{"id":"https://openalex.org/W2017710096","doi":"https://doi.org/10.1073/pnas.1424637112","title":"cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection","display_name":"cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection","publication_year":2015,"publication_date":"2015-03-23","ids":{"openalex":"https://openalex.org/W2017710096","doi":"https://doi.org/10.1073/pnas.1424637112","mag":"2017710096","pmid":"https://pubmed.ncbi.nlm.nih.gov/25831530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4394261"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1424637112","doi":"https://doi.org/10.1073/pnas.1424637112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1424637112","pdf_url":"https://www.pnas.org/content/pnas/112/14/E1773.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/112/14/E1773.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089050724","display_name":"Megan H. Orzalli","orcid":"https://orcid.org/0000-0003-2177-1587","observed_orcids":["https://orcid.org/0000-0003-2177-1587"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan H. Orzalli","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","aDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068750174","display_name":"Nicole M. Broekema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Broekema","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052953896","display_name":"Benjamin A. Diner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin A. Diner","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 05844; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 05844; and","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062883688","display_name":"Dustin C. Hancks","orcid":"https://orcid.org/0000-0003-2720-2545","observed_orcids":["https://orcid.org/0000-0003-2720-2545"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin C. Hancks","raw_affiliation_strings":["Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","cDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"cDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040884279","display_name":"Nels C. Elde","orcid":"https://orcid.org/0000-0002-0426-1377","observed_orcids":["https://orcid.org/0000-0002-0426-1377"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nels C. Elde","raw_affiliation_strings":["Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","cDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"cDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047437797","display_name":"Ileana M. Cristea","orcid":"https://orcid.org/0000-0002-6533-2458","observed_orcids":["https://orcid.org/0000-0002-6533-2458"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ileana M. Cristea","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 05844; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 05844; and","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067933844","display_name":"David M. Knipe","orcid":"https://orcid.org/0000-0003-1554-6236","observed_orcids":["https://orcid.org/0000-0003-1554-6236"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Knipe","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.4855,"has_fulltext":true,"cited_by_count":275,"citation_normalized_percentile":{"value":0.99179696,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"112","issue":"14","first_page":"E1773","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ifi16","display_name":"IFI16","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cgas","display_name":"cGAS","score":1.0},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9509999752044678},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.5730000138282776},{"id":"https://openalex.org/keywords/viral-dna-sensing","display_name":"viral DNA sensing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/interferon-production","display_name":"interferon production","score":0.7070000171661377},{"id":"https://openalex.org/keywords/human-foreskin-fibroblasts","display_name":"human foreskin fibroblasts","score":0.8550000190734863},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/plasmid-dna","display_name":"plasmid DNA","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7619910836219788},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7011706233024597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6673543453216553},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6547614932060242},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5982683897018433},{"id":"https://openalex.org/C2779758228","wikidata":"https://www.wikidata.org/wiki/Q858790","display_name":"DNA virus","level":4,"score":0.5402138233184814},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5324462652206421},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5164544582366943},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.49708035588264465},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46221843361854553},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44603070616722107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3101828098297119},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21575278043746948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19033870100975037},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10387051105499268}],"mesh":[{"descriptor_ui":"D000099235","descriptor_name":"Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1424637112","doi":"https://doi.org/10.1073/pnas.1424637112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1424637112","pdf_url":"https://www.pnas.org/content/pnas/112/14/E1773.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3572180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4394261","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4394261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4394261","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:25831530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25831530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1424637112","doi":"https://doi.org/10.1073/pnas.1424637112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1424637112","pdf_url":"https://www.pnas.org/content/pnas/112/14/E1773.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G408252270","display_name":"Nuclear Sensing of Herpesviral DNA","funder_award_id":"R01AI106934","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4173086168","display_name":"Evolutionary potential of a model poxvirus","funder_award_id":"R00GM090042","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5296644119","display_name":"Proteomic Tools to Uncover the Role of Chromatin Remodeling in HIV-1 Infection","funder_award_id":"DP1DA026192","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5759438088","display_name":"Host Factors Required for Dengue and Yellow Fever Virus Amplification","funder_award_id":"R33AI102187","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5966746460","display_name":null,"funder_award_id":"14PRE18890044","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6087156556","display_name":"Mechanisms mediating immune response upon sensing of nuclear viral DNA","funder_award_id":"R01GM114141","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6320401451","display_name":null,"funder_award_id":"AI106934","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7432508447","display_name":"Epigenetic Regulation of HSV Infection of Oral Cells","funder_award_id":"R56DE023909","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7458711160","display_name":"Host Factors Required for Dengue and Yellow Fever Virus Amplification","funder_award_id":"R21AI102187","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7709449173","display_name":"Nuclear Sensing of Herpesviral DNA","funder_award_id":"R56AI106934","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000862973","display_name":"Training in Pediatric Gastroenterology, Hepatology, and Nutrition","funder_award_id":"T32DK007477","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868151","display_name":"Molecular Basis of Viral Infectivity","funder_award_id":"T32AI007245","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017710096.pdf","grobid_xml":"https://content.openalex.org/works/W2017710096.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W32423614","https://openalex.org/W1606562486","https://openalex.org/W1656209509","https://openalex.org/W1934619019","https://openalex.org/W1966202930","https://openalex.org/W1980923315","https://openalex.org/W1983487014","https://openalex.org/W1987333937","https://openalex.org/W2011678998","https://openalex.org/W2016131266","https://openalex.org/W2016771009","https://openalex.org/W2032898598","https://openalex.org/W2033448230","https://openalex.org/W2034291831","https://openalex.org/W2039390702","https://openalex.org/W2043215173","https://openalex.org/W2058277625","https://openalex.org/W2067409659","https://openalex.org/W2083093678","https://openalex.org/W2085192138","https://openalex.org/W2093578280","https://openalex.org/W2094249034","https://openalex.org/W2097895173","https://openalex.org/W2099060358","https://openalex.org/W2099610218","https://openalex.org/W2105121872","https://openalex.org/W2108827097","https://openalex.org/W2109735258","https://openalex.org/W2112331675","https://openalex.org/W2113117857","https://openalex.org/W2117827556","https://openalex.org/W2124651203","https://openalex.org/W2125957866","https://openalex.org/W2130576390","https://openalex.org/W2131617804","https://openalex.org/W2132093817","https://openalex.org/W2142756909","https://openalex.org/W2146546101","https://openalex.org/W2152041138","https://openalex.org/W2154171253","https://openalex.org/W2155463997","https://openalex.org/W2160776120","https://openalex.org/W2163362670"],"related_works":["https://openalex.org/W2553462502","https://openalex.org/W2163362670","https://openalex.org/W7154089612","https://openalex.org/W7097246373","https://openalex.org/W2797880468","https://openalex.org/W2588219496","https://openalex.org/W2130418469","https://openalex.org/W2095668059","https://openalex.org/W2753046080","https://openalex.org/W2174655399"],"abstract_inverted_index":{"Interferon":[0],"\u03b3-inducible":[1],"protein":[2],"16":[3],"(IFI16)":[4],"and":[5,24,103,110,122,141,153],"cGMP-AMP":[6,89],"synthase":[7],"(cGAS)":[8],"have":[9],"both":[10,40,70],"been":[11,33],"proposed":[12],"to":[13,124,148],"detect":[14],"herpesviral":[15,151],"DNA":[16,37,121,152],"directly":[17,132],"in":[18,52,78,90,99,108,144],"herpes":[19],"simplex":[20],"virus":[21],"(HSV)-infected":[22],"cells":[23],"initiate":[25,154],"interferon":[26],"regulatory":[27],"factor-3":[28],"signaling,":[29],"but":[30,93],"it":[31,130],"has":[32],"unclear":[34],"how":[35],"two":[36],"sensors":[38],"could":[39],"be":[41],"required":[42,72],"for":[43,73],"this":[44],"response.":[45],"We":[46,81],"therefore":[47],"investigated":[48],"their":[49],"relative":[50],"roles":[51],"human":[53,101],"foreskin":[54],"fibroblasts":[55,102],"(HFFs)":[56],"infected":[57,79,91],"with":[58,62,106,119,129,133],"HSV":[59],"or":[60],"transfected":[61],"plasmid":[63],"DNA.":[64,135],"siRNA":[65],"depletion":[66],"studies":[67],"showed":[68],"that":[69,83,139],"are":[71],"the":[74,112],"production":[75,87],"of":[76,88,114],"IFN":[77],"HFFs.":[80],"found":[82],"cGAS":[84,95,142],"shows":[85],"low":[86],"cells,":[92],"instead":[94],"is":[96,117],"partially":[97],"nuclear":[98,150],"normal":[100],"keratinocytes,":[104],"interacts":[105],"IFI16":[107,116,140],"fibroblasts,":[109],"promotes":[111],"stability":[113],"IFI16.":[115],"associated":[118],"viral":[120,125,134],"targets":[123],"genome":[126],"complexes,":[127],"consistent":[128],"interacting":[131],"Our":[136],"results":[137],"demonstrate":[138],"cooperate":[143],"a":[145],"novel":[146],"way":[147],"sense":[149],"innate":[155],"signaling.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
