{"id":"https://openalex.org/W201766214","doi":null,"title":"Gut fermentation products of insulin-derived prebiotics beneficially modulate markers of tumour progression in human colon tumour cells","display_name":"Gut fermentation products of insulin-derived prebiotics beneficially modulate markers of tumour progression in human colon tumour cells","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W201766214","mag":"201766214"},"language":"en","primary_location":{"id":"mag:201766214","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/13250/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006336721","display_name":"Annett Klinder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annett Klinder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063981565","display_name":"Eva Gietl","orcid":"https://orcid.org/0000-0002-8183-6859","observed_orcids":["https://orcid.org/0000-0002-8183-6859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Gietl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8183-6859","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045026894","display_name":"R\u00f3is\u00edn Hughes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R\u00f3is\u00edn Hughes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042549534","display_name":"N. Jonkers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Jonkers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089338769","display_name":"Per Karlsson","orcid":"https://orcid.org/0000-0003-4841-2672","observed_orcids":["https://orcid.org/0000-0003-4841-2672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Per Karlsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4841-2672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015089367","display_name":"H. McGlyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. McGlyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081699335","display_name":"S. Pistoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Pistoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052942059","display_name":"Kieran Michael Tuohy","orcid":"https://orcid.org/0000-0001-6882-7192","observed_orcids":["https://orcid.org/0000-0001-6882-7192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kieran Tuohy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6882-7192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110244109","display_name":"Joseph James Rafter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Rafter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109387498","display_name":"I.R. Rowland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I.R. Rowland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048956435","display_name":"Jan Van Loo","orcid":"https://orcid.org/0000-0002-6916-1211","observed_orcids":["https://orcid.org/0000-0002-6916-1211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Van Loo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6916-1211","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113611756","display_name":"B.L. Pool-Zobel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.L. Pool-Zobel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5346,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80011373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.949999988079071},{"id":"https://openalex.org/keywords/gut-fermentation","display_name":"gut fermentation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.7770000100135803},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":1.0},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.6399999856948853},{"id":"https://openalex.org/keywords/fructooligosaccharides","display_name":"fructooligosaccharides","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bifidobacterium-animalis-subsp-lactis-bb-12","display_name":"Bifidobacterium animalis subsp. lactis BB-12","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lactobacillus-rhamnosus-gg","display_name":"Lactobacillus rhamnosus GG","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6209999918937683},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.827552080154419},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.7095991969108582},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.5863905549049377},{"id":"https://openalex.org/C2776651480","wikidata":"https://www.wikidata.org/wiki/Q1607640","display_name":"Lactobacillus rhamnosus","level":4,"score":0.566830039024353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5316610336303711},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.5255281329154968},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.517250120639801},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.47099775075912476},{"id":"https://openalex.org/C2777945686","wikidata":"https://www.wikidata.org/wiki/Q4904767","display_name":"Bifidobacterium animalis","level":5,"score":0.45351025462150574},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.4529378414154053},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.4421175420284271},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.42736777663230896},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4270137548446655},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.42576029896736145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.392559677362442},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3345397710800171},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10476177930831909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:201766214","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/13250/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159735787","https://openalex.org/W2089078753","https://openalex.org/W2128082632","https://openalex.org/W2783926019","https://openalex.org/W2103602311","https://openalex.org/W2414751594","https://openalex.org/W2070004832","https://openalex.org/W2324693021","https://openalex.org/W2081046751","https://openalex.org/W2048615215"],"abstract_inverted_index":{"Insulin":[0],"is":[1,20,40],"a":[2,74],"prebiotic":[3],"food":[4],"ingredient,":[5],"which":[6],"suppresses":[7],"colon":[8,63,194,237],"tumour":[9,127,238,244],"growth":[10,131,202,233],"and":[11,25,129,139,161,218,234],"development":[12],"in":[13,68,73,81,236],"rats.":[14],"In":[15],"the":[16,51,115,169,174,205,221,229],"gut":[17,170,222],"lumen,":[18],"it":[19],"fermented":[21,94,116],"to":[22,45,62,231],"lactic":[23,206],"acid":[24],"short":[26],"chain":[27],"fatty":[28],"acids":[29],"(SCFA).":[30],"Of":[31],"these,":[32],"butyrate":[33],"has":[34],"suppressing":[35],"agent":[36],"activities,":[37],"but":[38,213],"little":[39],"known":[41],"concerning":[42],"cellular":[43,59,163],"responses":[44,60],"complex":[46],"fermentation":[47,54,76,149],"samples.":[48],"To":[49],"investigate":[50],"effects":[52,190],"of":[53,56,114,124,186,191,204,211,220,228,243],"products":[55,219],"insulin":[57,88,192],"on":[58,184],"related":[61],"carcinogenesis.":[64],"Fermentations":[65],"were":[66,110,132,141],"performed":[67],"anaerobic":[69],"batch":[70],"cultures":[71],"or":[72,107],"three-stage":[75],"model":[77,171],"that":[78],"simulates":[79],"conditions":[80],"colon-segments":[82],"(proximal,":[83],"transverse,":[84],"distal).":[85],"Substrate":[86],"was":[87,177],"enriched":[89],"with":[90,95,112,145,150,155],"oligofructose":[91],"(Raftilose\u00ae":[92],"Synergy1),":[93],"probiotics":[96,138],"(Bifidobacterium":[97],"lactis":[98],"Bb12,":[99],"Lactobacillus":[100],"rhamnosus":[101],"GG),":[102],"and/or":[103,209],"faecal":[104,151],"inocula.":[105],"HT29":[106],"CaCo-2":[108],"cells":[109,195,239],"incubated":[111],"supernatants":[113,135,154,230],"samples":[117],"(2.5%-25%":[118],"v/v,":[119],"24-72":[120],"hours).":[121],"Cellular":[122],"parameters":[123],"survival,":[125],"differentiation,":[126],"progression,":[128],"invasive":[130],"determined.":[133],"Fermentation":[134],"derived":[136,167],"from":[137,168],"Synergy1":[140],"more":[142],"effective":[143,179],"than":[144],"glucose.":[146],"The":[147,165],"additional":[148],"slurries":[152],"produced":[153],"lower":[156],"toxicity,":[157],"higher":[158,187],"SCFA":[159],"contents,":[160],"distinct":[162],"functions.":[164],"supernatant":[166],"vessel":[172],"representing":[173],"distal":[175],"colon,":[176],"most":[178],"for":[180],"all":[181],"parameters,":[182],"probably":[183],"account":[185],"butyrate-concentrations.":[188],"Biological":[189],"upon":[193],"may":[196],"be":[197],"mediated":[198],"not":[199],"only":[200],"by":[201,215],"stimulation":[203],"acid-producing":[207],"bacteria":[208,217],"production":[210],"butyrate,":[212],"also":[214],"other":[216],"lumen.":[223],"These":[224],"newly":[225],"reported":[226],"properties":[227],"inhibit":[232],"metastases":[235],"are":[240],"important":[241],"mechanisms":[242],"suppression.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}