{"id":"https://openalex.org/W2017682182","doi":"https://doi.org/10.1053/jhep.2000.20239","title":"Tumor Necrosis Factor \u03b1 Prevents Tumor Necrosis Factor Receptor\u2014Mediated Mouse Hepatocyte Apoptosis, But Not Fas\u2013Mediated Apoptosis: Role of Nuclear Factor\u2013\u03baB","display_name":"Tumor Necrosis Factor \u03b1 Prevents Tumor Necrosis Factor Receptor\u2014Mediated Mouse Hepatocyte Apoptosis, But Not Fas\u2013Mediated Apoptosis: Role of Nuclear Factor\u2013\u03baB","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2017682182","doi":"https://doi.org/10.1053/jhep.2000.20239","mag":"2017682182","pmid":"https://pubmed.ncbi.nlm.nih.gov/11093734"},"language":"en","primary_location":{"id":"doi:10.1053/jhep.2000.20239","doi":"https://doi.org/10.1053/jhep.2000.20239","is_oa":true,"landing_page_url":"https://doi.org/10.1053/jhep.2000.20239","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2000.20239","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2000.20239","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079953843","display_name":"Masahito Nagaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahito Nagaki","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takafumi Naiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Naiki","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015535660","display_name":"David A. Brenner","orcid":"https://orcid.org/0000-0003-2573-525X","observed_orcids":["https://orcid.org/0000-0003-2573-525X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Brenner","raw_affiliation_strings":["Departments of Medicine, Biochemistry and Biophysics, and Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry and Biophysics, and Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089562604","display_name":"Yosuke Osawa","orcid":"https://orcid.org/0000-0003-3581-1009","observed_orcids":["https://orcid.org/0000-0003-3581-1009"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Osawa","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005261733","display_name":"Motoaki Imose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoaki Imose","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005778977","display_name":"Hideki Hayashi","orcid":"https://orcid.org/0000-0003-4585-6542","observed_orcids":["https://orcid.org/0000-0003-4585-6542"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Hayashi","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111570078","display_name":"Yoshiko Banno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiko Banno","raw_affiliation_strings":["Department of Biochemistry, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081933161","display_name":"Shigeru Nakashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Nakashima","raw_affiliation_strings":["Department of Biochemistry, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041284607","display_name":"Hisataka Moriwaki","orcid":"https://orcid.org/0000-0002-3798-4432","observed_orcids":["https://orcid.org/0000-0002-3798-4432"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hisataka Moriwaki","raw_affiliation_strings":["First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041284607"],"corresponding_institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.3935,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.79210643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"32","issue":"6","first_page":"1272","last_page":"1279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor","display_name":"TNF receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8560000061988831},{"id":"https://openalex.org/keywords/d-galactosamine-hepatotoxicity","display_name":"D-galactosamine hepatotoxicity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ikappab","display_name":"I\u03baB","score":0.8069999814033508},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/apoptosis-signaling-pathway","display_name":"apoptosis signaling","score":0.5189999938011169},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8003811836242676},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7071341872215271},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.6060843467712402},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.531863808631897},{"id":"https://openalex.org/C70905583","wikidata":"https://www.wikidata.org/wiki/Q3648608","display_name":"CD30","level":3,"score":0.52921062707901},{"id":"https://openalex.org/C118776929","wikidata":"https://www.wikidata.org/wiki/Q424381","display_name":"Tumor necrosis factors","level":3,"score":0.49360477924346924},{"id":"https://openalex.org/C54500882","wikidata":"https://www.wikidata.org/wiki/Q14914431","display_name":"Lymphotoxin beta receptor","level":4,"score":0.4902816116809845},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.4791761636734009},{"id":"https://openalex.org/C56483683","wikidata":"https://www.wikidata.org/wiki/Q7876087","display_name":"UVB-induced apoptosis","level":5,"score":0.4419924020767212},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4203639626502991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33618271350860596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2709087133407593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26263993978500366},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2523038387298584},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.24687397480010986},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.2260446846485138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20895686745643616},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06810423731803894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056587815284729004}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005688","descriptor_name":"Galactosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/jhep.2000.20239","doi":"https://doi.org/10.1053/jhep.2000.20239","is_oa":true,"landing_page_url":"https://doi.org/10.1053/jhep.2000.20239","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2000.20239","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:11093734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11093734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1053/jhep.2000.20239","doi":"https://doi.org/10.1053/jhep.2000.20239","is_oa":true,"landing_page_url":"https://doi.org/10.1053/jhep.2000.20239","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2000.20239","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017682182.pdf","grobid_xml":"https://content.openalex.org/works/W2017682182.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W384075993","https://openalex.org/W1210864738","https://openalex.org/W1492606093","https://openalex.org/W1558416075","https://openalex.org/W1658228410","https://openalex.org/W1888783223","https://openalex.org/W1965714370","https://openalex.org/W1981691673","https://openalex.org/W1982062664","https://openalex.org/W1983398917","https://openalex.org/W1993243592","https://openalex.org/W2002067726","https://openalex.org/W2002503549","https://openalex.org/W2011829290","https://openalex.org/W2033834764","https://openalex.org/W2035280748","https://openalex.org/W2046278309","https://openalex.org/W2065257477","https://openalex.org/W2067086178","https://openalex.org/W2067534266","https://openalex.org/W2073013917","https://openalex.org/W2082575834","https://openalex.org/W2091695331","https://openalex.org/W2110029891","https://openalex.org/W2118428501","https://openalex.org/W2135344687","https://openalex.org/W2151892297","https://openalex.org/W2185702474","https://openalex.org/W4313333867"],"related_works":["https://openalex.org/W2046278309","https://openalex.org/W2002141470","https://openalex.org/W2890896385","https://openalex.org/W1980147218","https://openalex.org/W1977565165","https://openalex.org/W2264654848","https://openalex.org/W2046188137","https://openalex.org/W2011555456","https://openalex.org/W967329409","https://openalex.org/W113795160"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor":[2],"alpha":[3],"(TNF-alpha)":[4],"binding":[5],"to":[6,71,106],"the":[7,16,39,91,108,150,157],"TNF":[8],"receptor":[9],"(TNFR)":[10],"initiates":[11],"apoptosis":[12,24,45,162],"and":[13,134,142],"simultaneously":[14],"activates":[15],"transcription":[17],"factor,":[18],"nuclear":[19],"factor-kappaB":[20],"(NF-kappaB),":[21],"which":[22,35],"suppresses":[23],"by":[25,149,164,172],"an":[26],"unknown":[27],"mechanism.":[28],"Pretreatment":[29],"with":[30,83,119,124,127],"TNF-alpha":[31,59,65,78,95,101,120],"or":[32],"interleukin-1beta":[33],"(IL-1beta),":[34],"activated":[36],"NF-kappaB":[37,75,153],"in":[38,46,74,98,116],"liver,":[40],"dramatically":[41],"prevented":[42],"TNF-alpha-induced":[43],"liver-cell":[44],"D-galactosamine":[47],"(GalN)-sensitized":[48],"mice,":[49],"but":[50,170],"not":[51,104,171],"anti-Fas":[52],"antibody-induced":[53],"hepatotoxicity.":[54],"This":[55],"protective":[56],"effect":[57,93],"of":[58,89,94,110,152,160,168],"continued":[60],"for":[61],"5":[62],"hours":[63],"after":[64,77],"administration,":[66],"a":[67,86,144],"time":[68],"course":[69],"similar":[70],"that":[72,132,143],"found":[73,105],"activation":[76,109,151],"administration.":[79],"In":[80],"mice":[81,117,125],"treated":[82,118,126],"adenoviruses":[84],"expressing":[85],"mutant":[87],"form":[88],"IkappaB,":[90],"antiapoptotic":[92],"was":[96,103,114],"inhibited":[97,115],"part.":[99],"Prior":[100],"administration":[102],"block":[107],"caspase-8,":[111,169],"although":[112],"caspase-3":[113],"plus":[121],"GalN/TNF-alpha":[122],"compared":[123],"GalN/TNF-alpha.":[128],"These":[129],"results":[130],"indicate":[131],"TNFR":[133],"Fas":[135],"independently":[136],"regulate":[137],"murine":[138],"apoptotic":[139],"liver":[140],"failure,":[141],"rapid":[145],"defense":[146],"mechanism":[147],"induced":[148],"blocks":[154],"death-signaling":[155],"at":[156],"initiation":[158],"stage":[159],"hepatic":[161],"mediated":[163],"TNFR,":[165],"probably":[166],"downstream":[167],"Fas.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}