{"id":"https://openalex.org/W2017717574","doi":"https://doi.org/10.1111/all.12166","title":"Role of plasmacytoid dendritic cell subsets in allergic asthma","display_name":"Role of plasmacytoid dendritic cell subsets in allergic asthma","publication_year":2013,"publication_date":"2013-05-11","ids":{"openalex":"https://openalex.org/W2017717574","doi":"https://doi.org/10.1111/all.12166","mag":"2017717574","pmid":"https://pubmed.ncbi.nlm.nih.gov/23662841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693732"},"language":"en","primary_location":{"id":"doi:10.1111/all.12166","doi":"https://doi.org/10.1111/all.12166","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12166","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12166","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12166","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008278385","display_name":"Hadi Maazi","orcid":"https://orcid.org/0000-0002-8979-3769","observed_orcids":["https://orcid.org/0000-0002-8979-3769"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Maazi","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033-9605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033-9605, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lam","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088904153","display_name":"Vincent C. Lombardi","orcid":"https://orcid.org/0000-0003-4474-8662","observed_orcids":["https://orcid.org/0000-0003-4474-8662"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Lombardi","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027660549","display_name":"Omid Akbari","orcid":"https://orcid.org/0000-0002-4359-9725","observed_orcids":["https://orcid.org/0000-0002-4359-9725","https://orcid.org/0000-0002-6853-9884"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"O. Akbari","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology Keck School of Medicine University of Southern California Los Angeles CA USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California, Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027660549"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":0.4403,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.40609592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"6","first_page":"695","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.15539999306201935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.10239999741315842,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7979999780654907},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9449999928474426},{"id":"https://openalex.org/keywords/retinaldehyde-dehydrogenase","display_name":"retinaldehyde dehydrogenase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.716938316822052},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6588000059127808},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.607547402381897},{"id":"https://openalex.org/C2776051438","wikidata":"https://www.wikidata.org/wiki/Q12045567","display_name":"Plasmacytoid dendritic cell","level":4,"score":0.5276293158531189},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.44828900694847107},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4342663586139679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4076090157032013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3819230794906616},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27193862199783325},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.17692938446998596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17277154326438904}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/all.12166","doi":"https://doi.org/10.1111/all.12166","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12166","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12166","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:23662841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23662841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3014756","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3693732","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3693732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Allergy","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/all.12166","doi":"https://doi.org/10.1111/all.12166","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12166","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12166","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7055940974","display_name":"Role of NKT cells in airway hyperreactivity & tolerance","funder_award_id":"R01AI066020","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017717574.pdf","grobid_xml":"https://content.openalex.org/works/W2017717574.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1497758343","https://openalex.org/W1502985829","https://openalex.org/W1595037199","https://openalex.org/W1661858862","https://openalex.org/W1855946711","https://openalex.org/W1967879964","https://openalex.org/W1975929837","https://openalex.org/W1976824666","https://openalex.org/W1977650430","https://openalex.org/W1984631044","https://openalex.org/W1987772726","https://openalex.org/W1991240417","https://openalex.org/W1992060275","https://openalex.org/W1992439632","https://openalex.org/W1996253790","https://openalex.org/W1996939314","https://openalex.org/W1997732724","https://openalex.org/W2000148776","https://openalex.org/W2005538857","https://openalex.org/W2007316487","https://openalex.org/W2009404162","https://openalex.org/W2012571305","https://openalex.org/W2012574191","https://openalex.org/W2015812428","https://openalex.org/W2016121277","https://openalex.org/W2018280156","https://openalex.org/W2018887114","https://openalex.org/W2025635725","https://openalex.org/W2029629696","https://openalex.org/W2035041510","https://openalex.org/W2039622942","https://openalex.org/W2041416134","https://openalex.org/W2045659086","https://openalex.org/W2053485564","https://openalex.org/W2054581136","https://openalex.org/W2056461632","https://openalex.org/W2059411759","https://openalex.org/W2063917748","https://openalex.org/W2064371482","https://openalex.org/W2065528190","https://openalex.org/W2066146382","https://openalex.org/W2067821750","https://openalex.org/W2069330688","https://openalex.org/W2071670416","https://openalex.org/W2072910092","https://openalex.org/W2073144071","https://openalex.org/W2073219633","https://openalex.org/W2084006363","https://openalex.org/W2088230924","https://openalex.org/W2090685407","https://openalex.org/W2092743770","https://openalex.org/W2100930818","https://openalex.org/W2104059085","https://openalex.org/W2104904748","https://openalex.org/W2113449254","https://openalex.org/W2114709782","https://openalex.org/W2115889659","https://openalex.org/W2119945903","https://openalex.org/W2122718122","https://openalex.org/W2123204370","https://openalex.org/W2123895022","https://openalex.org/W2129938799","https://openalex.org/W2131914577","https://openalex.org/W2133854193","https://openalex.org/W2134512036","https://openalex.org/W2135463092","https://openalex.org/W2146091784","https://openalex.org/W2147650681","https://openalex.org/W2151369808","https://openalex.org/W2155792963","https://openalex.org/W2156150500","https://openalex.org/W2157923883","https://openalex.org/W2158722408","https://openalex.org/W2159966160","https://openalex.org/W2167366928","https://openalex.org/W2167465779","https://openalex.org/W2169988783","https://openalex.org/W2172203436","https://openalex.org/W4236153851"],"related_works":["https://openalex.org/W4313386781","https://openalex.org/W2098862181","https://openalex.org/W2045659086","https://openalex.org/W2996581914","https://openalex.org/W2147650681","https://openalex.org/W2033762002","https://openalex.org/W4407694818","https://openalex.org/W2058595198","https://openalex.org/W130431336","https://openalex.org/W762340025"],"abstract_inverted_index":{"Plasmacytoid":[0],"dendritic":[1],"cells":[2,8,20,111],"(pDCs)":[3],"are":[4],"major":[5],"type-I":[6],"interferon-producing":[7],"that":[9],"play":[10],"important":[11],"roles":[12],"in":[13,91,150,161],"antiviral":[14],"immunity":[15],"and":[16,29,53,70,77,115],"tolerance":[17],"induction.":[18],"These":[19,96,122],"share":[21],"a":[22],"common":[23],"DC":[24],"progenitor":[25],"with":[26,156],"conventional":[27],"DCs,":[28],"Fms-like":[30],"tyrosine":[31],"kinase-3":[32],"ligand":[33],"is":[34],"essential":[35],"for":[36,131,135],"their":[37],"development.":[38],"Several":[39],"subsets":[40,58,125],"of":[41,59,107,118,126,138,153],"pDCs":[42,60,84,127],"have":[43,88],"been":[44],"identified":[45],"to":[46,87,101,158],"date":[47],"including":[48],"CCR9(+)":[49],",":[50,52,66,69],"CD9(+)":[51],"CD2(+)":[54],"pDCs.":[55],"Recently,":[56],"three":[57],"were":[61,85,99],"described,":[62],"namely":[63],"CD8\u03b1(-)":[64,82],"\u03b2(-)":[65,68,76,83],"CD8\u03b1(+)":[67,71,75,78],"\u03b2(+)":[72,79],"subsets.":[73],"Interestingly,":[74],"but":[80],"not":[81],"shown":[86,100],"tolerogenic":[89,97],"effects":[90,98],"experimentally":[92],"induced":[93],"allergic":[94,139,159,163],"asthma.":[95,164],"be":[102],"mediated":[103],"by":[104],"the":[105,116,136,147],"generation":[106],"FOXP3(+)":[108],"regulatory":[109],"T":[110],"through":[112],"retinoic":[113],"acid":[114],"induction":[117],"retinaldehyde":[119],"dehydrogenase":[120],"enzymes.":[121],"newly":[123],"described":[124],"show":[128],"high":[129],"potentials":[130],"novel":[132],"therapeutic":[133],"approaches":[134],"treatment":[137],"diseases.":[140],"In":[141],"this":[142],"review,":[143],"we":[144],"will":[145],"address":[146],"new":[148],"progress":[149],"our":[151],"understanding":[152],"pDC":[154],"biology":[155],"respect":[157],"disease,":[160],"particular":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
