{"id":"https://openalex.org/W2017680929","doi":"https://doi.org/10.1042/bc20080025","title":"Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles","display_name":"Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles","publication_year":2008,"publication_date":"2008-09-18","ids":{"openalex":"https://openalex.org/W2017680929","doi":"https://doi.org/10.1042/bc20080025","mag":"2017680929","pmid":"https://pubmed.ncbi.nlm.nih.gov/18422484"},"language":"en","primary_location":{"id":"doi:10.1042/bc20080025","doi":"https://doi.org/10.1042/bc20080025","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bc20080025","pdf_url":null,"source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011195396","display_name":"Sandrine Alais","orcid":"https://orcid.org/0000-0001-9588-5435","observed_orcids":["https://orcid.org/0000-0001-9588-5435"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Alais","raw_affiliation_strings":["LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011880812","display_name":"Sabrina Simoes","orcid":"https://orcid.org/0000-0002-9976-2501","observed_orcids":["https://orcid.org/0000-0002-9976-2501"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sabrina Simoes","raw_affiliation_strings":["Institut Curie, CNRS-UMR144 Structure et Compartiments Membranaires, 26 rue d'Ulm, 75248 Paris cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, CNRS-UMR144 Structure et Compartiments Membranaires, 26 rue d'Ulm, 75248 Paris cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210161403","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048986753","display_name":"Dominique Baas","orcid":"https://orcid.org/0000-0001-7970-717X","observed_orcids":["https://orcid.org/0000-0001-7970-717X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Baas","raw_affiliation_strings":["LBMC, UMR5161 CNRS-UCBL, Ecole Normale Supe\u0301rieure de Lyon 69364 Lyon cedex 07, France","Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","LBMC, UMR5161 CNRS-UCBL, Ecole Normale Sup\u00e9rieure de Lyon 69364 Lyon cedex 07, France","Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBMC, UMR5161 CNRS-UCBL, Ecole Normale Supe\u0301rieure de Lyon 69364 Lyon cedex 07, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775"]},{"raw_affiliation_string":"Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]},{"raw_affiliation_string":"LBMC, UMR5161 CNRS-UCBL, Ecole Normale Sup\u00e9rieure de Lyon 69364 Lyon cedex 07, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244795","display_name":"Sylvain Lehmann","orcid":"https://orcid.org/0000-0001-6117-562X","observed_orcids":["https://orcid.org/0000-0001-6117-562X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Lehmann","raw_affiliation_strings":["Institut de Ge\u0301ne\u0301tique Humaine (IGH), CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France","Institut de G\u00e9n\u00e9tique Humaine (IGH), CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Ge\u0301ne\u0301tique Humaine (IGH), CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine (IGH), CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069469830","display_name":"Gra\u00e7a Raposo","orcid":"https://orcid.org/0000-0001-9590-1298","observed_orcids":["https://orcid.org/0000-0001-9590-1298"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gra\u00e7a Raposo","raw_affiliation_strings":["Institut Curie, CNRS-UMR144 Structure et Compartiments Membranaires, 26 rue d'Ulm, 75248 Paris cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, CNRS-UMR144 Structure et Compartiments Membranaires, 26 rue d'Ulm, 75248 Paris cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210161403","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111711547","display_name":"Jean Luc Darlix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Luc Darlix","raw_affiliation_strings":["LaboRe\u0301tro INSERM U758, Unite\u0301 de Virologie Humaine, Ecole Normale Supe\u0301rieure de Lyon, 69364 Lyon Cedex 07, France","Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaboRe\u0301tro INSERM U758, Unite\u0301 de Virologie Humaine, Ecole Normale Supe\u0301rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]},{"raw_affiliation_string":"LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065925426","display_name":"Pascal Leblanc","orcid":"https://orcid.org/0000-0003-3214-5880","observed_orcids":["https://orcid.org/0000-0003-3214-5880"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascal Leblanc","raw_affiliation_strings":["LaboRe\u0301tro INSERM U758, Unite\u0301 de Virologie Humaine, Ecole Normale Supe\u0301rieure de Lyon, 69364 Lyon Cedex 07, France","Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaboRe\u0301tro INSERM U758, Unite\u0301 de Virologie Humaine, Ecole Normale Supe\u0301rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universite\u0301 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biopo\u0302le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]},{"raw_affiliation_string":"LaboR\u00e9tro INSERM U758, Unit\u00e9 de Virologie Humaine, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR 128 Biosciences Lyon-Gerland, Lyon-Biop\u00f4le, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4405253049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5065925426"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I154526488","https://openalex.org/I4405253049"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":2.8149,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.91400175,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"100","issue":"10","first_page":"603","last_page":"618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.7739999890327454},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9279999732971191},{"id":"https://openalex.org/keywords/n2a-neuroblastoma-cells","display_name":"N2a neuroblastoma cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/prion-infectivity","display_name":"prion infectivity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.7749999761581421},{"id":"https://openalex.org/keywords/viral-envelope-glycoprotein","display_name":"viral envelope glycoprotein","score":0.875},{"id":"https://openalex.org/keywords/prion-transmission","display_name":"prion transmission","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.8343918323516846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7715615630149841},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.7673386335372925},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6880155801773071},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6497993469238281},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5894489288330078},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.492693692445755},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.48033085465431213},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4579258859157562},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.39380019903182983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3733495771884918},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2691150903701782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1408005654811859},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.13198286294937134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10564002394676208},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09711027145385742},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09032043814659119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1042/bc20080025","doi":"https://doi.org/10.1042/bc20080025","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bc20080025","pdf_url":null,"source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},{"id":"pmid:18422484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18422484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00331709v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-00331709","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0248-4900","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00409867v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-00409867","pdf_url":null,"source":{"id":"https://openalex.org/S4377196329","display_name":"HAL Portal Artxiker (Hindustan Aeronautics Limited (India))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088939","host_organization_name":"Hindustan Aeronautics Limited (India)","host_organization_lineage":["https://openalex.org/I4210088939"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0248-4900","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02132257v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-02132257","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0248-4900","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02328557v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02328557","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology of the Cell, 2008, 100 (10), pp.603-618. &#x27E8;10.1042/BC20080025&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W107231475","https://openalex.org/W593173282","https://openalex.org/W1538522759","https://openalex.org/W1590689549","https://openalex.org/W1638530613","https://openalex.org/W1967367827","https://openalex.org/W1976981405","https://openalex.org/W1982187685","https://openalex.org/W1985476822","https://openalex.org/W1986196133","https://openalex.org/W1992359455","https://openalex.org/W1997973599","https://openalex.org/W2000045576","https://openalex.org/W2001091850","https://openalex.org/W2001306764","https://openalex.org/W2007309224","https://openalex.org/W2015616869","https://openalex.org/W2020606280","https://openalex.org/W2020717517","https://openalex.org/W2022056293","https://openalex.org/W2025707488","https://openalex.org/W2028622306","https://openalex.org/W2033268132","https://openalex.org/W2033601813","https://openalex.org/W2041060250","https://openalex.org/W2055313665","https://openalex.org/W2057579163","https://openalex.org/W2060941647","https://openalex.org/W2064293112","https://openalex.org/W2067540111","https://openalex.org/W2068645378","https://openalex.org/W2083333507","https://openalex.org/W2086045833","https://openalex.org/W2090175640","https://openalex.org/W2106235316","https://openalex.org/W2107037134","https://openalex.org/W2107384368","https://openalex.org/W2129062330","https://openalex.org/W2130352925","https://openalex.org/W2135648640","https://openalex.org/W2140415834","https://openalex.org/W4253992140"],"related_works":["https://openalex.org/W2090175640","https://openalex.org/W2028622306","https://openalex.org/W1970413727","https://openalex.org/W2079701803","https://openalex.org/W66253387","https://openalex.org/W2238705702","https://openalex.org/W2106235316","https://openalex.org/W2560150547","https://openalex.org/W2001323244","https://openalex.org/W2948225232"],"abstract_inverted_index":{"BACKGROUND":[0],"INFORMATION:":[1],"TSEs":[2,68],"(transmissible":[3],"spongiform":[4],"encephalopathies)":[5],"are":[6,152],"neurodegenerative":[7],"disorders":[8],"affecting":[9],"humans":[10],"and":[11,65,77,96,137,149,163],"animals.":[12],"PrP(Sc),":[13],"a":[14,70],"conformationally":[15],"altered":[16],"isoform":[17],"of":[18,35,42,48,61,74,92,140,172],"the":[19,28,32,36,49,59,75,78,93,97,106,124,128,181],"normal":[20],"prion":[21,37,50,94,125,147],"protein":[22],"(PrP(C)),":[23],"is":[24,39,84,178],"thought":[25],"to":[26],"be":[27,103],"pathogenic":[29],"agent.":[30],"However,":[31],"biochemical":[33],"composition":[34],"agent":[38,51,76,95,126],"still":[40],"matter":[41],"debate.":[43],"The":[44,113,170],"potential":[45],"transmission":[46],"risk":[47],"through":[52,180],"biological":[53],"fluids":[54],"has":[55],"been":[56],"shown,":[57],"but":[58],"development":[60],"competitive":[62],"diagnostic":[63],"tests":[64],"treatment":[66],"for":[67],"requires":[69],"more":[71],"comprehensive":[72],"knowledge":[73],"cellular":[79,107],"mechanisms":[80],"by":[81,99],"which":[82,100],"it":[83,101],"disseminated.":[85],"With":[86],"this":[87],"aim,":[88],"we":[89],"initiated":[90],"characterization":[91],"pathways":[98],"can":[102],"propagated":[104],"using":[105],"model":[108],"system":[109],"neuroblastoma":[110],"(N2a).":[111],"RESULTS:":[112],"present":[114],"study":[115],"shows":[116],"that":[117,145,158],"N2a":[118,175],"cells":[119],"infected":[120],"with":[121,134,155],"scrapie":[122,150],"release":[123],"into":[127],"cell":[129,176],"culture":[130,177],"medium":[131],"in":[132,174],"association":[133],"exosome-like":[135,156],"structures":[136,157],"viral":[138,160],"particles":[139],"endogenous":[141],"origin.":[142],"We":[143],"found":[144],"both":[146],"proteins":[148],"infectivity":[151],"mainly":[153],"associated":[154],"contain":[159],"envelope":[161],"glycoprotein":[162],"nucleic":[164],"acids,":[165],"such":[166],"as":[167],"RNAs.":[168],"CONCLUSIONS:":[169],"dissemination":[171],"prions":[173],"mediated":[179],"exosomal":[182],"pathway.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
