{"id":"https://openalex.org/W2017643275","doi":"https://doi.org/10.1021/bi00463a003","title":"Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments","display_name":"Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments","publication_year":1990,"publication_date":"1990-03-20","ids":{"openalex":"https://openalex.org/W2017643275","doi":"https://doi.org/10.1021/bi00463a003","mag":"2017643275","pmid":"https://pubmed.ncbi.nlm.nih.gov/2346740"},"language":"en","primary_location":{"id":"doi:10.1021/bi00463a003","doi":"https://doi.org/10.1021/bi00463a003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00463a003","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017643275"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051330133","display_name":"Kurt J. Halverson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt Halverson","raw_affiliation_strings":["Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007554690","display_name":"Paul E. Fraser","orcid":"https://orcid.org/0000-0003-1227-4239","observed_orcids":["https://orcid.org/0000-0003-1227-4239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul E. Fraser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039151870","display_name":"Daniel A. Kirschner","orcid":"https://orcid.org/0000-0003-3498-1452","observed_orcids":["https://orcid.org/0000-0003-3498-1452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel A. Kirschner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005020605","display_name":"Peter T. Lansbury","orcid":"https://orcid.org/0000-0001-6462-5024","observed_orcids":["https://orcid.org/0000-0001-6462-5024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter T. Lansbury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.9223,"has_fulltext":false,"cited_by_count":294,"citation_normalized_percentile":{"value":0.97653215,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"11","first_page":"2639","last_page":"2644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9100000262260437},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8299999833106995},{"id":"https://openalex.org/keywords/peptide-fibrillation","display_name":"peptide fibrillation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/peptide-solubility","display_name":"peptide solubility","score":0.921999990940094},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.6600000262260437},{"id":"https://openalex.org/keywords/fibril-nucleation","display_name":"fibril nucleation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6627981662750244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5279715657234192},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.49889111518859863},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.440775066614151},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.4162452816963196},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3579521179199219},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3102527856826782},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.2612977921962738},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00463a003","doi":"https://doi.org/10.1021/bi00463a003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00463a003","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:2346740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2346740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6283936909","display_name":"ABNORMAL FIBROUS ASSEMBLIES OF ALZHEIMERS DISEASE","funder_award_id":"R01AG008572","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1542067597","https://openalex.org/W1885793991","https://openalex.org/W1934853983","https://openalex.org/W1966582570","https://openalex.org/W1974179395","https://openalex.org/W1975862549","https://openalex.org/W1982168666","https://openalex.org/W1987368313","https://openalex.org/W1988207214","https://openalex.org/W1988478867","https://openalex.org/W1994595152","https://openalex.org/W1996055359","https://openalex.org/W2004297557","https://openalex.org/W2013833879","https://openalex.org/W2019369720","https://openalex.org/W2021417643","https://openalex.org/W2024903115","https://openalex.org/W2032920422","https://openalex.org/W2036164670","https://openalex.org/W2038701321","https://openalex.org/W2040776655","https://openalex.org/W2041808750","https://openalex.org/W2046847750","https://openalex.org/W2049535318","https://openalex.org/W2059062385","https://openalex.org/W2059457068","https://openalex.org/W2064093411","https://openalex.org/W2067681993","https://openalex.org/W2067961010","https://openalex.org/W2081881251","https://openalex.org/W2084015178","https://openalex.org/W2087991042","https://openalex.org/W2095065265","https://openalex.org/W2104834142","https://openalex.org/W2126441275","https://openalex.org/W2148568069","https://openalex.org/W2167839173","https://openalex.org/W2168780779","https://openalex.org/W2173534031","https://openalex.org/W2345949170","https://openalex.org/W2415813899","https://openalex.org/W2460248598","https://openalex.org/W2950453519"],"related_works":["https://openalex.org/W1516306407","https://openalex.org/W1982635793","https://openalex.org/W1773701686","https://openalex.org/W1982695192","https://openalex.org/W2001318407","https://openalex.org/W2130144581","https://openalex.org/W2032665239","https://openalex.org/W2059062385","https://openalex.org/W2135493625","https://openalex.org/W31577248"],"abstract_inverted_index":{"The":[0,82],"amyloid":[1,12,201],"beta-protein":[2,190],"(1-42)":[3],"is":[4,181],"a":[5,134,182],"major":[6,183],"constituent":[7],"of":[8,18,20,34,98,152,162,173,188,196],"the":[9,16,29,35,106,110,138,148,160,168,186,189,194,197],"abnormal":[10],"extracellular":[11],"plaque":[13],"that":[14,105,167,199],"characterizes":[15],"brains":[17],"victims":[19],"Alzheimer's":[21],"disease.":[22],"Two":[23],"peptides,":[24],"with":[25],"sequences":[26],"derived":[27],"from":[28,123],"previously":[30],"unexplored":[31],"C-terminal":[32],"region":[33],"beta-protein,":[36],"beta":[37,41,57,69,126,141,153],"26-33":[38,58],"(H2N-SNKGAIIG-CO2H)":[39],"and":[40,46,48,51,90,118,191],"34-42":[42,70,142,154],"(H2N-LMVGGVVIA-CO2H),":[43],"were":[44,54],"synthesized":[45],"purified,":[47],"their":[49],"solubility":[50,117],"conformational":[52],"properties":[53],"analyzed.":[55],"Peptide":[56],"was":[59,71,112,121],"found":[60],"to":[61,176,185],"be":[62],"freely":[63],"soluble":[64],"in":[65,74,109,130,147,155,159],"water;":[66],"however,":[67],"peptide":[68,107,140],"virtually":[72],"insoluble":[73],"aqueous":[75],"media,":[76],"including":[77],"6":[78],"M":[79],"guanidinium":[80],"thiocyanate.":[81],"peptides":[83],"formed":[84],"assemblies":[85],"having":[86],"distinct":[87],"fibrillar":[88],"morphologies":[89],"different":[91],"dimensions":[92],"as":[93,133],"observed":[94],"by":[95,171],"electron":[96],"microscopy":[97],"negatively":[99],"stained":[100],"samples.":[101],"X-ray":[102],"diffraction":[103],"revealed":[104],"conformation":[108],"fibrils":[111,198],"cross-beta.":[113],"A":[114],"correlation":[115],"between":[116],"beta-structure":[119],"formation":[120,195],"inferred":[122],"FTIR":[124],"studies:":[125],"26-33,":[127],"when":[128],"dissolved":[129],"water,":[131],"existed":[132],"random":[135],"coil,":[136],"whereas":[137],"water-insoluble":[139],"possessed":[143],"antiparallel":[144],"beta-sheet":[145],"structure":[146],"solid":[149],"state.":[150],"Solubilization":[151],"organic":[156],"media":[157],"resulted":[158],"disappearance":[161],"beta-structure.":[163],"These":[164],"data":[165],"suggest":[166],"sequence":[169],"34-42,":[170],"virtue":[172],"its":[174],"ability":[175],"form":[177],"unusually":[178],"stable":[179],"beta-structure,":[180],"contributor":[184],"insolubility":[187],"may":[192],"nucleate":[193],"constitute":[200],"plaque.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
