{"id":"https://openalex.org/W2017700443","doi":"https://doi.org/10.1080/15287398409530572","title":"Dog pulmonary macrophage metabolism of free and particle\u2010associated [14C]benzo[a]pyrene","display_name":"Dog pulmonary macrophage metabolism of free and particle\u2010associated [14C]benzo[a]pyrene","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2017700443","doi":"https://doi.org/10.1080/15287398409530572","mag":"2017700443","pmid":"https://pubmed.ncbi.nlm.nih.gov/6209409"},"language":"en","primary_location":{"id":"doi:10.1080/15287398409530572","doi":"https://doi.org/10.1080/15287398409530572","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398409530572","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112735139","display_name":"James A. Bond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A. Bond","raw_affiliation_strings":["Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, P.O. Box 5890, Albuquerque, New Mexico, 87185","Inhalation Toxicology Research Institute , P.O. Box 5890, Albuquerque, New Mexico, 87185","Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, P.O. Box 5890, Albuquerque, New Mexico, 87185","institution_ids":[]},{"raw_affiliation_string":"Inhalation Toxicology Research Institute , P.O. Box 5890, Albuquerque, New Mexico, 87185","institution_ids":[]},{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075308780","display_name":"Michelle M. Butler","orcid":"https://orcid.org/0009-0003-2850-4841","observed_orcids":["https://orcid.org/0009-0003-2850-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle M. Butler","raw_affiliation_strings":["Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","Inhalation Toxicology Research Institute , Albuquerque, New Mexico","Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Inhalation Toxicology Research Institute , Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113673614","display_name":"Michele A. Medinsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele A. Medinsky","raw_affiliation_strings":["Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","Inhalation Toxicology Research Institute , Albuquerque, New Mexico","Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Inhalation Toxicology Research Institute , Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054165993","display_name":"Bruce A. Muggenburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce A. Muggenburg","raw_affiliation_strings":["Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","Inhalation Toxicology Research Institute , Albuquerque, New Mexico","Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Inhalation Toxicology Research Institute , Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108566137","display_name":"Roger O. McClellan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger O. McClellan","raw_affiliation_strings":["Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","Inhalation Toxicology Research Institute , Albuquerque, New Mexico","Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico; Inhalation Toxicology Research Institute, Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Inhalation Toxicology Research Institute , Albuquerque, New Mexico","institution_ids":[]},{"raw_affiliation_string":"Lovelace Biomedical and Environmental Research Institute , Albuquerque, New Mexico","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4778,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.58889783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"2-3","first_page":"181","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.953000009059906},{"id":"https://openalex.org/keywords/lung-macrophages","display_name":"lung macrophages","score":0.9950000047683716},{"id":"https://openalex.org/keywords/diesel-exhaust-particles","display_name":"diesel exhaust particles","score":0.9139999747276306},{"id":"https://openalex.org/keywords/benzo-a-pyrene-metabolism","display_name":"benzo[a]pyrene metabolism","score":0.8889999985694885},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.6380000114440918},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.7153165936470032},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.678709089756012},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.6637560129165649},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6608286499977112},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5995123982429504},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5468699932098389},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.47088488936424255},{"id":"https://openalex.org/C2779229383","wikidata":"https://www.wikidata.org/wiki/Q1501961","display_name":"Benzopyrene","level":4,"score":0.4105875790119171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3864545226097107},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33932673931121826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18752017617225647},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10455942153930664}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001335","descriptor_name":"Vehicle Emissions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287398409530572","doi":"https://doi.org/10.1080/15287398409530572","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398409530572","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},{"id":"pmid:6209409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6209409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1981100796","https://openalex.org/W1983041030","https://openalex.org/W1986283478","https://openalex.org/W1994790728","https://openalex.org/W1995101219","https://openalex.org/W2005669107","https://openalex.org/W2010485748","https://openalex.org/W2011268345","https://openalex.org/W2017214690","https://openalex.org/W2034608809","https://openalex.org/W2048237477","https://openalex.org/W2053533624","https://openalex.org/W2083788224","https://openalex.org/W2115995672","https://openalex.org/W2138783147","https://openalex.org/W2154755905","https://openalex.org/W2161886439","https://openalex.org/W2220860702","https://openalex.org/W2323441341","https://openalex.org/W2413386282","https://openalex.org/W4251834878"],"related_works":["https://openalex.org/W2005669107","https://openalex.org/W2034608809","https://openalex.org/W1967984073","https://openalex.org/W2053145744","https://openalex.org/W2025206772","https://openalex.org/W2017214690","https://openalex.org/W2131077509","https://openalex.org/W2049784132","https://openalex.org/W2032974606","https://openalex.org/W2066615079"],"abstract_inverted_index":{"Pulmonary":[0],"macrophages":[1],"(PM)":[2],"are":[3,17,213],"involved":[4],"in":[5,58,112,140,155,169,197,211,233],"the":[6,13,34,92,95,114,137,144,152,171,225,234],"clearance":[7],"of":[8,19,28,36,56,87,109,157,161,177,215,237],"inhaled":[9,240],"particulate":[10,242],"matter":[11],"from":[12,39,63,143],"lung.":[14],"PM":[15,37,60,88,188,220],"also":[16],"capable":[18,214],"metabolizing":[20,221],"xenobiotics":[21],"such":[22],"as":[23],"benzo[a]pyrene":[24],"(BaP).":[25],"The":[26,205],"objective":[27],"this":[29,52],"investigation":[30],"was":[31],"to":[32,41,50,82,130],"measure":[33],"ability":[35],"isolated":[38,62],"dogs":[40,66],"metabolize":[42],"BaP":[43,57,162,165,178],"coated":[44,201],"onto":[45],"diesel":[46,75,203],"exhaust":[47],"particles":[48,209],"and":[49,67,94,119,134,149,164,173,223],"compare":[51],"metabolism":[53,227],"with":[54,69,89,125,194],"that":[55,208,224],"solution.":[59],"were":[61,97,136,151,167,183,189],"male":[64],"beagle":[65],"incubated":[68,190],"1":[70],"microM":[71],"[14C]BaP":[72,101,110,196,200],"(solution":[73],"or":[74,199],"particle":[76],"coated)":[77],"for":[78,100,128,191],"select":[79],"times":[80],"up":[81,129],"48":[83,131],"h.":[84,132],"After":[85],"incubation":[86,126],"[14C]BaP,":[90],"both":[91,113,170],"cells":[93,120,172],"media":[96,115],"individually":[98],"analyzed":[99],"metabolites":[102,111,139,154,179],"by":[103,219],"high-performance":[104],"liquid":[105],"chromatography.":[106],"Total":[107,175],"quantities":[108,160,176],"(125":[116],"pmol/10(6)":[117,122,181],"cells)":[118,123,182],"(45":[121],"increased":[124],"time":[127],"BaP-9,10-diol":[133],"BaP-7,8-diol":[135,148],"major":[138,153],"organic":[141,238],"extracts":[142,156],"culture":[145],"media,":[146],"whereas":[147],"BaP-4,5-diol":[150],"cells.":[158],"Small":[159],"phenols":[163],"quinones":[166],"detected":[168],"media.":[174],"(20-30":[180],"not":[184],"significantly":[185],"different":[186],"when":[187],"24":[192],"h":[193],"either":[195],"solution":[198],"on":[202,241],"particles.":[204],"data":[206],"suggest":[207],"retained":[210],"lungs":[212],"being":[216],"acted":[217],"upon":[218],"enzymes":[222],"ensuing":[226],"may":[228],"play":[229],"an":[230],"important":[231],"role":[232],"metabolic":[235],"fate":[236],"material":[239],"matter.":[243]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}