{"id":"https://openalex.org/W2017614536","doi":"https://doi.org/10.3109/15622975.2011.585662","title":"Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder","display_name":"Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder","publication_year":2011,"publication_date":"2011-08-03","ids":{"openalex":"https://openalex.org/W2017614536","doi":"https://doi.org/10.3109/15622975.2011.585662","mag":"2017614536","pmid":"https://pubmed.ncbi.nlm.nih.gov/21812622"},"language":"en","primary_location":{"id":"doi:10.3109/15622975.2011.585662","doi":"https://doi.org/10.3109/15622975.2011.585662","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15622975.2011.585662","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069453054","display_name":"Jigar Jogia","orcid":"https://orcid.org/0000-0003-1799-1245","observed_orcids":["https://orcid.org/0000-0003-1799-1245"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jigar Jogia","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Department of Psychosis Studies, Kings College London, London, UK. jigar.jogia@kcl.ac.uk","Section of Neurobiology of Psychosis, Department of Psychosis Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Department of Psychosis Studies, Kings College London, London, UK. jigar.jogia@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Department of Psychosis Studies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006464992","display_name":"Danai Dima","orcid":"https://orcid.org/0000-0002-2598-0952","observed_orcids":["https://orcid.org/0000-0002-2598-0952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danai Dima","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Department of Psychosis Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Department of Psychosis Studies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044286845","display_name":"Veena Kumari","orcid":"https://orcid.org/0000-0002-9635-5505","observed_orcids":["https://orcid.org/0000-0002-9635-5505"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Veena Kumari","raw_affiliation_strings":["Psychology Department, Institute of Psychiatry, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology Department, Institute of Psychiatry, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015454510","display_name":"Sophia Frangou","orcid":"https://orcid.org/0000-0002-3210-6470","observed_orcids":["https://orcid.org/0000-0002-3210-6470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Frangou","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Department of Psychosis Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Department of Psychosis Studies","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069453054"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":2.7857,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.89604141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"8","first_page":"605","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/reward-processing","display_name":"reward processing","score":0.8930000066757202},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9950000047683716},{"id":"https://openalex.org/keywords/emotion-dysregulation","display_name":"emotional dysregulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/iowa-gambling-task","display_name":"Iowa Gambling Task","score":0.7730000019073486},{"id":"https://openalex.org/keywords/n-back-task","display_name":"n-back task","score":0.9670000076293945},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cognitive-control","display_name":"cognitive control","score":0.6340000033378601},{"id":"https://openalex.org/keywords/functional-brain-abnormalities","display_name":"functional brain abnormalities","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7490162253379822},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.715667188167572},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6985259056091309},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5992472171783447},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.5680440068244934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5014417171478271},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4750009775161743},{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.4471021592617035},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3848057985305786},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3811817765235901},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.36631566286087036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17442333698272705}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3109/15622975.2011.585662","doi":"https://doi.org/10.3109/15622975.2011.585662","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15622975.2011.585662","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:21812622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21812622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/4632adf6-23a0-4d78-9d6a-cab42114a746","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/4632adf6-23a0-4d78-9d6a-cab42114a746","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jogia, J, Dima, D, Kumari, V & Frangou, S 2011, 'Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder', World Journal of Biological Psychiatry, vol. 13, no. 8, pp. 605-615. https://doi.org/10.3109/15622975.2011.585662","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W618310327","https://openalex.org/W1654467375","https://openalex.org/W1746299476","https://openalex.org/W1909424429","https://openalex.org/W1970090972","https://openalex.org/W1970242526","https://openalex.org/W1972854636","https://openalex.org/W1978135580","https://openalex.org/W1978194857","https://openalex.org/W1982642967","https://openalex.org/W1984051795","https://openalex.org/W1988764534","https://openalex.org/W1989701909","https://openalex.org/W1990159138","https://openalex.org/W1992149782","https://openalex.org/W1994123042","https://openalex.org/W1994350513","https://openalex.org/W1995907546","https://openalex.org/W2000509639","https://openalex.org/W2000697043","https://openalex.org/W2002162597","https://openalex.org/W2002337595","https://openalex.org/W2005391856","https://openalex.org/W2018662679","https://openalex.org/W2019782389","https://openalex.org/W2021300708","https://openalex.org/W2021620877","https://openalex.org/W2030645204","https://openalex.org/W2033461112","https://openalex.org/W2033782114","https://openalex.org/W2035994742","https://openalex.org/W2040533544","https://openalex.org/W2042105050","https://openalex.org/W2045159655","https://openalex.org/W2046774605","https://openalex.org/W2070218409","https://openalex.org/W2071744520","https://openalex.org/W2090571857","https://openalex.org/W2093072166","https://openalex.org/W2095068146","https://openalex.org/W2101401693","https://openalex.org/W2105218783","https://openalex.org/W2105389170","https://openalex.org/W2111464173","https://openalex.org/W2114613490","https://openalex.org/W2115789347","https://openalex.org/W2125972603","https://openalex.org/W2130434337","https://openalex.org/W2133105630","https://openalex.org/W2139843843","https://openalex.org/W2140193616","https://openalex.org/W2146414775","https://openalex.org/W2154540835","https://openalex.org/W2155857408","https://openalex.org/W2159011576","https://openalex.org/W2167420848","https://openalex.org/W2167659819","https://openalex.org/W2170256757","https://openalex.org/W3089149994"],"related_works":["https://openalex.org/W2012857199","https://openalex.org/W2556153753","https://openalex.org/W2058800473","https://openalex.org/W1994123042","https://openalex.org/W2140696380","https://openalex.org/W2140193616","https://openalex.org/W2040263804","https://openalex.org/W1977069738","https://openalex.org/W2479792564","https://openalex.org/W2039872711"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Emotional":[1],"dysregulation":[2],"in":[3,17,29,55,139,150,175,178,184],"bipolar":[4,58,65,104,169],"disorder":[5,66,105,170],"is":[6,181],"thought":[7],"to":[8,38],"arise":[9],"from":[10],"dysfunction":[11,163],"within":[12,26,112],"prefrontal":[13,116],"cortical":[14],"regions":[15,27,176],"involved":[16,177],"cognitive":[18],"control":[19],"coupled":[20],"with":[21,57,103,118],"increased":[22],"or":[23],"aberrant":[24],"activation":[25,138],"engaged":[28],"emotional":[30,179,191],"processing.":[31],"The":[32],"aim":[33],"of":[34,45,109,120],"this":[35],"study":[36],"was":[37,84],"determine":[39],"the":[40,87,93,113,123,140,145,151,154],"common":[41],"and":[42,51,68,77,92,128,149,171],"distinct":[43],"patterns":[44],"functional":[46],"brain":[47],"abnormalities":[48],"during":[49,86,144,153],"reward":[50,127],"working":[52,95,129],"memory":[53,96,130],"processing":[54],"patients":[56,67,102,134],"disorder.":[59],"METHODS:":[60],"Participants":[61],"were":[62],"36":[63],"euthymic":[64],"37":[69],"healthy":[70],"comparison":[71],"subjects":[72],"matched":[73],"for":[74,126],"age,":[75],"sex":[76],"IQ.":[78],"Functional":[79],"magnetic":[80],"resonance":[81],"imaging":[82],"(fMRI)":[83],"conducted":[85],"Iowa":[88,146],"Gambling":[89,147],"Task":[90,148],"(IGT)":[91],"n-back":[94,155],"task.":[97,156],"RESULTS:":[98],"During":[99],"both":[100],"tasks,":[101],"demonstrated":[106],"a":[107,165],"pattern":[108],"inefficient":[110],"engagement":[111],"ventral":[114,161],"frontopolar":[115,162],"cortex":[117,143],"evidence":[119],"segregation":[121],"along":[122],"medial-lateral":[124],"dimension":[125],"processing,":[131],"respectively.":[132],"Moreover,":[133],"also":[135],"showed":[136],"greater":[137],"anterior":[141],"cingulate":[142],"insula":[152],"CONCLUSIONS:":[157],"Our":[158],"data":[159],"implicate":[160],"as":[164],"core":[166],"abnormality":[167],"underpinning":[168],"confirm":[172],"that":[173,186],"overactivation":[174],"arousal":[180],"present":[182],"even":[183],"tasks":[185],"do":[187],"not":[188],"typically":[189],"engage":[190],"systems.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
