{"id":"https://openalex.org/W2017716899","doi":"https://doi.org/10.1097/mcg.0b013e3182652096","title":"Role of the Gut Barrier in Acute Pancreatitis","display_name":"Role of the Gut Barrier in Acute Pancreatitis","publication_year":2012,"publication_date":"2012-09-06","ids":{"openalex":"https://openalex.org/W2017716899","doi":"https://doi.org/10.1097/mcg.0b013e3182652096","mag":"2017716899","pmid":"https://pubmed.ncbi.nlm.nih.gov/22955357"},"language":"en","primary_location":{"id":"doi:10.1097/mcg.0b013e3182652096","doi":"https://doi.org/10.1097/mcg.0b013e3182652096","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcg.0b013e3182652096","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085191511","display_name":"Gabriele Capurso","orcid":"https://orcid.org/0000-0002-0019-8753","observed_orcids":["https://orcid.org/0000-0002-0019-8753"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gabriele Capurso","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy. gabriele.capurso@uniroma1.it","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy. gabriele.capurso@uniroma1.it","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033621462","display_name":"Giulia Zerboni","orcid":"https://orcid.org/0000-0003-2983-727X","observed_orcids":["https://orcid.org/0000-0003-2983-727X"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Zerboni","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112414931","display_name":"Marianna Signoretti","orcid":"https://orcid.org/0000-0002-8576-782X","observed_orcids":["https://orcid.org/0000-0002-8576-782X"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marianna Signoretti","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033287955","display_name":"Roberto Valente","orcid":"https://orcid.org/0000-0002-6785-2326","observed_orcids":["https://orcid.org/0000-0002-6785-2326"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Valente","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009789603","display_name":"Serena Stigliano","orcid":"https://orcid.org/0000-0002-1225-8370","observed_orcids":["https://orcid.org/0000-0002-1225-8370"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Stigliano","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066695507","display_name":"Matteo Piciucchi","orcid":"https://orcid.org/0000-0002-9359-4789","observed_orcids":["https://orcid.org/0000-0002-9359-4789"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Piciucchi","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Sant'Andrea Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sant'Andrea Hospital","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112256412","display_name":"Gianfranco Delle Fave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianfranco Delle Fave","raw_affiliation_strings":["Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","Medical-surgical Sciences and Translational Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Medical-surgical Sciences and Translational Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085191511"],"corresponding_institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":8.6723,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.98084846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"46","issue":null,"first_page":"S46","last_page":"S51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.781000018119812},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/intravenous-antibiotics","display_name":"intravenous antibiotics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8930000066757202},{"id":"https://openalex.org/keywords/splanchnic-vasoconstriction","display_name":"splanchnic vasoconstriction","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9222724437713623},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.6128218770027161},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5944289565086365},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3351672291755676},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3227619528770447}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004750","descriptor_name":"Enteral Nutrition","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020896","descriptor_name":"Hypovolemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/mcg.0b013e3182652096","doi":"https://doi.org/10.1097/mcg.0b013e3182652096","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcg.0b013e3182652096","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},{"id":"pmid:22955357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22955357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/536957","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/536957","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/151817","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11768/151817","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1502372295","https://openalex.org/W1618156669","https://openalex.org/W1896125460","https://openalex.org/W1974226598","https://openalex.org/W1975415019","https://openalex.org/W1981258912","https://openalex.org/W1991752063","https://openalex.org/W2009566241","https://openalex.org/W2021218395","https://openalex.org/W2026936598","https://openalex.org/W2028091201","https://openalex.org/W2028276007","https://openalex.org/W2041607966","https://openalex.org/W2046920071","https://openalex.org/W2050522311","https://openalex.org/W2051726712","https://openalex.org/W2055259541","https://openalex.org/W2060077640","https://openalex.org/W2061141762","https://openalex.org/W2061401592","https://openalex.org/W2065605458","https://openalex.org/W2070922088","https://openalex.org/W2081527168","https://openalex.org/W2085803061","https://openalex.org/W2087270126","https://openalex.org/W2094130358","https://openalex.org/W2096085007","https://openalex.org/W2102503776","https://openalex.org/W2112230262","https://openalex.org/W2115176390","https://openalex.org/W2117989802","https://openalex.org/W2121288079","https://openalex.org/W2121388563","https://openalex.org/W2122196470","https://openalex.org/W2124877004","https://openalex.org/W2126413585","https://openalex.org/W2136196992","https://openalex.org/W2141060555","https://openalex.org/W2153551421","https://openalex.org/W2166847341","https://openalex.org/W2312188351","https://openalex.org/W2313373592"],"related_works":["https://openalex.org/W7098643708","https://openalex.org/W2312188351","https://openalex.org/W2424723409","https://openalex.org/W2049141980","https://openalex.org/W2394607856","https://openalex.org/W2369230708","https://openalex.org/W2076962973","https://openalex.org/W2351293726","https://openalex.org/W2134407884","https://openalex.org/W2905558468"],"abstract_inverted_index":{"The":[0,139],"small":[1,118],"intestine":[2],"is":[3,57,151],"one":[4,91],"of":[5,23,53,61,81,92,96,102,112,141,147,156,180],"the":[6,26,40,44,51,54,70,82,93,99,110,113,117,128,132,148,154,178,181],"distant":[7],"organs":[8],"that":[9],"become":[10],"damaged":[11],"during":[12],"severe":[13,47,103],"acute":[14,104],"pancreatitis,":[15],"due":[16,130],"to":[17,108,126,131,144,171,175],"microcirculation":[18],"disturbance":[19],"associated":[20,58],"with":[21,59],"loss":[22],"fluids":[24],"in":[25,69,98,116,163,166],"\"third":[27],"space,\"":[28],"hypovolemia,":[29],"splanchnic":[30],"vasoconstriction,":[31],"and":[32,63,65,79,85,135,153,165,188],"finally":[33],"an":[34],"ischemia-reperfusion":[35],"injury.":[36],"In":[37],"this":[38],"scenario,":[39],"gut":[41,114],"acts":[42],"as":[43,50],"starter":[45],"for":[46,77,86],"systemic":[48,87],"complications,":[49],"failure":[52],"intestinal":[55,71],"barrier":[56,115],"translocation":[60],"bacteria":[62],"inflammatory":[64,88],"toxic":[66],"products":[67],"produced":[68],"wall,":[72],"which":[73,158],"can":[74],"be":[75,107,172],"responsible":[76],"sepsis":[78],"infection":[80,146],"necrotic":[83],"pancreas":[84],"response.":[89],"Therefore,":[90],"main":[94],"goals":[95],"treatment":[97],"early":[100,136,167],"phases":[101],"pancreatitis":[105],"should":[106],"maintain":[109],"integrity":[111],"intestine.":[119],"These":[120],"strategies":[121],"include":[122],"appropriate":[123],"fluid":[124],"resuscitation":[125],"limit":[127],"damage":[129],"relative":[133],"hypovolemia":[134],"enteral":[137],"feeding.":[138],"role":[140,155],"intravenous":[142],"antibiotics":[143],"prevent":[145],"pancreatic":[149],"necrosis":[150],"controversial":[152],"probiotics,":[157],"seemed":[159],"a":[160],"promising":[161],"tool":[162],"vitro":[164],"clinical":[168,193],"trials,":[169],"needs":[170],"further":[173],"investigated":[174],"better":[176],"understand":[177],"effects":[179],"single":[182],"specific":[183],"strains":[184],"at":[185],"various":[186],"doses":[187],"timing":[189],"before":[190],"designing":[191],"new":[192],"trials.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}