{"id":"https://openalex.org/W2017722874","doi":"https://doi.org/10.1002/jps.2600770614","title":"Bile Acid Binding and Hypocholesterolemic Activity of a New Anion Exchange Resin from 2-Methylimidazol and Epichlorohydrin","display_name":"Bile Acid Binding and Hypocholesterolemic Activity of a New Anion Exchange Resin from 2-Methylimidazol and Epichlorohydrin","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2017722874","doi":"https://doi.org/10.1002/jps.2600770614","mag":"2017722874","pmid":"https://pubmed.ncbi.nlm.nih.gov/3171935"},"language":"en","primary_location":{"id":"doi:10.1002/jps.2600770614","doi":"https://doi.org/10.1002/jps.2600770614","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600770614","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110029225","display_name":"Hideo Toda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1306287861","display_name":"Mitsubishi Group (Japan)","ror":"https://ror.org/0234cd281","country_code":"JP","type":"company","lineage":["https://openalex.org/I1306287861"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Toda","raw_affiliation_strings":["Central Research Laboratory, Mitsubishi Yuka Company, Ltd., Ibaraki, Japan","Central Research Laboratory Mitsubishi Yuka Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300\u201003, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory, Mitsubishi Yuka Company, Ltd., Ibaraki, Japan","institution_ids":[]},{"raw_affiliation_string":"Central Research Laboratory Mitsubishi Yuka Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300\u201003, Japan","institution_ids":["https://openalex.org/I1306287861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014005153","display_name":"Kunio Kihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1306287861","display_name":"Mitsubishi Group (Japan)","ror":"https://ror.org/0234cd281","country_code":"JP","type":"company","lineage":["https://openalex.org/I1306287861"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kunio Kihara","raw_affiliation_strings":["Central Research Laboratory Mitsubishi Yuka Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory Mitsubishi Yuka Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan","institution_ids":["https://openalex.org/I1306287861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023926574","display_name":"Munehiro Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168192097","display_name":"Mitsubishi Chemical (Japan)","ror":"https://ror.org/05d8avs16","country_code":"JP","type":"company","lineage":["https://openalex.org/I168192097"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Munehiro Hashimoto","raw_affiliation_strings":["Tsukuba Pharaceuticals Laboratory, Mitsubishi Chemical Industry Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Pharaceuticals Laboratory, Mitsubishi Chemical Industry Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan","institution_ids":["https://openalex.org/I168192097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061756662","display_name":"Susumu Mizogami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168192097","display_name":"Mitsubishi Chemical (Japan)","ror":"https://ror.org/05d8avs16","country_code":"JP","type":"company","lineage":["https://openalex.org/I168192097"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Mizogami","raw_affiliation_strings":["Tsukuba Pharaceuticals Laboratory, Mitsubishi Chemical Industry Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Pharaceuticals Laboratory, Mitsubishi Chemical Industry Company, Ltd., Chuo, Ami, Inashiki, Ibaraki, 300-03, Japan","institution_ids":["https://openalex.org/I168192097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014005153"],"corresponding_institution_ids":["https://openalex.org/I1306287861"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.3925,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.47901804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"77","issue":"6","first_page":"531","last_page":"533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14303","display_name":"Polymer Synthesis and Characterization","score":0.36059999465942383,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0934000015258789,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anion-exchange-resin","display_name":"anion exchange resin","score":0.878000020980835},{"id":"https://openalex.org/keywords/bile-acid-binding","display_name":"bile acid binding","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hypocholesterolemic-activity","display_name":"hypocholesterolemic activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epichlorohydrin","display_name":"epichlorohydrin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/plasma-cholesterol-reduction","display_name":"plasma cholesterol reduction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cholesterol-fed-rabbits","display_name":"cholesterol-fed rabbits","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.8747001886367798},{"id":"https://openalex.org/C2778925040","wikidata":"https://www.wikidata.org/wiki/Q423083","display_name":"Epichlorohydrin","level":2,"score":0.8326084613800049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7284814715385437},{"id":"https://openalex.org/C73523448","wikidata":"https://www.wikidata.org/wiki/Q1989369","display_name":"Ion-exchange resin","level":2,"score":0.7208703756332397},{"id":"https://openalex.org/C2911023556","wikidata":"https://www.wikidata.org/wiki/Q287415","display_name":"Sodium Cholate","level":2,"score":0.6733993291854858},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5828936100006104},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4856637716293335},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4750264286994934},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4223783016204834},{"id":"https://openalex.org/C117760992","wikidata":"https://www.wikidata.org/wiki/Q389137","display_name":"Ion exchange","level":3,"score":0.41305097937583923},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3469405174255371},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.32600152492523193},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.2560320794582367},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2165922224521637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1919666826725006},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002728","descriptor_name":"Chlorohydrins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004811","descriptor_name":"Epichlorohydrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004811","descriptor_name":"Epichlorohydrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007474","descriptor_name":"Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007475","descriptor_name":"Ion Exchange Resins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007475","descriptor_name":"Ion Exchange Resins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.2600770614","doi":"https://doi.org/10.1002/jps.2600770614","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600770614","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:3171935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3171935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1971561018","https://openalex.org/W1971783846","https://openalex.org/W2012952446","https://openalex.org/W2057420175","https://openalex.org/W2060657150","https://openalex.org/W2066604140","https://openalex.org/W2098442584","https://openalex.org/W2123616918","https://openalex.org/W2125750804","https://openalex.org/W2152981750","https://openalex.org/W2158437653","https://openalex.org/W2334622412","https://openalex.org/W2335440726","https://openalex.org/W2337307543"],"related_works":["https://openalex.org/W4252295077","https://openalex.org/W2010439863","https://openalex.org/W2337307543","https://openalex.org/W1967734139","https://openalex.org/W2605428259","https://openalex.org/W2334622412","https://openalex.org/W2098442584","https://openalex.org/W4231710645","https://openalex.org/W2466534182","https://openalex.org/W2323789542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}