{"id":"https://openalex.org/W2017746032","doi":"https://doi.org/10.4199/c00067ed1v01y201210isp037","title":"Alveolar Structure and Function","display_name":"Alveolar Structure and Function","publication_year":2012,"publication_date":"2012-11-30","ids":{"openalex":"https://openalex.org/W2017746032","doi":"https://doi.org/10.4199/c00067ed1v01y201210isp037","mag":"2017746032"},"language":"en","primary_location":{"id":"doi:10.4199/c00067ed1v01y201210isp037","doi":"https://doi.org/10.4199/c00067ed1v01y201210isp037","is_oa":false,"landing_page_url":"https://doi.org/10.4199/c00067ed1v01y201210isp037","pdf_url":null,"source":{"id":"https://openalex.org/S4210171109","display_name":"Colloquium Series on Integrated Systems Physiology From Molecule to Function","issn_l":"2154-560X","issn":["2154-560X","2154-5626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310322570","host_organization_name":"Morgan & Claypool Publishers","host_organization_lineage":["https://openalex.org/P4310322570"],"host_organization_lineage_names":["Morgan & Claypool Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloquium Series on Integrated Systems Physiology: From Molecule to Function","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039523466","display_name":"D. Keith Payne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Keith Payne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022804104","display_name":"Adam Wellikoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Wellikoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.18210749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"5","first_page":"1","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.358599990606308,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.358599990606308,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.1875,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.1306000053882599,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-structure","display_name":"alveolar structure","score":0.843999981880188},{"id":"https://openalex.org/keywords/pulmonary-gas-exchange","display_name":"pulmonary gas exchange","score":0.6990000009536743},{"id":"https://openalex.org/keywords/ventilation-perfusion-matching","display_name":"ventilation-perfusion matching","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pulmonary-capillary-bed","display_name":"pulmonary capillary bed","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.6050000190734863},{"id":"https://openalex.org/keywords/inhaled-pollutants","display_name":"inhaled pollutants","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5750113129615784},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.45332518219947815},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.4301179051399231},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3662540912628174},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36140790581703186},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3410208225250244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24964138865470886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17929592728614807},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17064398527145386},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12926045060157776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11749497056007385},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.1049235463142395},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10425341129302979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4199/c00067ed1v01y201210isp037","doi":"https://doi.org/10.4199/c00067ed1v01y201210isp037","is_oa":false,"landing_page_url":"https://doi.org/10.4199/c00067ed1v01y201210isp037","pdf_url":null,"source":{"id":"https://openalex.org/S4210171109","display_name":"Colloquium Series on Integrated Systems Physiology From Molecule to Function","issn_l":"2154-560X","issn":["2154-560X","2154-5626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310322570","host_organization_name":"Morgan & Claypool Publishers","host_organization_lineage":["https://openalex.org/P4310322570"],"host_organization_lineage_names":["Morgan & Claypool Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloquium Series on Integrated Systems Physiology: From Molecule to Function","raw_type":"journal-article"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-028223316","doi":null,"is_oa":false,"landing_page_url":"http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=515760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W79238399","https://openalex.org/W79768903","https://openalex.org/W177236013","https://openalex.org/W236234631","https://openalex.org/W264657038","https://openalex.org/W308060944","https://openalex.org/W654375453","https://openalex.org/W1494180975","https://openalex.org/W1507074915","https://openalex.org/W1526607012","https://openalex.org/W1533328066","https://openalex.org/W1544599851","https://openalex.org/W1559205691","https://openalex.org/W1568500358","https://openalex.org/W1662007645","https://openalex.org/W1845975704","https://openalex.org/W1861641969","https://openalex.org/W1926884067","https://openalex.org/W1943200863","https://openalex.org/W1950581903","https://openalex.org/W1957734831","https://openalex.org/W1963966810","https://openalex.org/W1969921713","https://openalex.org/W1974911818","https://openalex.org/W1975308804","https://openalex.org/W1983491933","https://openalex.org/W1987025848","https://openalex.org/W1987878023","https://openalex.org/W1988742153","https://openalex.org/W1990258307","https://openalex.org/W1990588249","https://openalex.org/W1994168320","https://openalex.org/W1996840601","https://openalex.org/W1998402312","https://openalex.org/W1998975199","https://openalex.org/W2003976042","https://openalex.org/W2005481213","https://openalex.org/W2006963172","https://openalex.org/W2007058645","https://openalex.org/W2008145382","https://openalex.org/W2012244701","https://openalex.org/W2013038150","https://openalex.org/W2013889679","https://openalex.org/W2014100892","https://openalex.org/W2015620348","https://openalex.org/W2022306839","https://openalex.org/W2032576572","https://openalex.org/W2034073109","https://openalex.org/W2036967608","https://openalex.org/W2037144883","https://openalex.org/W2037394705","https://openalex.org/W2041986290","https://openalex.org/W2045908024","https://openalex.org/W2046156412","https://openalex.org/W2051185987","https://openalex.org/W2052747544","https://openalex.org/W2058225299","https://openalex.org/W2058926972","https://openalex.org/W2060126259","https://openalex.org/W2061588012","https://openalex.org/W2064121457","https://openalex.org/W2067538132","https://openalex.org/W2067560247","https://openalex.org/W2074058951","https://openalex.org/W2080967898","https://openalex.org/W2086007602","https://openalex.org/W2088311074","https://openalex.org/W2089335976","https://openalex.org/W2097663027","https://openalex.org/W2098861154","https://openalex.org/W2099051314","https://openalex.org/W2099090035","https://openalex.org/W2100293996","https://openalex.org/W2100852869","https://openalex.org/W2102663974","https://openalex.org/W2103010344","https://openalex.org/W2104642638","https://openalex.org/W2104934425","https://openalex.org/W2109563104","https://openalex.org/W2111071070","https://openalex.org/W2118516780","https://openalex.org/W2118601874","https://openalex.org/W2120831204","https://openalex.org/W2124749786","https://openalex.org/W2126763289","https://openalex.org/W2131817432","https://openalex.org/W2132040583","https://openalex.org/W2137075665","https://openalex.org/W2137498246","https://openalex.org/W2137744809","https://openalex.org/W2138094019","https://openalex.org/W2143576416","https://openalex.org/W2144689930","https://openalex.org/W2154141105","https://openalex.org/W2156876763","https://openalex.org/W2160686569","https://openalex.org/W2162089683","https://openalex.org/W2164450314","https://openalex.org/W2167761305","https://openalex.org/W2169299504","https://openalex.org/W2169458189","https://openalex.org/W2182541906","https://openalex.org/W2182930588","https://openalex.org/W2275545763","https://openalex.org/W2315096416","https://openalex.org/W2331885588","https://openalex.org/W2339616473","https://openalex.org/W2401005822","https://openalex.org/W2403278336","https://openalex.org/W2407833734","https://openalex.org/W2413526025","https://openalex.org/W2415472234","https://openalex.org/W2423979791","https://openalex.org/W2435014391","https://openalex.org/W2486808169","https://openalex.org/W2736044217","https://openalex.org/W4210760982","https://openalex.org/W4232147078","https://openalex.org/W4241505084","https://openalex.org/W4255289348","https://openalex.org/W4313333737"],"related_works":["https://openalex.org/W2532403685","https://openalex.org/W6921518470","https://openalex.org/W2412802766","https://openalex.org/W4388165095","https://openalex.org/W2034255544","https://openalex.org/W2895407326","https://openalex.org/W2430787213","https://openalex.org/W3155190433","https://openalex.org/W4205626464","https://openalex.org/W2566439396"],"abstract_inverted_index":{"In":[0],"the":[1,5,10,43,54,71,75,89,94,97,100,105,112,125,136,146,167,170,181],"distal":[2],"regions":[3],"of":[4,9,24,57,96,102,111,129,133,151,169],"human":[6,171],"lung,":[7],"one":[8],"most":[11],"challenging":[12],"problems":[13],"facing":[14],"a":[15,79,130,149],"large":[16],"multicellular":[17],"organism":[18],"is":[19,161],"solved\u2014ensuring":[20],"an":[21],"adequate":[22],"supply":[23],"oxygen":[25,58],"for":[26,36],"aerobic":[27],"tissue":[28],"metabolism":[29],"while":[30],"removing":[31],"associated":[32,118],"waste":[33],"products.":[34],"Conduits":[35],"both":[37],"air":[38],"and":[39,51,59,66,99,115,127,154,159],"blood":[40,103],"converge":[41],"at":[42],"alveolar":[44,86,113,157],"level":[45],"to":[46,70,84,144,165,179],"match":[47],"ventilation":[48],"with":[49],"perfusion":[50],"thus":[52],"assure":[53],"free":[55],"diffusion":[56],"carbon":[60],"dioxide.":[61],"Despite":[62],"their":[63,67],"thin":[64],"walls":[65],"intimate":[68],"relationship":[69],"pulmonary":[72,106],"capillary":[73,119],"bed,":[74],"alveolus":[76],"must":[77],"present":[78],"barrier":[80],"function":[81,160],"robust":[82],"enough":[83],"resist":[85],"flooding":[87],"from":[88,148],"hydrostatic":[90],"pressures":[91],"generated":[92],"by":[93],"weight":[95],"lungs":[98],"volume":[101],"in":[104,124,173],"circuit.":[107],"The":[108],"strategic":[109],"position":[110],"region":[114],"its":[116,122,174],"vast":[117],"network":[120],"ensure":[121],"importance":[123],"synthesis":[126],"degradation":[128],"wide":[131],"range":[132],"molecules.":[134],"Finally,":[135],"alveoli":[137],"have":[138],"evolved":[139],"important":[140],"immune":[141],"functions":[142],"vital":[143],"protecting":[145],"host":[147],"variety":[150],"inhaled":[152],"pollutants":[153],"microorganisms.":[155],"Understanding":[156],"structure":[158],"essential":[162],"not":[163],"only":[164],"appreciate":[166],"elegance":[168],"lung":[172,186],"pristine":[175],"state":[176],"but":[177],"also":[178],"understand":[180],"perturbations":[182],"that":[183],"underlay":[184],"many":[185],"diseases.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}