{"id":"https://openalex.org/W2017734995","doi":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","title":"THE ASSAY OF MILK\u2010EJECTING ACTIVITY IN THE LACTATING RAT","display_name":"THE ASSAY OF MILK\u2010EJECTING ACTIVITY IN THE LACTATING RAT","publication_year":1967,"publication_date":"1967-11-01","ids":{"openalex":"https://openalex.org/W2017734995","doi":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","mag":"2017734995","pmid":"https://pubmed.ncbi.nlm.nih.gov/4295636","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1557341"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1967.tb00418.x","doi":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1967.tb00418.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1967.tb00418.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064320535","display_name":"G. W. Bisset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. W. BISSET","raw_affiliation_strings":["National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049898322","display_name":"Barbara J. Clark","orcid":"https://orcid.org/0000-0003-1558-1904","observed_orcids":["https://orcid.org/0000-0003-1558-1904"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"BARBARA J. CLARK","raw_affiliation_strings":["National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004687937","display_name":"Jaya Haldar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"JAYA HALDAR","raw_affiliation_strings":["Department of Pathology, McMaster University, Hamilton, Ontario, Canada","National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103417581","display_name":"M. C. Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. C. HARRIS","raw_affiliation_strings":["School of Pharmacy, Brunswick Square, London, W.C.1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Brunswick Square, London, W.C.1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109086539","display_name":"G. P. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. P. LEWIS","raw_affiliation_strings":["National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, Mill Hill, London, and CIBA Laboratories, Horsham, Sussex","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020485558","display_name":"M. ROCHA e SILVA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. ROCHA e SILVA","raw_affiliation_strings":["Faculty of Medicine, University of Sa\u0303o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.8209,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.98918919,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"31","issue":"3","first_page":"537","last_page":"549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.24560000002384186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5419999957084656},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.7160000205039978},{"id":"https://openalex.org/keywords/uterine-contraction","display_name":"uterine contraction","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5137661695480347},{"id":"https://openalex.org/C16057445","wikidata":"https://www.wikidata.org/wiki/Q44494","display_name":"Mill","level":2,"score":0.4788234531879425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34054023027420044},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.12742072343826294},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.12629640102386475},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11005502939224243}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1967.tb00418.x","doi":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1967.tb00418.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1557341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1557341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol Chemother","raw_type":"Text"},{"id":"pmid:4295636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4295636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1967.tb00418.x","doi":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1967.tb00418.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1967.tb00418.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017734995.pdf","grobid_xml":"https://content.openalex.org/works/W2017734995.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W145896463","https://openalex.org/W205799967","https://openalex.org/W288184330","https://openalex.org/W1083836483","https://openalex.org/W1966640898","https://openalex.org/W1977502110","https://openalex.org/W1999120460","https://openalex.org/W2002023695","https://openalex.org/W2002551447","https://openalex.org/W2004738472","https://openalex.org/W2005568769","https://openalex.org/W2041915536","https://openalex.org/W2048459707","https://openalex.org/W2050415068","https://openalex.org/W2056243570","https://openalex.org/W2064501568","https://openalex.org/W2073174570","https://openalex.org/W2077822062","https://openalex.org/W2078521807","https://openalex.org/W2085640965","https://openalex.org/W2091856029","https://openalex.org/W2095262823","https://openalex.org/W2116510010","https://openalex.org/W2284880109","https://openalex.org/W2409247516","https://openalex.org/W2476706593","https://openalex.org/W2495632431"],"related_works":["https://openalex.org/W2091856029","https://openalex.org/W3013933183","https://openalex.org/W2010257224","https://openalex.org/W2042824128","https://openalex.org/W2048459707","https://openalex.org/W1966640898","https://openalex.org/W2095326947","https://openalex.org/W1977502110","https://openalex.org/W7101048740","https://openalex.org/W2161170193"],"abstract_inverted_index":{"One":[0],"of":[1,24,37,45,76,84,102,142,153,165,168,189,198,214,223,227,269,278,316],"the":[2,12,25,28,35,43,46,49,60,64,77,81,92,136,151,154,157,174,221,228,258,267,276,279,285,302,310,314],"most":[3],"sensitive":[4,126],"methods":[5],"for":[6],"assaying":[7],"oxytocin":[8,199,270,307],"is":[9,262],"to":[10,73,80,194,255,265,306],"measure":[11],"increase":[13,149,183],"in":[14,48,59,118,150,156,173,184,200,271,298,301,304],"milk-ejection":[15,50,299],"pressure":[16,127,132,300],"which":[17,119],"results":[18],"from":[19,34,135],"a":[20,54,95,103,114,170,181],"close":[21,162],"arterial":[22],"injection":[23,83],"hormone":[26],"into":[27,91],"lactating":[29,61,158,259,280],"mammary":[30],"gland.This":[31],"method":[32,117,188],"originates":[33],"work":[36,245,286],"Cross":[38],"&":[39,110,177,207,211,235,241,292],"Harris":[40],"(1952)":[41],"on":[42],"role":[44],"neurohypophysis":[47,78],"reflex.In":[51],"this":[52,244,274],"work,":[53],"teat":[55],"duct":[56,138],"was":[57,66,89,98,133],"cannulated":[58,137],"rabbit":[62,159],"and":[63,94,106,129,186,204,290],"cannula":[65,93],"partly":[67],"filled":[68],"with":[69,139,220,257],"citrate":[70],"solution.In":[71],"response":[72,305],"electrical":[74],"stimulation":[75],"or":[79],"intravenous":[82,311],"posterior":[85],"pituitary":[86],"extract,":[87],"milk":[88,130],"ejected":[90],"volume":[96,120],"change":[97],"registered":[99],"by":[100,124,160,309],"means":[101],"piston":[104],"recorder":[105],"kymograph.Van":[107],"Dyke,":[108],"Adamsons":[109],"Engels":[111],"(1955)":[112],"developed":[113],"quantitative":[115],"assay":[116,155,190],"recorders":[121],"were":[122],"replaced":[123],"highly":[125],"transducers":[128],"ejection":[131],"recorded":[134,296],"minimal":[140],"displacement":[141],"fluid.Fitzpatrick":[143],"(1961)":[144],"achieved":[145],"an":[146,246],"almost":[147],"40-fold":[148],"sensitivity":[152,185,249,317],"giving":[161],"arterial,":[163],"instead":[164],"intravenous,":[166],"injections":[167],"oxytocin.Using":[169],"similar":[171],"technique":[172],"guinea-pig,":[175],"Tindal":[176],"Yokoyama":[178],"(1962)":[179],"obtained":[180],"further":[182],"their":[187],"has":[191,282],"been":[192,218,253,283],"used":[193],"estimate":[195],"small":[196],"amounts":[197],"blood":[201,272],"during":[202],"suckling":[203],"parturition":[205],"(Folley":[206],"Knaggs,":[208],"1965a;":[209],"Fitzpatrick":[210],"Walmsley,":[212],"1965).Many":[213],"our":[215],"investigations":[216],"have":[217,252,295],"concerned":[219],"problem":[222],"demonstrating":[224],"independent":[225],"release":[226],"neurohypophysial":[229],"hormones":[230],"(Haldar,":[231],"1966;":[232],"Bisset,":[233,239],"Hilton":[234],"Poisner,":[236],"1967;":[237],"Beleslin,":[238],"Haldar":[240],"Polak,":[242],"1967).In":[243],"even":[247],"greater":[248],"than":[250],"we":[251],"able":[254],"obtain":[256],"guinea-pig":[260],"preparation":[261],"often":[263],"required":[264],"exclude":[266],"presence":[268],"extracts.For":[273],"purpose":[275],"use":[277],"rat":[281,303],"investigated.Since":[284],"began,":[287],"Grosvenor":[288,293],"(1965)":[289],"DeNuccio":[291],"(1967)":[294],"increases":[297],"given":[308],"route,":[312],"but":[313],"limit":[315],"Permanent":[318],"addresses:":[319]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
