{"id":"https://openalex.org/W2017735077","doi":"https://doi.org/10.4103/0975-1483.83765","title":"Formulation and Evaluation of Solid Lipid Nanoparticles of Ramipril","display_name":"Formulation and Evaluation of Solid Lipid Nanoparticles of Ramipril","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2017735077","doi":"https://doi.org/10.4103/0975-1483.83765","mag":"2017735077","pmid":"https://pubmed.ncbi.nlm.nih.gov/21897661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159275"},"language":"en","primary_location":{"id":"doi:10.4103/0975-1483.83765","doi":"https://doi.org/10.4103/0975-1483.83765","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0975-1483.83765","pdf_url":null,"source":{"id":"https://openalex.org/S172241011","display_name":"Journal of Young Pharmacists","issn_l":"0975-1483","issn":["0975-1483","0975-1505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Young Pharmacists","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159275","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P. Ekambaram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Ekambaram","raw_affiliation_strings":["Department of Pharmaceutics, Madurai Medical College, Madurai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Madurai Medical College, Madurai, Tamilnadu, India","institution_ids":["https://openalex.org/I15664174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029061739","display_name":"A. Abdul Hasan Sathali","orcid":"https://orcid.org/0000-0002-7991-9292","observed_orcids":["https://orcid.org/0000-0002-7991-9292"]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Abdul Hasan Sathali","raw_affiliation_strings":["Department ofPharmaceutics, Madurai Medical College, Madurai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofPharmaceutics, Madurai Medical College, Madurai, Tamilnadu, India","institution_ids":["https://openalex.org/I15664174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I15664174"],"apc_list":null,"apc_paid":null,"fwci":2.1418,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.84718935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"3","issue":"3","first_page":"216","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.3005000054836273,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ramipril","display_name":"ramipril","score":1.0},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8159999847412109},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8059999942779541},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.5149999856948853},{"id":"https://openalex.org/keywords/glycerol-monostearate","display_name":"glyceryl monostearate","score":0.8669999837875366},{"id":"https://openalex.org/keywords/glycerol-monooleate","display_name":"glycerol monooleate","score":1.0},{"id":"https://openalex.org/keywords/surfactants","display_name":"surfactants","score":0.871999979019165},{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tween-80","display_name":"Tween 80","score":0.8510000109672546},{"id":"https://openalex.org/keywords/span-20","display_name":"Span 20","score":0.9879999756813049},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9229999780654907},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.9620000123977661},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7620000243186951},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.738163948059082},{"id":"https://openalex.org/C2779888176","wikidata":"https://www.wikidata.org/wiki/Q412666","display_name":"Ramipril","level":3,"score":0.7333475947380066},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.6111215949058533},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5660313963890076},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5387018918991089},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4968893826007843},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.49577149748802185},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.4911899268627167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48990458250045776},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42988908290863037},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4241783618927002},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32534825801849365},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.218834787607193},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18014386296272278},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.17434808611869812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1360158920288086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06773737072944641},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/0975-1483.83765","doi":"https://doi.org/10.4103/0975-1483.83765","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0975-1483.83765","pdf_url":null,"source":{"id":"https://openalex.org/S172241011","display_name":"Journal of Young Pharmacists","issn_l":"0975-1483","issn":["0975-1483","0975-1505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Young Pharmacists","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2174209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3159275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Young Pharm","raw_type":"Text"},{"id":"pmid:21897661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21897661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of young pharmacists : JYP","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2174209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1579046626","https://openalex.org/W1977755432","https://openalex.org/W1978477577","https://openalex.org/W2044903986","https://openalex.org/W2045260358","https://openalex.org/W2056700668","https://openalex.org/W2101070296","https://openalex.org/W2117576781","https://openalex.org/W2128863256"],"related_works":["https://openalex.org/W2994070904","https://openalex.org/W4403146564","https://openalex.org/W3152256148","https://openalex.org/W3080907297","https://openalex.org/W2981707537","https://openalex.org/W2026537351","https://openalex.org/W4293394088","https://openalex.org/W3182273681","https://openalex.org/W2275714481","https://openalex.org/W2790125956"],"abstract_inverted_index":{"Solid":[0],"lipid":[1,92],"nanoparticles":[2,93],"are":[3,96],"typically":[4],"spherical":[5],"with":[6,106,146,168],"an":[7,17,36,75],"average":[8],"diameter":[9],"between":[10],"1":[11],"and":[12,29,32,50,70,84,103,112,138,158,171],"1000":[13],"nm.":[14],"It":[15],"is":[16,35,48,52],"alternative":[18],"carrier":[19],"system":[20],"to":[21,85,165],"tradition":[22],"colloidal":[23],"carriers,":[24],"such":[25,65],"as,":[26,66],"emulsions,":[27],"liposomes,":[28],"polymeric":[30],"micro":[31],"nanoparticles.":[33],"Ramipril":[34],"antihypertensive":[37],"agent":[38],"used":[39],"in":[40],"the":[41,56,81,87],"treatment":[42],"of":[43,89,94],"hypertension.":[44],"Its":[45],"oral":[46],"bioavailability":[47,88],"28%":[49],"it":[51],"rapidly":[53],"excreted":[54],"through":[55],"renal":[57],"route.":[58],"This":[59],"drug":[60,124,127,153],"has":[61],"many":[62],"side":[63,82],"effects":[64,83],"postural":[67],"hypotension,":[68],"hyperkalemia,":[69],"angioedema,":[71],"when":[72],"given":[73],"as":[74,149,163],"immediate":[76],"dosage":[77],"form.":[78],"To":[79],"overcome":[80],"increase":[86],"ramipril,":[90],"solid":[91],"ramipril":[95],"prepared":[97,116],"by":[98],"using":[99],"lipids":[100],"(glyceryl":[101],"monostearate":[102],"glyceryl":[104,143],"monooleate)":[105],"stabilizers":[107],"(tween":[108],"80,":[109],"poloxamer":[110],"188,":[111],"span":[113,147],"20).":[114],"The":[115],"formulations":[117,167],"have":[118],"been":[119],"evaluated":[120],"for":[121],"entrapment":[122],"efficiency,":[123],"content,":[125],"in-vitro":[126],"release,":[128,154],"particle":[129,156,160],"size":[130,161],"analysis,":[131],"scanning":[132],"electron":[133],"spectroscopy,":[134],"Fourier":[135],"transform-infrared":[136],"studies,":[137],"stability.":[139],"A":[140],"formulation":[141],"containing":[142],"monooleate,":[144],"stabilized":[145],"20":[148],"surfactant":[150],"showed":[151],"prolonged":[152],"smaller":[155],"size,":[157],"narrow":[159],"distribution,":[162],"compared":[164],"other":[166],"different":[169],"surfactants":[170],"lipids.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
