{"id":"https://openalex.org/W2017611344","doi":"https://doi.org/10.1016/s0361-9230(00)00274-4","title":"Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion","display_name":"Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2017611344","doi":"https://doi.org/10.1016/s0361-9230(00)00274-4","mag":"2017611344","pmid":"https://pubmed.ncbi.nlm.nih.gov/10922516"},"language":"en","primary_location":{"id":"doi:10.1016/s0361-9230(00)00274-4","doi":"https://doi.org/10.1016/s0361-9230(00)00274-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0361-9230(00)00274-4","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108485105","display_name":"Seong\u2010Wook Yun","orcid":"https://orcid.org/0009-0003-8788-7969","observed_orcids":["https://orcid.org/0009-0003-8788-7969"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Seong-Wook Yun","raw_affiliation_strings":["Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049822573","display_name":"Ulrich G\u00e4rtner","orcid":"https://orcid.org/0009-0002-9808-3985","observed_orcids":["https://orcid.org/0009-0002-9808-3985"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich G\u00e4rtner","raw_affiliation_strings":["Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003366066","display_name":"Thomas Arendt","orcid":"https://orcid.org/0000-0003-4553-1625","observed_orcids":["https://orcid.org/0000-0003-4553-1625"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Arendt","raw_affiliation_strings":["Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104056907","display_name":"Siegfried Hoyer","orcid":"https://orcid.org/0000-0002-3135-3242","observed_orcids":["https://orcid.org/0000-0002-3135-3242"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Siegfried Hoyer","raw_affiliation_strings":["Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104056907"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":0.2881,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.54125914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"52","issue":"5","first_page":"371","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-neurotoxicity","display_name":"lead neurotoxicity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/low-level-lead-exposure","display_name":"low-level lead exposure","score":0.9229999780654907},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/energy-depletion","display_name":"energy depletion","score":0.656000018119812},{"id":"https://openalex.org/keywords/middle-aged-rats","display_name":"middle-aged rats","score":0.7590000033378601},{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/astroglial-activation","display_name":"astroglial activation","score":0.875},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.9570000171661377},{"id":"https://openalex.org/keywords/age-related-neurological-diseases","display_name":"age-related neurological diseases","score":0.574999988079071},{"id":"https://openalex.org/keywords/brain-vulnerability","display_name":"brain vulnerability","score":0.39500001072883606},{"id":"https://openalex.org/keywords/blood-lead-levels","display_name":"blood lead levels","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6453894972801208},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6298902034759521},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.511083722114563},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5068023800849915},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.49802732467651367},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.47759103775024414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4513291120529175},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41597461700439453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3096276521682739},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2516407072544098}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0361-9230(00)00274-4","doi":"https://doi.org/10.1016/s0361-9230(00)00274-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0361-9230(00)00274-4","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},{"id":"pmid:10922516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10922516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research bulletin","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W2393449","https://openalex.org/W66210110","https://openalex.org/W105291650","https://openalex.org/W174239334","https://openalex.org/W221418928","https://openalex.org/W1502456623","https://openalex.org/W1516559507","https://openalex.org/W1563608944","https://openalex.org/W1676822859","https://openalex.org/W1925799544","https://openalex.org/W1965367126","https://openalex.org/W1970429382","https://openalex.org/W1972591818","https://openalex.org/W1975257597","https://openalex.org/W1976647278","https://openalex.org/W1980190852","https://openalex.org/W1985714650","https://openalex.org/W1987438759","https://openalex.org/W1999043108","https://openalex.org/W2001715624","https://openalex.org/W2003189253","https://openalex.org/W2004580097","https://openalex.org/W2005646330","https://openalex.org/W2009012421","https://openalex.org/W2011273992","https://openalex.org/W2015284998","https://openalex.org/W2016231653","https://openalex.org/W2016266703","https://openalex.org/W2020437934","https://openalex.org/W2024422704","https://openalex.org/W2028564653","https://openalex.org/W2034661401","https://openalex.org/W2036326457","https://openalex.org/W2037343020","https://openalex.org/W2041614836","https://openalex.org/W2043230770","https://openalex.org/W2043968522","https://openalex.org/W2045806294","https://openalex.org/W2046975858","https://openalex.org/W2047074035","https://openalex.org/W2047275732","https://openalex.org/W2051376391","https://openalex.org/W2051793369","https://openalex.org/W2062989356","https://openalex.org/W2065023418","https://openalex.org/W2065146872","https://openalex.org/W2065641294","https://openalex.org/W2069510356","https://openalex.org/W2076901935","https://openalex.org/W2080875376","https://openalex.org/W2086637491","https://openalex.org/W2092980052","https://openalex.org/W2131651601","https://openalex.org/W2141999573","https://openalex.org/W2142695526","https://openalex.org/W2143017869","https://openalex.org/W2143240446","https://openalex.org/W2160720263","https://openalex.org/W2396563888","https://openalex.org/W2409812107","https://openalex.org/W2438786899","https://openalex.org/W2467214428","https://openalex.org/W2506034187","https://openalex.org/W2798748181","https://openalex.org/W4246367259","https://openalex.org/W4405205335"],"related_works":["https://openalex.org/W2145222145","https://openalex.org/W2027951202","https://openalex.org/W2072705123","https://openalex.org/W4223592126","https://openalex.org/W2989751735","https://openalex.org/W2755874706","https://openalex.org/W4384344471","https://openalex.org/W2064413054","https://openalex.org/W1987438759","https://openalex.org/W2074960639"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
