{"id":"https://openalex.org/W2017587668","doi":"https://doi.org/10.1089/jir.1998.18.273","title":"Prolonged Allograft Survival in Cynomolgus Monkeys Treated with a Monoclonal Antibody to the Human Type I Interferon Receptor and Low Doses of Cyclosporine","display_name":"Prolonged Allograft Survival in Cynomolgus Monkeys Treated with a Monoclonal Antibody to the Human Type I Interferon Receptor and Low Doses of Cyclosporine","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2017587668","doi":"https://doi.org/10.1089/jir.1998.18.273","mag":"2017587668","pmid":"https://pubmed.ncbi.nlm.nih.gov/9568730"},"language":"en","primary_location":{"id":"doi:10.1089/jir.1998.18.273","doi":"https://doi.org/10.1089/jir.1998.18.273","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.1998.18.273","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108349202","display_name":"Eric Jacob Benizri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ERIC BENIZRI","raw_affiliation_strings":["Laboratoire de Recherches Chirurgicales, Universit\u00e9 de Nice Sophia-Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Recherches Chirurgicales, Universit\u00e9 de Nice Sophia-Antipolis, France","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042471747","display_name":"Jean Gugenheim","orcid":"https://orcid.org/0000-0002-2624-3014","observed_orcids":["https://orcid.org/0000-0002-2624-3014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JEAN GUGENHEIM","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074258023","display_name":"Ahmed Lasfar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AHMED LASFAR","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833111","display_name":"Pierre Eid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PIERRE EID","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111833964","display_name":"Brigitte Blanchard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BRIGITTE BLANCHARD","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006415762","display_name":"Christophe Lallemand","orcid":"https://orcid.org/0000-0001-5965-2482","observed_orcids":["https://orcid.org/0000-0001-5965-2482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHRISTOPHE LALLEMAND","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081955768","display_name":"Micha\u00ebl G. Tovey","orcid":"https://orcid.org/0000-0002-3058-0494","observed_orcids":["https://orcid.org/0000-0002-3058-0494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MICHAEL G. TOVEY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3094,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79399342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"4","first_page":"273","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.21979999542236328,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha-receptor","display_name":"interferon alpha receptor","score":0.777999997138977},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ifnar1","display_name":"IFNAR1","score":0.718999981880188},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/skin-allograft-survival","display_name":"skin allograft survival","score":0.8859999775886536},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mhc-class-i-and-ii-expression","display_name":"MHC class I and II expression","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7982781529426575},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6163393259048462},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5847197771072388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5819240808486938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5783253908157349},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5499781370162964},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49289441108703613},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47824302315711975},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42203840613365173},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42179951071739197},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41789332032203674},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09878069162368774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jir.1998.18.273","doi":"https://doi.org/10.1089/jir.1998.18.273","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.1998.18.273","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:9568730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W133908433","https://openalex.org/W960353326","https://openalex.org/W1482175312","https://openalex.org/W1539606439","https://openalex.org/W1552058470","https://openalex.org/W1589013728","https://openalex.org/W1677393577","https://openalex.org/W1871479351","https://openalex.org/W1977125391","https://openalex.org/W1982022796","https://openalex.org/W1984754431","https://openalex.org/W2004829503","https://openalex.org/W2015440478","https://openalex.org/W2020903680","https://openalex.org/W2029275361","https://openalex.org/W2031089158","https://openalex.org/W2032739957","https://openalex.org/W2033725996","https://openalex.org/W2039766781","https://openalex.org/W2042511952","https://openalex.org/W2049443386","https://openalex.org/W2054083392","https://openalex.org/W2055327047","https://openalex.org/W2065987343","https://openalex.org/W2068489286","https://openalex.org/W2075342615","https://openalex.org/W2078240230","https://openalex.org/W2083887299","https://openalex.org/W2122708834","https://openalex.org/W2131656392","https://openalex.org/W2136098448","https://openalex.org/W2138109360","https://openalex.org/W2146520624","https://openalex.org/W2166709198","https://openalex.org/W2188625919","https://openalex.org/W2395482576","https://openalex.org/W4210657423","https://openalex.org/W4242337277","https://openalex.org/W4255496125"],"related_works":["https://openalex.org/W1871479351","https://openalex.org/W4242337277","https://openalex.org/W1982022796","https://openalex.org/W2060516601","https://openalex.org/W2412227245","https://openalex.org/W2413824653","https://openalex.org/W7213338612","https://openalex.org/W84090966","https://openalex.org/W2013840807","https://openalex.org/W2058942284"],"abstract_inverted_index":{"A":[0],"monoclonal":[1],"antibody":[2],"(mAb)":[3],"directed":[4],"against":[5],"the":[6,10,14,24,75,86,95,100,104,119,158],"extracellular":[7],"domain":[8],"of":[9,13,23,35,40,65,77,80,97,99,118,142,151,160],"IFNAR1":[11],"chain":[12],"human":[15,161],"interferon-alpha":[16],"(IFN-alpha)":[17],"receptor":[18],"(IFN-alphaR),":[19],"which":[20,129],"inhibits":[21],"activation":[22,117],"Jak-Stat":[25,120],"signal":[26,121],"transduction":[27,122],"pathway,":[28],"administered":[29],"together":[30,110,146],"with":[31,56,103,111,147],"a":[32,148],"subeffective":[33,149],"dose":[34,150],"cyclosporine":[36,60],"induced":[37],"prolonged":[38],"survival":[39],"skin":[41],"allografts":[42],"in":[43,94,124],"major":[44],"histocompatibility":[45],"complex":[46],"(MHC)":[47],"divergent":[48],"cynomolgus":[49],"monkeys.":[50],"Skin":[51],"biopsies":[52],"from":[53],"animals":[54,101],"treated":[55,102],"anti-IFN-alphaR":[57,105,114],"mAb":[58,90,106,115],"and":[59,69,74,133],"revealed":[61],"very":[62],"low":[63],"levels":[64],"MHC":[66],"class":[67,70],"I":[68],"II":[71],"antigen":[72],"expression":[73],"absence":[76],"histologic":[78],"signs":[79],"rejection.":[81,163],"Monkey":[82],"antibodies":[83],"(IgG)":[84],"to":[85],"mouse":[87],"antihuman":[88],"IFN-alphaR":[89],"were":[91],"not":[92],"detected":[93],"serum":[96],"any":[98],"either":[107],"alone":[108],"or":[109],"cyclosporine.":[112],"The":[113],"abrogated":[116],"pathway":[123],"IFN-treated":[125],"cells.":[126],"These":[127],"results,":[128],"show":[130],"that":[131],"selective":[132],"long-lasting":[134],"immunosuppression":[135],"can":[136],"be":[137],"obtained":[138],"by":[139],"short-term":[140],"administration":[141],"an":[143],"IFN-alpha":[144],"antagonist":[145],"cyclosporine,":[152],"may":[153],"have":[154],"important":[155],"implications":[156],"for":[157],"therapy":[159],"allograft":[162]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}