{"id":"https://openalex.org/W2017752097","doi":"https://doi.org/10.1097/01.sap.0000264887.30392.72","title":"Human Shaped Thumb Bone Tissue Engineered by Hydrogel-\u03b2-Tricalciumphosphate/Poly-\u03b5-Caprolactone Scaffolds and Magnetically Sorted Stem Cells","display_name":"Human Shaped Thumb Bone Tissue Engineered by Hydrogel-\u03b2-Tricalciumphosphate/Poly-\u03b5-Caprolactone Scaffolds and Magnetically Sorted Stem Cells","publication_year":2007,"publication_date":"2007-06-15","ids":{"openalex":"https://openalex.org/W2017752097","doi":"https://doi.org/10.1097/01.sap.0000264887.30392.72","mag":"2017752097","pmid":"https://pubmed.ncbi.nlm.nih.gov/17589259"},"language":"en","primary_location":{"id":"doi:10.1097/01.sap.0000264887.30392.72","doi":"https://doi.org/10.1097/01.sap.0000264887.30392.72","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.sap.0000264887.30392.72","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078469390","display_name":"Christian Weinand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christian Weinand","raw_affiliation_strings":["Laboratory for Tissue Engineering and Organ Fabrication, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA","Laboratory for Tissue Engineering and Organ Fabrication and \u2020Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Tissue Engineering and Organ Fabrication, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Laboratory for Tissue Engineering and Organ Fabrication and \u2020Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601447","display_name":"Rajiv Gupta","orcid":"https://orcid.org/0000-0002-5882-960X","observed_orcids":["https://orcid.org/0000-0002-5882-960X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajiv Gupta","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048693420","display_name":"Eli J. Weinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Weinberg","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088384076","display_name":"Ijad Madisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ijad Madisch","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006373658","display_name":"Jesse Bernard Jupiter","orcid":"https://orcid.org/0000-0003-2846-7959","observed_orcids":["https://orcid.org/0000-0003-2846-7959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jesse B. Jupiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109572012","display_name":"Joseph Phillip Vacanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph P. Vacanti","raw_affiliation_strings":["Laboratory for Tissue Engineering and Organ Fabrication and \u2020Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Tissue Engineering and Organ Fabrication and \u2020Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078469390","https://openalex.org/A5109572012"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.1343,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76463343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"1","first_page":"46","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cd133-cells","display_name":"CD133+ cells","score":0.7889999747276306},{"id":"https://openalex.org/keywords/magnetic-activated-cell-sorting","display_name":"magnetic cell separation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/collagen-i-hydrogel","display_name":"collagen I hydrogel","score":0.9110000133514404},{"id":"https://openalex.org/keywords/beta-tcp","display_name":"beta-tricalcium phosphate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.984000027179718},{"id":"https://openalex.org/keywords/3d-printed-porous-scaffolds","display_name":"3D-printed porous scaffolds","score":0.9200000166893005},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/osteoconductivity","display_name":"osteoconductivity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nude-mouse-implantation","display_name":"nude mouse implantation","score":0.625},{"id":"https://openalex.org/keywords/biomechanical-analysis","display_name":"biomechanical analysis","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.7547838687896729},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.634034276008606},{"id":"https://openalex.org/C2781472170","wikidata":"https://www.wikidata.org/wiki/Q1410780","display_name":"Fibrin glue","level":2,"score":0.6177427768707275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6085038781166077},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6018885970115662},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4578714370727539},{"id":"https://openalex.org/C2776881184","wikidata":"https://www.wikidata.org/wiki/Q83360","display_name":"Thumb","level":2,"score":0.434267520904541},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.42761683464050293},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35833990573883057},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.356914758682251},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3011922240257263},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27651041746139526},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002130","descriptor_name":"Calcium Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002208","descriptor_name":"Caproates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D013933","descriptor_name":"Thumb","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015718","descriptor_name":"Fibrin Tissue Adhesive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.sap.0000264887.30392.72","doi":"https://doi.org/10.1097/01.sap.0000264887.30392.72","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.sap.0000264887.30392.72","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},{"id":"pmid:17589259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17589259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of plastic surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W144801377","https://openalex.org/W582655470","https://openalex.org/W1934145781","https://openalex.org/W1979505150","https://openalex.org/W1986809303","https://openalex.org/W1995455900","https://openalex.org/W2010476316","https://openalex.org/W2010533049","https://openalex.org/W2011628763","https://openalex.org/W2014853792","https://openalex.org/W2029314207","https://openalex.org/W2031294181","https://openalex.org/W2039583786","https://openalex.org/W2040699295","https://openalex.org/W2042951897","https://openalex.org/W2045355173","https://openalex.org/W2049550331","https://openalex.org/W2053780932","https://openalex.org/W2059442046","https://openalex.org/W2061702719","https://openalex.org/W2069039237","https://openalex.org/W2076089358","https://openalex.org/W2084243000","https://openalex.org/W2084479143","https://openalex.org/W2093066616","https://openalex.org/W2100060418","https://openalex.org/W2103116614","https://openalex.org/W2144621439","https://openalex.org/W2159999899","https://openalex.org/W2163181043","https://openalex.org/W2176884341","https://openalex.org/W2257324588","https://openalex.org/W2323204611","https://openalex.org/W2410797264"],"related_works":["https://openalex.org/W6964899481","https://openalex.org/W2076089358","https://openalex.org/W4230479597","https://openalex.org/W3093117820","https://openalex.org/W2325653224","https://openalex.org/W1979215889","https://openalex.org/W2068952590","https://openalex.org/W2365120645","https://openalex.org/W2003122418","https://openalex.org/W2056969104"],"abstract_inverted_index":{"Traumatic":[0],"amputation":[1],"of":[2,25,72,106,141],"a":[3,9,35,41,73,104],"thumb":[4,43,75],"with":[5,84,115,146,171],"bone":[6,44,61,76,94,154,162],"loss":[7],"leaves":[8],"patient":[10],"in":[11,56,69,91,159],"severe":[12,26],"disability.":[13],"Reconstructive":[14],"procedures":[15],"are":[16],"restricted":[17],"by":[18],"limited":[19],"shape":[20,71],"and":[21,63,80,108,112,117,136,178],"have":[22],"the":[23,70],"disadvantage":[24],"donor-site":[27],"morbidity.":[28],"To":[29],"overcome":[30],"these":[31],"limitations,":[32],"we":[33],"used":[34],"tissue":[36,165,169],"engineering":[37],"approach":[38],"to":[39],"create":[40],"distal":[42,74],"phalanx,":[45],"combining":[46],"magnetically":[47],"sorted":[48],"133+":[49,148,173],"human":[50],"mesenchymal":[51],"stem":[52],"cells":[53],"(hMSCs)":[54],"suspended":[55,85,118],"successful":[57],"tested":[58],"hydrogels":[59,83,116,145],"for":[60,93,126],"formation":[62,95,140],"porous":[64,179],"3-dimensionally":[65],"printed":[66],"scaffolds":[67,152],"(3DP)":[68],"phalanx.":[77],"Collagen":[78,156],"I":[79,157,176],"fibrin":[81],"glue":[82],"hMSCs":[86,149],"were":[87,120],"first":[88],"histologically":[89],"evaluated":[90],"vitro":[92],"after":[96],"6":[97],"weeks.":[98,128],"Then":[99],"3DP":[100,151,180],"scaffolds,":[101],"made":[102],"from":[103],"mix":[105],"osteoinductive":[107],"-conductive":[109],"beta-tricalciumphosphate":[110],"(beta-TCP)":[111],"poly-epsilon-caprolactone":[113],"(PCL),":[114],"hMSCs,":[119,174],"implanted":[121],"into":[122],"nude":[123],"mice":[124],"subcutaneously":[125],"15":[127],"Histologic":[129],"evaluation,":[130],"high-resolution":[131],"volumetric":[132],"CT":[133],"(VCT)":[134],"scanning,":[135],"biomechanical":[137],"testing":[138],"confirmed":[139],"bonelike":[142],"tissue.":[143],"Both":[144],"CD":[147,172],"on":[150],"supported":[153],"formation.":[155,163],"resulted":[158],"radiologically":[160],"better":[161],"Bone":[164],"can":[166],"be":[167],"successfully":[168],"engineered":[170],"collagen":[175],"hydrogels,":[177],"beta-TCP/PCL":[181],"scaffolds.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}