{"id":"https://openalex.org/W2017754448","doi":"https://doi.org/10.1371/journal.pone.0031253","title":"Amyloid-Like Fibril Formation by PolyQ Proteins: A Critical Balance between the PolyQ Length and the Constraints Imposed by the Host Protein","display_name":"Amyloid-Like Fibril Formation by PolyQ Proteins: A Critical Balance between the PolyQ Length and the Constraints Imposed by the Host Protein","publication_year":2012,"publication_date":"2012-03-09","ids":{"openalex":"https://openalex.org/W2017754448","doi":"https://doi.org/10.1371/journal.pone.0031253","mag":"2017754448","pmid":"https://pubmed.ncbi.nlm.nih.gov/22438863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305072"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0031253","doi":"https://doi.org/10.1371/journal.pone.0031253","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0031253","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031253&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031253&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037260134","display_name":"Natacha Scarafone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Natacha Scarafone","raw_affiliation_strings":["Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018898034","display_name":"Coralie Pain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Coralie Pain","raw_affiliation_strings":["Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022769585","display_name":"Anthony FRATAMICO","orcid":"https://orcid.org/0000-0001-7711-3212","observed_orcids":["https://orcid.org/0000-0001-7711-3212"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anthony Fratamico","raw_affiliation_strings":["Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003642599","display_name":"Gilles Gaspard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gilles Gaspard","raw_affiliation_strings":["Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071252143","display_name":"Nursel Yilmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nursel Yilmaz","raw_affiliation_strings":["Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070954948","display_name":"Patrice Fil\u00e9e","orcid":"https://orcid.org/0000-0001-6523-1537","observed_orcids":["https://orcid.org/0000-0001-6523-1537"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patrice Fil\u00e9e","raw_affiliation_strings":["Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007548667","display_name":"Moreno Galleni","orcid":"https://orcid.org/0000-0003-0992-0391","observed_orcids":["https://orcid.org/0000-0003-0992-0391"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Moreno Galleni","raw_affiliation_strings":["Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Macromolecules, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077537529","display_name":"Andr\u00e9 Matagne","orcid":"https://orcid.org/0000-0001-6417-6791","observed_orcids":["https://orcid.org/0000-0001-6417-6791"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Matagne","raw_affiliation_strings":["Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005338547","display_name":"Mireille Dumoulin","orcid":"https://orcid.org/0000-0002-4310-4622","observed_orcids":["https://orcid.org/0000-0002-4310-4622","https://orcid.org/0000-0001-6470-120X"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Mireille Dumoulin","raw_affiliation_strings":["Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering, Institute of Chemistry, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005338547"],"corresponding_institution_ids":["https://openalex.org/I157674565"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.9712,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68897011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e31253","last_page":"e31253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyglutamine-diseases","display_name":"polyglutamine diseases","score":0.9200000166893005},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/protein-chimeras","display_name":"protein chimeras","score":0.7730000019073486},{"id":"https://openalex.org/keywords/protein-destabilization","display_name":"protein destabilization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6299999952316284},{"id":"https://openalex.org/keywords/conformational-restriction","display_name":"conformational restriction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5559999942779541},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.7605479955673218},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6264641284942627},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.6060982346534729},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5831314921379089},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5756704807281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5693343281745911},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.5338284969329834},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.5031301379203796},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4874610900878906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4270079433917999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31173229217529297},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.1881977915763855},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0031253","doi":"https://doi.org/10.1371/journal.pone.0031253","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0031253","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031253&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:22438863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22438863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3305072","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3305072/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.2278","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.2278","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8f/b2/PLoS_One_2012_Mar_9_7(3)_e31253.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3f7b315967bb4b17a7ea6dfedd289c44","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f7b315967bb4b17a7ea6dfedd289c44","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e31253 (2012)","raw_type":"article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/127974","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/127974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 7 (3) (2012-03)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0031253","doi":"https://doi.org/10.1371/journal.pone.0031253","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0031253","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031253&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334840","display_name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017754448.pdf","grobid_xml":"https://content.openalex.org/works/W2017754448.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1530510651","https://openalex.org/W1564193520","https://openalex.org/W1787342943","https://openalex.org/W1820504647","https://openalex.org/W1861263514","https://openalex.org/W1967015107","https://openalex.org/W1968072183","https://openalex.org/W1970434234","https://openalex.org/W1970456057","https://openalex.org/W1974014096","https://openalex.org/W1977733590","https://openalex.org/W1978773812","https://openalex.org/W1981155219","https://openalex.org/W1981162097","https://openalex.org/W1982138826","https://openalex.org/W1982915416","https://openalex.org/W1985474993","https://openalex.org/W1985836613","https://openalex.org/W1985850661","https://openalex.org/W1993791286","https://openalex.org/W1996565611","https://openalex.org/W1996789718","https://openalex.org/W2000250831","https://openalex.org/W2001299005","https://openalex.org/W2006298998","https://openalex.org/W2012850328","https://openalex.org/W2030753289","https://openalex.org/W2030985020","https://openalex.org/W2032255653","https://openalex.org/W2032897815","https://openalex.org/W2034226945","https://openalex.org/W2034516179","https://openalex.org/W2037126504","https://openalex.org/W2038263678","https://openalex.org/W2039376206","https://openalex.org/W2041669759","https://openalex.org/W2042204511","https://openalex.org/W2046132401","https://openalex.org/W2058470791","https://openalex.org/W2067644428","https://openalex.org/W2069607465","https://openalex.org/W2072201545","https://openalex.org/W2076406620","https://openalex.org/W2077449710","https://openalex.org/W2079250951","https://openalex.org/W2079726930","https://openalex.org/W2079778346","https://openalex.org/W2089629318","https://openalex.org/W2092442034","https://openalex.org/W2096601751","https://openalex.org/W2108570063","https://openalex.org/W2112134907","https://openalex.org/W2113072432","https://openalex.org/W2113998330","https://openalex.org/W2115970730","https://openalex.org/W2126704241","https://openalex.org/W2141583055","https://openalex.org/W2148188765","https://openalex.org/W2153807318","https://openalex.org/W2159168476","https://openalex.org/W2161487209","https://openalex.org/W2162057703","https://openalex.org/W2162710350","https://openalex.org/W2170998869","https://openalex.org/W2171596398","https://openalex.org/W2313778491","https://openalex.org/W4388314258","https://openalex.org/W6857897301"],"related_works":["https://openalex.org/W2253850934","https://openalex.org/W2260156171","https://openalex.org/W1556021488","https://openalex.org/W832191440","https://openalex.org/W7010536116","https://openalex.org/W2274630829","https://openalex.org/W2237653326","https://openalex.org/W2231187861","https://openalex.org/W969920949","https://openalex.org/W55209905"],"abstract_inverted_index":{"Nine":[0],"neurodegenerative":[1],"disorders,":[2],"called":[3],"polyglutamine":[4],"(polyQ)":[5],"diseases,":[6,175],"are":[7,36],"characterized":[8],"by":[9,16,47,92],"the":[10,43,52,55,76,80,86,108,117,127,135,139,146,152,156,171,185,193,201,211,233,237,243,250,261,264,275,278,282,293],"formation":[11,229],"of":[12,32,54,66,75,82,88,95,100,110,121,126,149,155,181,236,263,277,285],"intranuclear":[13],"amyloid-like":[14,166,189,198,216,227],"aggregates":[15,29,214],"nine":[17],"proteins":[18,57,172,288],"containing":[19,195],"a":[20,24,40,72,93,178],"polyQ":[21,49,64,128,140,251,286,298],"tract":[22,266],"above":[23,183],"threshold":[25,179,224],"length.":[26],"These":[27,253,271],"insoluble":[28],"and/or":[30,245],"some":[31],"their":[33],"soluble":[34],"precursors":[35],"thought":[37],"to":[38,102,132,138,145,170,249,267],"play":[39],"role":[41],"in":[42],"pathogenesis.":[44],"The":[45,98,119,223],"mechanism":[46],"which":[48,184],"expansions":[50],"trigger":[51,268],"aggregation":[53],"relevant":[56],"remains,":[58],"however,":[59,114,256],"unclear.":[60],"In":[61],"this":[62],"work,":[63],"tracts":[65],"different":[67],"lengths":[68],"were":[69,90],"inserted":[70],"into":[71,188,215],"solvent-exposed":[73],"loop":[74],"\u03b2-lactamase":[77,238],"BlaP":[78,89,150,205,220],"and":[79,142,162,240],"effects":[81,136],"these":[83],"insertions":[84],"on":[85,151,232,242,260,281],"properties":[87,154,284],"investigated":[91],"range":[94],"biophysical":[96],"techniques.":[97],"insertion":[99],"up":[101],"79":[103],"glutamines":[104,182],"does":[105],"not":[106],"modify":[107],"structure":[109],"BlaP;":[111],"it":[112],"does,":[113],"significantly":[115],"destabilize":[116],"enzyme.":[118],"extent":[120],"destabilization":[122],"is":[123,177,206,221],"largely":[124],"independent":[125],"length,":[129],"allowing":[130],"us":[131],"study":[133],"independently":[134],"intrinsic":[137],"length":[141],"those":[143],"related":[144],"structural":[147,234],"integrity":[148,235],"aggregating":[153,283],"chimeras.":[157],"Only":[158],"chimeras":[159,186],"with":[160,174],"55Q":[161,212],"79Q":[163,196,265],"readily":[164],"form":[165],"fibrils;":[167],"therefore,":[168,231],"similarly":[169],"associated":[173],"there":[176],"number":[180],"aggregate":[187],"fibrils.":[190],"Most":[191],"importantly,":[192],"chimera":[194,213],"forms":[197],"fibrils":[199,217],"at":[200],"same":[202],"rate":[203],"whether":[204],"folded":[207],"or":[208],"not,":[209],"whereas":[210],"only":[218],"if":[219],"unfolded.":[222],"value":[225],"for":[226],"fibril":[228,269],"depends,":[230],"moiety":[239],"thus":[241],"steric":[244],"conformational":[246],"constraints":[247,254],"applied":[248],"tract.":[252],"have,":[255],"no":[257],"significant":[258],"effect":[259],"propensity":[262],"formation.":[270],"results":[272],"suggest":[273],"that":[274],"influence":[276],"protein":[279],"context":[280],"disease-associated":[287],"could":[289],"be":[290],"negligible":[291],"when":[292],"latter":[294],"contain":[295],"particularly":[296],"long":[297],"tracts.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
