"(58.7%),":[62],"and":[63,98,103,108],"hepatic":[64],"HMG-CoA":[65],"reductase":[66],"activity":[67],"(20.2%).":[68],"It":[69],"HDL":[73],"level":[75],"(31.1%)":[76],"as":[77],"compared":[78],"to":[79],"control":[81],"group.":[82],"molecular":[84],"mass":[85],"this":[87],"measured":[89],"by":[90],"HPLC":[91],"under":[93],"40":[94],"kDa.":[95],"Total":[96],"sugar":[97,107],"protein":[99],"contents":[100],"91.2":[102],"8.8%,":[104],"respectively.":[105],"amino":[109],"acid":[110],"compositions":[111],"analyzed":[116],"detail.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}