{"id":"https://openalex.org/W2017727620","doi":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","title":"Bronchial hyperresponsiveness and airway neutrophil accumulation induced by interleukin\u20108 and the effect of the thromboxane A2 antagonist S\u20101452 in guinea\u2010pigs","display_name":"Bronchial hyperresponsiveness and airway neutrophil accumulation induced by interleukin\u20108 and the effect of the thromboxane A2 antagonist S\u20101452 in guinea\u2010pigs","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2017727620","doi":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","mag":"2017727620","pmid":"https://pubmed.ncbi.nlm.nih.gov/7728625"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2222.1995.tb01002.x","doi":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110294829","display_name":"Qingyu Xiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Q. XIU","raw_affiliation_strings":["Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan","The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210104330"]},{"raw_affiliation_string":"The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113010038","display_name":"M Fujimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. FUJIMURA","raw_affiliation_strings":["The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034073288","display_name":"Masatoshi Nomura","orcid":"https://orcid.org/0000-0002-0725-3161","observed_orcids":["https://orcid.org/0000-0002-0725-3161"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. NOMURA","raw_affiliation_strings":["The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070358717","display_name":"Motoyasu Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. SAITO","raw_affiliation_strings":["The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110383147","display_name":"T Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. MATSUDA","raw_affiliation_strings":["The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008829844","display_name":"Nobuaki Akao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. AKAO","raw_affiliation_strings":["Department of Pharmacology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189267","display_name":"Kaoru Kondo","orcid":"https://orcid.org/0009-0008-7529-4791","observed_orcids":["https://orcid.org/0009-0008-7529-4791"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. KONDO","raw_affiliation_strings":["Department of Parasitology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005730268","display_name":"Kouji Matsushima","orcid":"https://orcid.org/0000-0003-1056-171X","observed_orcids":["https://orcid.org/0000-0003-1056-171X","https://orcid.org/0000-0002-6739-3289"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. MATSUSHIMA","raw_affiliation_strings":["Department of Pharmacology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Cancer Research Institute, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113010038"],"corresponding_institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":3.1877,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91502123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"25","issue":"1","first_page":"51","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9490000009536743},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thromboxane-receptor-antagonist","display_name":"thromboxane A2 receptor antagonist","score":0.8130000233650208},{"id":"https://openalex.org/keywords/s-1452","display_name":"S-1452","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5789999961853027},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.800000011920929},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7770000100135803},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8029180765151978},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.743522047996521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5863015055656433},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5440011620521545},{"id":"https://openalex.org/C2778074680","wikidata":"https://www.wikidata.org/wiki/Q2125439","display_name":"Cannula","level":2,"score":0.46193352341651917},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.4601912796497345},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.4571513831615448},{"id":"https://openalex.org/C2776238763","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Bronchial hyperresponsiveness","level":4,"score":0.4518647789955139},{"id":"https://openalex.org/C2777242621","wikidata":"https://www.wikidata.org/wiki/Q647917","display_name":"Leukotriene D4","level":4,"score":0.446353554725647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4428275525569916},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.439524382352829},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.43762916326522827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4300718605518341},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.42597854137420654},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3739435076713562},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3634231686592102},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.30234479904174805},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2849096953868866},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.28053033351898193},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.2657589316368103},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07609564065933228},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06615930795669556}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2222.1995.tb01002.x","doi":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.1995.tb01002.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},{"id":"pmid:7728625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7728625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318231","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W12531342","https://openalex.org/W41837633","https://openalex.org/W182121550","https://openalex.org/W1565707529","https://openalex.org/W1607098455","https://openalex.org/W1831017703","https://openalex.org/W1920283256","https://openalex.org/W1936491616","https://openalex.org/W1948079963","https://openalex.org/W1963821021","https://openalex.org/W1965778637","https://openalex.org/W1966866092","https://openalex.org/W1971664259","https://openalex.org/W1977322309","https://openalex.org/W2010349134","https://openalex.org/W2012241915","https://openalex.org/W2017659011","https://openalex.org/W2027085000","https://openalex.org/W2031229780","https://openalex.org/W2038778872","https://openalex.org/W2050901258","https://openalex.org/W2051936219","https://openalex.org/W2063153627","https://openalex.org/W2065719831","https://openalex.org/W2066380266","https://openalex.org/W2072947578","https://openalex.org/W2074149057","https://openalex.org/W2075896189","https://openalex.org/W2082200515","https://openalex.org/W2085592945","https://openalex.org/W2090214382","https://openalex.org/W2090229369","https://openalex.org/W2114518763","https://openalex.org/W2116313488","https://openalex.org/W2122794487","https://openalex.org/W2123884323","https://openalex.org/W2144909336","https://openalex.org/W2154945180","https://openalex.org/W2312870247","https://openalex.org/W2474631914","https://openalex.org/W4242669803"],"related_works":["https://openalex.org/W2418916524","https://openalex.org/W1973563224","https://openalex.org/W2153407374","https://openalex.org/W2171365457","https://openalex.org/W1979391869","https://openalex.org/W1967027989","https://openalex.org/W2472404433","https://openalex.org/W2049879838","https://openalex.org/W2165963744","https://openalex.org/W2048027981"],"abstract_inverted_index":{"Interleukin-8":[0],"(IL-8)":[1],"has":[2],"been":[3],"shown":[4],"to":[5,49,88,107],"be":[6],"a":[7,39,52,110,123,130,174],"chemotactic":[8],"factor":[9],"for":[10,54],"neutrophils,":[11,178],"T-lymphocytes":[12],"and":[13,66,72,97,134,143,190,199,231],"eosinophils,":[14,181],"but":[15,179],"it":[16],"is":[17],"unknown":[18],"whether":[19],"the":[20,26,30,60,76,217,220,244],"IL-8-induced":[21],"inflammatory":[22],"cell":[23],"accumulation":[24],"into":[25],"airways":[27],"can":[28],"cause":[29],"bronchial":[31,105],"hyperresponsiveness":[32],"(BHR)":[33],"characteristic":[34],"of":[35,41,85,91,120,132,137,177,203,219],"asthma.":[36],"IL-8":[37,101,138,170,204,238],"at":[38,75,129],"dose":[40,131],"0.5":[42,133,198],"or":[43,226],"5":[44,135,200],"micrograms/kg":[45,136],"was":[46,79,139,151],"administered":[47],"intranasally":[48],"guinea-pigs":[50],"twice":[51],"week":[53],"3":[55],"weeks.":[56],"One":[57],"day":[58],"after":[59],"last":[61],"administration,":[62],"animals":[63,161,195],"were":[64],"anesthetized":[65],"artificially":[67],"ventilated":[68],"through":[69],"tracheal":[70],"cannula":[71,77],"lateral":[73],"pressure":[74],"(Pao)":[78],"measured":[80],"as":[81],"an":[82],"overall":[83],"index":[84],"airway":[86],"responses":[87],"increasing":[89],"concentrations":[90],"inhaled":[92],"histamine":[93,108,121],"(25,":[94],"50,":[95],"100,":[96],"200":[98],"micrograms/ml).":[99,168],"The":[100,117,149,169],"treatment":[102,171],"significantly":[103,152,242],"enhanced":[104],"responsiveness":[106],"in":[109,126,159,182,194,209],"dose-dependent":[111],"manner":[112],"(ANOVA":[113,247],"P":[114,248],"<":[115,154,249],"0.01).":[116],"provocative":[118],"concentration":[119],"causing":[122],"100%":[124],"increase":[125],"Pao":[127],"(PC100)":[128],"68.1":[140],"(GSEM":[141,145],"1.12)":[142],"35.6":[144],"1.25)":[146],"micrograms/ml,":[147],"respectively.":[148],"latter":[150],"(P":[153],"0.01)":[155],"lower":[156],"than":[157],"that":[158],"control":[160],"treated":[162,196],"with":[163,197],"PBS":[164],"(93.3":[165],"[GSEM,":[166],"1.14]":[167],"also":[172],"induced":[173,239],"significant":[175],"influx":[176],"not":[180],"bronchoalveolar":[183],"lavage":[184],"(BAL)":[185],"fluid":[186],"(18.3":[187],"+/-":[188,192,207],"8.8":[189],"30.6":[191],"8.3%":[193],"micrograms/kg,":[201],"respectively,":[202],"vs":[205],"3.6":[206],"0.7%":[208],"phosphate":[210],"buffered":[211],"saline-(PBS)-treated":[212],"animals).":[213],"Furthermore,":[214],"we":[215],"examined":[216],"effect":[218],"thromboxane":[221],"receptor":[222],"antagonist":[223],"S-1452":[224,241],"(0.01":[225],"0.1":[227],"mg/kg,":[228],"i.p.":[229],"24":[230],"1":[232],"h":[233],"before":[234],"anesthesia)":[235],"on":[236],"this":[237],"BHR.":[240],"inhibited":[243],"BHR":[245],"dose-dependently":[246],"0.001).(ABSTRACT":[250],"TRUNCATED":[251],"AT":[252],"250":[253],"WORDS)":[254]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
