{"id":"https://openalex.org/W2017677880","doi":"https://doi.org/10.1172/jci117382","title":"Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.","display_name":"Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2017677880","doi":"https://doi.org/10.1172/jci117382","mag":"2017677880","pmid":"https://pubmed.ncbi.nlm.nih.gov/8040319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/296143"},"language":"en","primary_location":{"id":"doi:10.1172/jci117382","doi":"https://doi.org/10.1172/jci117382","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117382","pdf_url":"http://www.jci.org/articles/view/117382/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/117382/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035673687","display_name":"Sharon M. Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Wahl","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109853875","display_name":"J B Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Allen","raw_affiliation_strings":["Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007588636","display_name":"K L Hines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K L Hines","raw_affiliation_strings":["Cellular Immunol- ogy Section , Laboratory of Immunology , NIDR , NIH , Bldg. 30 , Rm. 331 , 9000 Rockville Pike , Bethesda , MD 20892","Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunol- ogy Section , Laboratory of Immunology , NIDR , NIH , Bldg. 30 , Rm. 331 , 9000 Rockville Pike , Bethesda , MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089434852","display_name":"Tomozumi Imamichi","orcid":"https://orcid.org/0000-0002-1474-1796","observed_orcids":["https://orcid.org/0000-0002-1474-1796","https://orcid.org/0009-0007-0910-5297"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Imamichi","raw_affiliation_strings":["Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011266498","display_name":"Allison M. Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Wahl","raw_affiliation_strings":["Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054139","display_name":"Leo T. Furcht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L T Furcht","raw_affiliation_strings":["Biomedical Engineering Center , University of Minnesota , Minneapolis , Minnesota 55455","Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892; and tDepartment of Laboratory Medicine and Pathology, Biomedical Engineering Center,","University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Center , University of Minnesota , Minneapolis , Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892; and tDepartment of Laboratory Medicine and Pathology, Biomedical Engineering Center,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111493206","display_name":"J B McCarthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B McCarthy","raw_affiliation_strings":["Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892; and tDepartment of Laboratory Medicine and Pathology, Biomedical Engineering Center,","University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology , National Institute of Dental Research , National Institutes of Health , Bethesda , Maryland 20892 ; and tDepartment of Laboratory Medicine and Pathology ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892; and tDepartment of Laboratory Medicine and Pathology, Biomedical Engineering Center,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.6339,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.95159236,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"94","issue":"2","first_page":"655","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.9449999928474426},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.972000002861023},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.7319999933242798},{"id":"https://openalex.org/keywords/heparin-binding-domain","display_name":"heparin-binding domain","score":0.9459999799728394},{"id":"https://openalex.org/keywords/integrin-expression","display_name":"integrin expression","score":0.8169999718666077},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/anti-adhesion-therapy","display_name":"anti-adhesion therapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.880726158618927},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.644375205039978},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6150352358818054},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5986167788505554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5283713340759277},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5263965129852295},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5107142925262451},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5095100998878479},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48560968041419983},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4815147817134857},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.45812803506851196},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.4399362802505493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4363255500793457},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3182179927825928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29055923223495483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2831087112426758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2682332396507263},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci117382","doi":"https://doi.org/10.1172/jci117382","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117382","pdf_url":"http://www.jci.org/articles/view/117382/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:296143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/296143","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8040319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8040319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci117382","doi":"https://doi.org/10.1172/jci117382","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117382","pdf_url":"http://www.jci.org/articles/view/117382/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3553420007","display_name":null,"funder_award_id":"CA43924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6635910330","display_name":"METASTASIS INHIBITION BY FIBRONECTIN-TUMOR INTERACTIONS","funder_award_id":"5r01ca043924-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G781776063","display_name":null,"funder_award_id":"CA-21463","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017677880.pdf","grobid_xml":"https://content.openalex.org/works/W2017677880.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W84776641","https://openalex.org/W1510169018","https://openalex.org/W1541410990","https://openalex.org/W1547176846","https://openalex.org/W1558451333","https://openalex.org/W1571254150","https://openalex.org/W1578883193","https://openalex.org/W1666259683","https://openalex.org/W1834186123","https://openalex.org/W1901825802","https://openalex.org/W1912833239","https://openalex.org/W1966286149","https://openalex.org/W1969713456","https://openalex.org/W1972730346","https://openalex.org/W1974342547","https://openalex.org/W1975364338","https://openalex.org/W1980193009","https://openalex.org/W1994521388","https://openalex.org/W2001720727","https://openalex.org/W2001875963","https://openalex.org/W2011207006","https://openalex.org/W2013381560","https://openalex.org/W2028146382","https://openalex.org/W2029681820","https://openalex.org/W2032494769","https://openalex.org/W2034296167","https://openalex.org/W2053315646","https://openalex.org/W2062582674","https://openalex.org/W2071933656","https://openalex.org/W2085005175","https://openalex.org/W2086155704","https://openalex.org/W2086487142","https://openalex.org/W2103467641","https://openalex.org/W2119512066","https://openalex.org/W2130301621","https://openalex.org/W2134812217","https://openalex.org/W2135121318","https://openalex.org/W2139666587","https://openalex.org/W2140969448","https://openalex.org/W2141386649","https://openalex.org/W2144792862","https://openalex.org/W2166158504","https://openalex.org/W2166412027","https://openalex.org/W2418752748","https://openalex.org/W4211006610","https://openalex.org/W4232671899","https://openalex.org/W4246991801","https://openalex.org/W6814570125"],"related_works":["https://openalex.org/W2042928063","https://openalex.org/W2080075129","https://openalex.org/W2347194146","https://openalex.org/W7096411805","https://openalex.org/W2074588418","https://openalex.org/W2054947144","https://openalex.org/W2789623413","https://openalex.org/W2021658323","https://openalex.org/W2041827385","https://openalex.org/W2103064785"],"abstract_inverted_index":{"In":[0],"an":[1,191],"experimental":[2],"model":[3],"of":[4,14,40,63,142,155,170,181],"arthritis,":[5],"increased":[6,45],"leukocyte":[7,74,150],"adhesion":[8,57,75,183,198],"is":[9],"associated":[10],"with":[11],"the":[12,61,99,137,153,163,167,196],"evolution":[13,154],"acute":[15],"and":[16,49,126,152,184,200],"chronic":[17,107,175],"synovial":[18,64,108],"inflammation.":[19],"Whereas":[20],"peripheral":[21],"blood":[22],"mononuclear":[23],"cells":[24],"(PBMC)":[25],"from":[26,35,68,136],"control":[27],"animals":[28,36,82,118],"bind":[29],"minimally":[30],"to":[31,80,89,106,120,147,165],"fibronectin":[32,70,143,172,187],"matrices,":[33],"PBMC":[34],"receiving":[37],"arthropathic":[38],"doses":[39],"bacterial":[41],"cell":[42],"walls":[43],"demonstrate":[44],"integrin":[46],"mRNA":[47],"expression":[48],"enhanced":[50],"adhesion.":[51],"To":[52],"determine":[53],"whether":[54],"this":[55],"augmented":[56],"was":[58],"causal":[59],"in":[60,76,174],"development":[62],"pathology,":[65],"peptides":[66,86,96,134,173,188],"synthesized":[67,135],"several":[69],"domains":[71,104],"which":[72,161],"inhibited":[73],"vitro":[77],"were":[78,95,144],"administered":[79],"arthritic":[81],"either":[83,98],"as":[84],"free":[85],"or":[87,101],"coupled":[88],"a":[90],"carrier":[91],"molecule.":[92],"Not":[93],"only":[94],"containing":[97],"RGD":[100,125],"CS-1":[102],"cell-binding":[103],"inhibitory":[105],"pathology":[109],"(articular":[110],"index":[111],"=":[112],"10.5":[113],"+/-":[114,122,128],"0.3":[115],"for":[116,124,130,194],"untreated":[117],"compared":[119],"1.25":[121],"0.25":[123],"2.5":[127],"0.7":[129],"CS-1),":[131],"but":[132],"three":[133],"carboxy-terminal":[138],"33-kD":[139],"heparin-binding":[140,171],"domain":[141],"also":[145],"found":[146],"significantly":[148],"inhibit":[149],"recruitment":[151,185],"arthritis.":[156],"Based":[157],"on":[158],"these":[159],"data,":[160],"are":[162],"first":[164],"explore":[166],"therapeutic":[168],"potential":[169],"inflammation,":[176],"it":[177],"appears":[178],"that":[179],"antagonism":[180],"cellular":[182],"by":[186],"may":[189],"provide":[190],"important":[192],"mechanism":[193],"modulating":[195],"multi-step":[197],"process":[199],"attenuating":[201],"aberrant":[202],"inflammatory":[203],"responses.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
