{"id":"https://openalex.org/W2017693089","doi":"https://doi.org/10.3892/mmr.2012.1148","title":"Effect of fractionated irradiation on the expression of multidrug resistance genes in the CNE1 human nasopharyngeal carcinoma cell line","display_name":"Effect of fractionated irradiation on the expression of multidrug resistance genes in the CNE1 human nasopharyngeal carcinoma cell line","publication_year":2012,"publication_date":"2012-10-24","ids":{"openalex":"https://openalex.org/W2017693089","doi":"https://doi.org/10.3892/mmr.2012.1148","mag":"2017693089","pmid":"https://pubmed.ncbi.nlm.nih.gov/23128850"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2012.1148","doi":"https://doi.org/10.3892/mmr.2012.1148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.1148","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2012.1148/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2012.1148/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015595184","display_name":"Xuening Ji","orcid":"https://orcid.org/0000-0002-0732-8274","observed_orcids":["https://orcid.org/0000-0002-0732-8274"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XUE-NING JI","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, PR China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744930","display_name":"Fang Yang","orcid":"https://orcid.org/0000-0001-5644-5859","observed_orcids":["https://orcid.org/0000-0001-5644-5859"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FANG YANG","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029677788","display_name":"Xiaomei Sui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAO-MEI SUI","raw_affiliation_strings":["Department\u00a0of\u00a0Oncology, The Affiliated Hospital of Weifang Medical College, Weifang 261000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\u00a0of\u00a0Oncology, The Affiliated Hospital of Weifang Medical College, Weifang 261000, P.R. China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087320051","display_name":"Fuguang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FU-GUANG WANG","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084878164","display_name":"Ri-guang Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RI-GUANG GE","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056507821","display_name":"Xiulian Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIU-LIAN QUAN","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101642117","display_name":"Tong Zhao","orcid":"https://orcid.org/0000-0002-5394-2750","observed_orcids":["https://orcid.org/0000-0002-5394-2750"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TONG ZHAO","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"middle","author":{"id":null,"display_name":"BIN WEN GAO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"BIN WEN GAO","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033777521","display_name":"Ruoyu Wang","orcid":"https://orcid.org/0000-0002-3644-1284","observed_orcids":["https://orcid.org/0000-0002-3644-1284"]},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210145090","display_name":"Affiliated Zhongshan Hospital of Dalian University","ror":"https://ror.org/041ts2d40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145090"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RUO-YU WANG","raw_affiliation_strings":["Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhongshan Hospital, Dalian University, Dalian 116001, P.R. China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I4210145090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.327,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.60619885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"187","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fractionated-irradiation","display_name":"fractionated irradiation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/abcb1-gene","display_name":"MDR1 gene","score":0.8820000290870667},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cne1-cell-line","display_name":"CNE1 cell line","score":0.8289999961853027},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.6140000224113464},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.855223536491394},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6216065883636475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6003862619400024},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5497716069221497},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5490354895591736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5436474680900574},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.530914843082428},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5099915266036987},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.48419860005378723},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.4517469108104706},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43048354983329773},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42936980724334717},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4261504113674164},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42609792947769165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41204768419265747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3545391261577606},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.34803706407546997},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3189426064491272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21782216429710388},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1378307342529297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11610683798789978},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.06550332903862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06450453400611877}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011827","descriptor_name":"Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/mmr.2012.1148","doi":"https://doi.org/10.3892/mmr.2012.1148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.1148","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2012.1148/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:23128850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23128850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2012.1148","doi":"https://doi.org/10.3892/mmr.2012.1148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.1148","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2012.1148/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017693089.pdf","grobid_xml":"https://content.openalex.org/works/W2017693089.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1487423556","https://openalex.org/W1508258043","https://openalex.org/W1561005445","https://openalex.org/W1768841065","https://openalex.org/W1833499979","https://openalex.org/W1892519879","https://openalex.org/W1965577726","https://openalex.org/W1969749544","https://openalex.org/W1977301755","https://openalex.org/W1977395292","https://openalex.org/W1993307199","https://openalex.org/W2000334113","https://openalex.org/W2001402386","https://openalex.org/W2010076809","https://openalex.org/W2012724626","https://openalex.org/W2012784844","https://openalex.org/W2026106791","https://openalex.org/W2027629548","https://openalex.org/W2036490660","https://openalex.org/W2052457592","https://openalex.org/W2055148524","https://openalex.org/W2059703040","https://openalex.org/W2064836425","https://openalex.org/W2082452679","https://openalex.org/W2089052243","https://openalex.org/W2089459111","https://openalex.org/W2094393185","https://openalex.org/W2094666098","https://openalex.org/W2095907536","https://openalex.org/W2098715950","https://openalex.org/W2129603859","https://openalex.org/W2131173181","https://openalex.org/W2136851956","https://openalex.org/W2141779177","https://openalex.org/W2145844073","https://openalex.org/W2146514809","https://openalex.org/W2148649447","https://openalex.org/W2149352478","https://openalex.org/W2149662547","https://openalex.org/W2151534844","https://openalex.org/W2153739832","https://openalex.org/W2161884292","https://openalex.org/W2163891110","https://openalex.org/W2175131107","https://openalex.org/W2177347832","https://openalex.org/W2317007366","https://openalex.org/W2416761518","https://openalex.org/W6628992229","https://openalex.org/W6671031491"],"related_works":["https://openalex.org/W2363071884","https://openalex.org/W2351994166","https://openalex.org/W2356054458","https://openalex.org/W2367867624","https://openalex.org/W2349936435","https://openalex.org/W2349894461","https://openalex.org/W2591194730","https://openalex.org/W2604430234","https://openalex.org/W1714815311","https://openalex.org/W3030517204"],"abstract_inverted_index":{"Nasopharyngeal":[0],"carcinoma":[1],"(NPC)":[2],"often":[3],"develops":[4],"drug":[5,277],"resistance":[6,15,56],"following":[7,114,147,226,266],"radiotherapy.":[8],"The":[9,62,85,217],"molecular":[10],"basis":[11],"of":[12,27,33,65,91,94,108,122,187,213,219,234,251,275],"radiotherapy-related":[13],"multidrug":[14],"(MDR)":[16],"remains":[17],"unclear.":[18],"In":[19],"the":[20,25,31,34,38,104,106,120,132,200,230,248,252,273],"present":[21,97,253],"study,":[22],"we":[23],"investigated":[24],"effect":[26],"fractionated":[28,53,115],"irradiation":[29,154,197,227],"on":[30,155,202],"expression":[32,63,79,93,107,121,146,170,208],"MDR-1":[35,66],"gene":[36,83],"and":[37,67,73,128,138,151,158,168,175,205,240,259],"MDR-associated":[39],"protein":[40],"P-glycoprotein":[41],"(P-gp)":[42],"in":[43,98,263,272],"CNE1":[44,48,100,220,264],"human":[45],"NPC":[46],"cells.":[47,101],"cells":[49,221,265],"were":[50,69,96,237,243,270],"treated":[51],"with":[52,103,131,136,149,161,179,183,194,199,211,229,247],"X-rays.":[54],"Drug":[55],"was":[57,80,111,125,171,189,209,224],"determined":[58],"by":[59,71,82,134,177,192],"MTT":[60],"assay.":[61],"levels":[64,90],"P-gp":[68,207,260],"analyzed":[70,81],"RT-PCR":[72],"western":[74],"blot":[75],"analysis,":[76],"respectively.":[77,141],"Differential":[78],"chips.":[84],"results":[86],"revealed":[87],"that":[88,212,257],"low":[89],"mRNA":[92,110,124,215],"MDR1":[95,109,123,145,188,214,258],"non-irradiated":[99],"Compared":[102],"control,":[105,133],"gradually":[112],"increased":[113,126,172],"irradiation.":[116,267],"On":[117,164],"day":[118,162],"21,":[119,166],"1.59-":[127],"2.19-fold,":[129],"compared":[130,160,182,198,228,246],"treatment":[135,148,178,193],"10":[137,150,184],"20":[139,152,180],"Gy,":[140],"We":[142],"observed":[143],"decreased":[144],"Gy":[153,181,196],"days":[156,165,203],"28":[157,167],"35,":[159,169],"21.":[163],"1.37-,":[173],"1.40-":[174],"1.15-fold":[176],"Gy.":[185],"Expression":[186],"significantly":[190,238,244],"upregulated":[191,239,262],"50":[195],"control":[201],"78":[204],"106.":[206],"consistent":[210],"expression.":[216],"sensitivity":[218],"to":[222],"cisplatin":[223],"reduced":[225],"control.":[231,249],"A":[232],"total":[233],"26":[235],"genes":[236,242,269],"8":[241],"downregulated":[245],"Results":[250],"study":[254],"have":[255],"shown":[256],"are":[261],"Multiple":[268],"involved":[271],"mechanism":[274],"radiation-induced":[276],"resistance.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
