{"id":"https://openalex.org/W2017660682","doi":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","title":"Urokinase combination chemotherapy in small cell lung cancer. A phase II study","display_name":"Urokinase combination chemotherapy in small cell lung cancer. A phase II study","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2017660682","doi":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","mag":"2017660682","pmid":"https://pubmed.ncbi.nlm.nih.gov/1330286"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","doi":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032986745","display_name":"Felipe \u00c1ngel Calvo","orcid":"https://orcid.org/0000-0001-7574-546X","observed_orcids":["https://orcid.org/0000-0001-7574-546X"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. A. Calvo","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049845875","display_name":"Oscar Fernandez Hidalgo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"O. F. Hidalgo","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111236003","display_name":"F. Gonzalez","orcid":"https://orcid.org/0000-0001-9466-9087","observed_orcids":["https://orcid.org/0000-0001-9466-9087"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. Gonzalez","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109423993","display_name":"Joseba Rebollo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Rebollo","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028314830","display_name":"Salvador Mart\u00edn\u2010Algarra","orcid":"https://orcid.org/0000-0002-3109-8026","observed_orcids":["https://orcid.org/0000-0002-3109-8026"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Martin Algarra","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027382076","display_name":"D. Ortiz de Urbina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D. Ortiz De Urbina","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"Department of Oncology, Cl\u00ednica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021003281","display_name":"Antonio Brugarolas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"A. Brugarolas","raw_affiliation_strings":["Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021003281"],"corresponding_institution_ids":["https://openalex.org/I4210135003"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.8291,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75480937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"70","issue":"11","first_page":"2624","last_page":"2630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9629999995231628},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/thoracic-radiotherapy","display_name":"thoracic radiotherapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/prophylactic-cranial-irradiation","display_name":"prophylactic cranial irradiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.7239999771118164},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7480000257492065},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8529999852180481},{"id":"https://openalex.org/keywords/limited-disease","display_name":"limited disease","score":0.722000002861023},{"id":"https://openalex.org/keywords/extensive-stage-disease","display_name":"extensive disease","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9419868588447571},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.6910268068313599},{"id":"https://openalex.org/C2779562246","wikidata":"https://www.wikidata.org/wiki/Q16918881","display_name":"Prophylactic cranial irradiation","level":4,"score":0.6647838950157166},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6213223934173584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5567775964736938},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5321701169013977},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5189085602760315},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5127276182174683},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.47918879985809326},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.46746137738227844},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4423753619194031},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000206","descriptor_name":"Actuarial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","doi":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19921201)70:11<2624::aid-cncr2820701110>3.0.co;2-4","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:1330286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1330286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"},{"id":"pmh:oai:dadun.unav.edu:10171/68530","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10171/68530","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W117021016","https://openalex.org/W181632512","https://openalex.org/W184742449","https://openalex.org/W1480091719","https://openalex.org/W1491292227","https://openalex.org/W1764986270","https://openalex.org/W1807610754","https://openalex.org/W1895600627","https://openalex.org/W1900867937","https://openalex.org/W1923792259","https://openalex.org/W1962175162","https://openalex.org/W1967317662","https://openalex.org/W1978410072","https://openalex.org/W1996771444","https://openalex.org/W2002938738","https://openalex.org/W2018440902","https://openalex.org/W2020833804","https://openalex.org/W2034553767","https://openalex.org/W2050431827","https://openalex.org/W2063783041","https://openalex.org/W2068747990","https://openalex.org/W2077003696","https://openalex.org/W2084961249","https://openalex.org/W2093536022","https://openalex.org/W2098415065","https://openalex.org/W2103926757","https://openalex.org/W2136320012","https://openalex.org/W2158367760","https://openalex.org/W2198883395","https://openalex.org/W2230155084","https://openalex.org/W2235063564","https://openalex.org/W2266436416","https://openalex.org/W2403585568","https://openalex.org/W2914878951","https://openalex.org/W4255400340"],"related_works":["https://openalex.org/W3034992215","https://openalex.org/W2416339949","https://openalex.org/W2135676478","https://openalex.org/W2460059522","https://openalex.org/W2077003696","https://openalex.org/W1999280354","https://openalex.org/W2471082332","https://openalex.org/W2121983031","https://openalex.org/W2038042148","https://openalex.org/W2005244059"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"METHODS:":[2],"Fifty-one":[3],"patients":[4,67,80,102,124,130,140,155,237],"with":[5,13,45,81,103,115,125,131,141,156,173,180,204,225,234,238,240],"small":[6],"cell":[7],"lung":[8],"cancer":[9],"(SCLC)":[10],"were":[11,56,85,107,120,136,169],"treated":[12],"alternating":[14],"urokinase":[15],"(UK)-cyclophosphamide-doxorubicin":[16],"(Adriamycin,":[17],"Adria":[18],"Laboratories,":[19],"Columbus,":[20],"OH)-vincristine":[21],"and":[22,50,88,112,128,150,162,176,197],"cisplatin-etoposide-vincristine.":[23],"UK":[24],"was":[25,64,202],"given":[26],"as":[27,137],"a":[28,69,205,226],"loading":[29],"dose":[30],"of":[31,189,207,210,229],"3000":[32,38],"micrograms/kg":[33],"body":[34],"weight,":[35],"followed":[36],"by":[37],"micrograms/kg/h":[39],"for":[40],"6":[41],"hours.":[42],"Thoracic":[43],"irradiation":[44,53],"split":[46],"technique":[47],"(46":[48],"Gy)":[49,55],"prophylactic":[51],"cranial":[52],"(25":[54],"administered":[57],"to":[58,191],"responding":[59],"patients.":[60],"A":[61],"second":[62],"staging":[63],"performed":[65],"in":[66,100,122,139,154,232,236],"exhibiting":[68],"clinical":[70],"complete":[71],"response":[72],"(CR)":[73],"after":[74],"1":[75,144,159],"year.":[76],"RESULTS:":[77],"In":[78],"27":[79],"limited":[82,126,142,174,241],"disease,":[83,105,143,158],"there":[84,106],"23":[86],"CR":[87,119],"8":[89],"partial":[90],"responses":[91],"(PR)":[92],"(CR,":[93],"85.1%;":[94,146],"66.2-95.8%":[95],"at":[96],"95%":[97],"confidence":[98],"intervals);":[99],"24":[101],"extensive":[104,132,157,181],"17":[108],"CR,":[109],"4":[110],"PR,":[111],"3":[113,151],"cases":[114],"progression.":[116],"Pathologically":[117],"proven":[118],"observed":[121],"59.2%":[123],"disease":[127],"33.3%":[129],"disease.":[133,242],"Survival":[134],"rates":[135],"follows:":[138],"year,":[145,160],"2":[147,163],"years,":[148,152,164],"55.5%;":[149],"25.9%;":[153],"54.1;":[161],"16.9%.":[165],"Median":[166],"survival":[167],"times":[168],"26.3":[170],"months":[171,178],"(patients":[172,179],"disease)":[175],"13.3":[177],"disease).":[182],"UK-related":[183],"toxic":[184],"effects":[185],"included":[186],"four":[187],"episodes":[188,209],"mild":[190],"moderate":[192],"bleeding,":[193],"one":[194,198],"allergic":[195],"reaction,":[196],"cerebrovascular":[199],"accident.":[200],"Myelotoxicity":[201],"severe,":[203],"median":[206],"two":[208],"Grade":[211],"III-IV":[212],"(World":[213],"Health":[214],"Organization":[215],"classification)":[216],"aplasia":[217],"per":[218],"patient.":[219],"CONCLUSIONS:":[220],"These":[221],"results":[222],"are":[223,245],"consistent":[224],"potential":[227],"benefit":[228],"fibrinolytic":[230],"therapy":[231],"combination":[233],"chemotherapy":[235],"SCLC":[239],"Additional":[243],"trials":[244],"indicated.":[246]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
