{"id":"https://openalex.org/W2017599618","doi":"https://doi.org/10.1038/359328a0","title":"Requirement for a functional Rb-1 gene in murine development","display_name":"Requirement for a functional Rb-1 gene in murine development","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2017599618","doi":"https://doi.org/10.1038/359328a0","mag":"2017599618","pmid":"https://pubmed.ncbi.nlm.nih.gov/1406937"},"language":"en","primary_location":{"id":"doi:10.1038/359328a0","doi":"https://doi.org/10.1038/359328a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/359328a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017599618"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001013132","display_name":"Alan Richard Clarke","orcid":"https://orcid.org/0000-0002-4281-426X","observed_orcids":["https://orcid.org/0000-0002-4281-426X"]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan R. Clarke","raw_affiliation_strings":["Department of Pathology, University of Edinburgh, UK","Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113544632","display_name":"Els Robanus Maandag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Els Robanus Maandag","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065581116","display_name":"Marian A. van ROON","orcid":"https://orcid.org/0000-0002-4643-9946","observed_orcids":["https://orcid.org/0000-0002-4643-9946"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marian van Roon","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023108411","display_name":"Nathalie M. T. van der Lugt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nathalie M. T. van der Lugt","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018423614","display_name":"Martin van der Valk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin van der Valk","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109862501","display_name":"Martin Hooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin L. Hooper","raw_affiliation_strings":["AFRC Centre for Genome Research, University of Edinburgh, Edinburgh, UK","Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFRC Centre for Genome Research, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028894540","display_name":"Anton J. M. Berns","orcid":"https://orcid.org/0000-0003-2194-1988","observed_orcids":["https://orcid.org/0000-0003-2194-1988"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anton Berns","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575753","display_name":"Hein te Rielef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hein te Rielef","raw_affiliation_strings":["Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":32.5771,"has_fulltext":false,"cited_by_count":1011,"citation_normalized_percentile":{"value":0.99737853,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"359","issue":"6393","first_page":"328","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rb1-gene","display_name":"RB1 gene","score":0.7630000114440918},{"id":"https://openalex.org/keywords/retinoblastoma","display_name":"retinoblastoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.4959999918937683},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.800000011920929},{"id":"https://openalex.org/keywords/neural-development","display_name":"neural development","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5960000157356262},{"id":"https://openalex.org/keywords/knudson-s-two-hit-hypothesis","display_name":"Knudson's two-hit hypothesis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/heterozygous-mice","display_name":"heterozygous mice","score":0.6740000247955322},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7496829032897949},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.713117241859436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6206200122833252},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6170302629470825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5157073140144348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5152130722999573},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4823317229747772},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.46689116954803467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4585783779621124},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.41353797912597656},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.36999350786209106},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2499505877494812}],"mesh":[{"descriptor_ui":"D000015","descriptor_name":"Abnormalities, Multiple","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D000015","descriptor_name":"Abnormalities, Multiple","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/359328a0","doi":"https://doi.org/10.1038/359328a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/359328a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:1406937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1406937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W14762771","https://openalex.org/W1536906002","https://openalex.org/W1970528551","https://openalex.org/W1973304749","https://openalex.org/W1975572622","https://openalex.org/W1983237714","https://openalex.org/W1984414187","https://openalex.org/W1992160731","https://openalex.org/W1993834457","https://openalex.org/W2013876337","https://openalex.org/W2018855387","https://openalex.org/W2025444976","https://openalex.org/W2028352245","https://openalex.org/W2040976250","https://openalex.org/W2042934065","https://openalex.org/W2053700159","https://openalex.org/W2063367127","https://openalex.org/W2077858999","https://openalex.org/W2086322317","https://openalex.org/W2092543937","https://openalex.org/W2092806325","https://openalex.org/W2101710059","https://openalex.org/W2126068691","https://openalex.org/W2138214907","https://openalex.org/W2140558717","https://openalex.org/W2149263697","https://openalex.org/W2168504426","https://openalex.org/W2340379762","https://openalex.org/W2464887428"],"related_works":["https://openalex.org/W2267147772","https://openalex.org/W2092543937","https://openalex.org/W2063367127","https://openalex.org/W2148209107","https://openalex.org/W4403982821","https://openalex.org/W2950626489","https://openalex.org/W2062419017","https://openalex.org/W2122039072","https://openalex.org/W2086096251","https://openalex.org/W2405283211"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}