{"id":"https://openalex.org/W2017711538","doi":"https://doi.org/10.1371/journal.pone.0049209","title":"Lipoteichoic Acid from Staphylococcus aureus Induces Lung Endothelial Cell Barrier Dysfunction: Role of Reactive Oxygen and Nitrogen Species","display_name":"Lipoteichoic Acid from Staphylococcus aureus Induces Lung Endothelial Cell Barrier Dysfunction: Role of Reactive Oxygen and Nitrogen Species","publication_year":2012,"publication_date":"2012-11-15","ids":{"openalex":"https://openalex.org/W2017711538","doi":"https://doi.org/10.1371/journal.pone.0049209","mag":"2017711538","pmid":"https://pubmed.ncbi.nlm.nih.gov/23166614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3499573"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0049209","doi":"https://doi.org/10.1371/journal.pone.0049209","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049209","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049209&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049209&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047374751","display_name":"Amy Barton Pai","orcid":"https://orcid.org/0000-0002-7131-5267","observed_orcids":["https://orcid.org/0000-0002-7131-5267"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy Barton Pai","raw_affiliation_strings":["Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA. amy.bartonpai@acphs.edu","Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA. amy.bartonpai@acphs.edu","institution_ids":["https://openalex.org/I365282"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012496689","display_name":"Heena V Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heena Patel","raw_affiliation_strings":["Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012241232","display_name":"Alexander J. Prokopienko","orcid":"https://orcid.org/0000-0002-8828-8365","observed_orcids":["https://orcid.org/0000-0002-8828-8365"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander J. Prokopienko","raw_affiliation_strings":["Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034604260","display_name":"Hiba Alsaffar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiba Alsaffar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038548210","display_name":"Nancy Gertzberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Gertzberg","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059335504","display_name":"Paul H. Neumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Neumann","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028206839","display_name":"Anjoli Punjabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjoli Punjabi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100866594","display_name":"Arnold Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Johnson","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047374751"],"corresponding_institution_ids":["https://openalex.org/I365282"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.7701,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.66522193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"11","first_page":"e49209","last_page":"e49209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoteichoic-acid","display_name":"lipoteichoic acid","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-barrier-dysfunction","display_name":"endothelial barrier dysfunction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pulmonary-microvascular-endothelial-cells","display_name":"pulmonary microvascular endothelial cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tlr2-signaling","display_name":"TLR2 signaling","score":0.7089999914169312},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.949999988079071},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.7580000162124634},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8199999928474426},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.996999979019165},{"id":"https://openalex.org/keywords/tiron","display_name":"Tiron","score":0.640999972820282},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.8529999852180481},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C6977687","wikidata":"https://www.wikidata.org/wiki/Q781350","display_name":"Lipoteichoic acid","level":4,"score":0.8236842155456543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.542222797870636},{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.45933452248573303},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39208176732063293},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3785071074962616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3462297320365906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26554107666015625},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.22369453310966492},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005070","descriptor_name":"Evans Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013682","descriptor_name":"Teichoic Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014013","descriptor_name":"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026361","descriptor_name":"Reactive Nitrogen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062905","descriptor_name":"Central Venous Catheters","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0049209","doi":"https://doi.org/10.1371/journal.pone.0049209","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049209","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049209&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2499543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3499573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23166614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23166614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3499573","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3499573/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.811.532","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.811.532","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/28/pone.0049209.PMC3499573.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:57ecddb1666f48febce17b481dc8e31e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57ecddb1666f48febce17b481dc8e31e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e49209 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0049209","doi":"https://doi.org/10.1371/journal.pone.0049209","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049209","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049209&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7428731032","display_name":null,"funder_award_id":"5R01HL05990112","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G813204199","display_name":"A mechanism for suppression of TNF induced endothelial dysfunction","funder_award_id":"R01HL059901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017711538.pdf","grobid_xml":"https://content.openalex.org/works/W2017711538.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1658843865","https://openalex.org/W1963751749","https://openalex.org/W1964718835","https://openalex.org/W1986500032","https://openalex.org/W1988293824","https://openalex.org/W1992345427","https://openalex.org/W1998504259","https://openalex.org/W2001342722","https://openalex.org/W2003483747","https://openalex.org/W2005159276","https://openalex.org/W2016862474","https://openalex.org/W2039582913","https://openalex.org/W2040450824","https://openalex.org/W2043823247","https://openalex.org/W2044003874","https://openalex.org/W2050949616","https://openalex.org/W2069445637","https://openalex.org/W2071510909","https://openalex.org/W2076956984","https://openalex.org/W2077306969","https://openalex.org/W2077332810","https://openalex.org/W2085167010","https://openalex.org/W2094407725","https://openalex.org/W2099576969","https://openalex.org/W2102124140","https://openalex.org/W2102578076","https://openalex.org/W2102910971","https://openalex.org/W2103783390","https://openalex.org/W2103822465","https://openalex.org/W2107220679","https://openalex.org/W2107914421","https://openalex.org/W2109086417","https://openalex.org/W2113213861","https://openalex.org/W2115904774","https://openalex.org/W2124145819","https://openalex.org/W2125760444","https://openalex.org/W2127079941","https://openalex.org/W2127415556","https://openalex.org/W2130946949","https://openalex.org/W2135050229","https://openalex.org/W2143926371","https://openalex.org/W2153750479","https://openalex.org/W2157339124","https://openalex.org/W2161877684","https://openalex.org/W2162775093","https://openalex.org/W2169322130","https://openalex.org/W2169499363","https://openalex.org/W2337560579"],"related_works":["https://openalex.org/W1505972426","https://openalex.org/W2317481953","https://openalex.org/W1925967280","https://openalex.org/W2149184032","https://openalex.org/W2088355317","https://openalex.org/W2319113744","https://openalex.org/W2169499363","https://openalex.org/W2907793057","https://openalex.org/W1890955362","https://openalex.org/W2094407725"],"abstract_inverted_index":{"Tunneled":[0],"central":[1],"venous":[2],"catheters":[3],"(TCVCs)":[4],"are":[5,17,92],"used":[6],"for":[7],"dialysis":[8],"access":[9],"in":[10,76,152,234],"82%":[11],"of":[12,29,56,79,89,101,109,115,127,134,185,223,228],"new":[13],"hemodialysis":[14],"patients":[15],"and":[16,32,91,124,137,161,178,199,225],"rapidly":[18],"colonized":[19],"with":[20,142,213],"Gram-positive":[21,44],"organism":[22],"(e.g.":[23],"Staphylococcus":[24,72],"aureus)":[25],"biofilm,":[26],"a":[27,38,138],"source":[28],"recurrent":[30],"infections":[31],"chronic":[33],"inflammation.":[34],"Lipoteichoic":[35],"acid":[36],"(LTA),":[37],"cell":[39],"wall":[40],"ribitol":[41],"polymer":[42],"from":[43,71,87],"organisms,":[45],"mediates":[46,230],"inflammation":[47],"through":[48],"the":[49,67,77,106,113,116,125,132,145,171,186,190,195,221,226],"Toll-like":[50],"receptor":[51],"2":[52],"(TLR2).":[53],"The":[54,99,174,217],"effect":[55],"LTA":[57,70,143],"on":[58,176],"lung":[59],"endothelial":[60,82,162],"permeability":[61,78,100,177],"is":[62],"not":[63],"known.":[64],"We":[65],"tested":[66],"hypothesis":[68],"that":[69,85,220],"aureus":[73],"induces":[74],"alterations":[75],"pulmonary":[80],"microvessel":[81],"monolayers":[83],"(PMEM)":[84],"result":[86],"activation":[88,114,167,206,222],"TLR2":[90,117,146,224],"mediated":[93],"by":[94,105,121,131,170,183,211],"reactive":[95],"oxygen/nitrogen":[96],"species":[97],"(RONS).":[98],"PMEM":[102],"was":[103,119,129],"assessed":[104,120],"clearance":[107],"rate":[108],"Evans":[110],"blue-labeled":[111],"albumin,":[112],"pathway":[118],"Western":[122],"blot,":[123],"generation":[126,227],"RONS":[128,159,179],"measured":[130,169],"fluorescence":[133],"oxidized":[135],"dihydroethidium":[136],"dichlorofluorescein":[139],"derivative.":[140],"Treatment":[141],"or":[144,194,209],"agonist":[147],"Pam((3))CSK((4))":[148],"induced":[149],"significant":[150],"increases":[151],"albumin":[153],"permeability,":[154],"I\u03baB\u03b1":[155],"phosphorylation,":[156],"IRAK1":[157],"degradation,":[158],"generation,":[160],"nitric":[163],"oxide":[164],"synthase":[165],"(eNOS)":[166],"(as":[168],"p-eNOS(ser1177):p-eNOS(thr495)":[172],"ratio).":[173],"effects":[175,201],"were":[180,207],"effectively":[181],"prevented":[182,210],"co-administration":[184],"superoxide":[187],"scavenger":[188,192],"Tiron,":[189],"peroxynitrite":[191],"Urate,":[193],"eNOS":[196,205],"inhibitor":[197],"L-NAME":[198],"these":[200],"as":[202,204],"well":[203],"reduced":[208],"pretreatment":[212],"an":[214],"IRAK1/4":[215],"inhibitor.":[216],"results":[218],"indicate":[219],"ROS/RNS":[229],"LTA-induced":[231],"barrier":[232],"dysfunction":[233],"PMEM.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}