{"id":"https://openalex.org/W2017582941","doi":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","title":"The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA","display_name":"The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2017582941","doi":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","mag":"2017582941","pmid":"https://pubmed.ncbi.nlm.nih.gov/10897014"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","doi":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820000701%2989%3A1%3C171%3A%3AAID-CNCR22%3E3.0.CO%3B2-O","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820000701%2989%3A1%3C171%3A%3AAID-CNCR22%3E3.0.CO%3B2-O","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003551118","display_name":"Chandrika Jayanthi Piyathilake","orcid":"https://orcid.org/0000-0003-3857-7035","observed_orcids":["https://orcid.org/0000-0003-3857-7035"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chandrika J. Piyathilake","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA","Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033599611","display_name":"Walter C. Bell","orcid":"https://orcid.org/0000-0003-1088-7488","observed_orcids":["https://orcid.org/0000-0003-1088-7488"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter C. Bell","raw_affiliation_strings":["Department of Pathology; University of Alabama at Birmingham, Birmingham, Alabama","Department of Pathology","University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology; University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065302439","display_name":"Gary L. Johanning","orcid":"https://orcid.org/0000-0002-2982-7197","observed_orcids":["https://orcid.org/0000-0002-2982-7197"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Johanning","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110176888","display_name":"Phillip E. Cornwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip E. Cornwell","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020344819","display_name":"Douglas Corbett Heimburger","orcid":"https://orcid.org/0000-0003-3551-9710","observed_orcids":["https://orcid.org/0000-0003-3551-9710"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Heimburger","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["Department of Pathology; University of Alabama at Birmingham, Birmingham, Alabama","Department of Pathology","University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology; University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003551118"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":3.1782,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.9093791,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"89","issue":"1","first_page":"171","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/global-dna-methylation","display_name":"global DNA methylation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.5659999847412109},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.9454030990600586},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5730079412460327},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.475761353969574},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.46347248554229736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4344547390937805},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.4202342927455902},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41987791657447815},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.41487500071525574},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37439215183258057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3554350733757019},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29458367824554443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28327786922454834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21888962388038635},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10598921775817871},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08332079648971558},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","doi":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820000701%2989%3A1%3C171%3A%3AAID-CNCR22%3E3.0.CO%3B2-O","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:10897014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10897014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","doi":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(20000701)89:1<171::aid-cncr22>3.0.co;2-o","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820000701%2989%3A1%3C171%3A%3AAID-CNCR22%3E3.0.CO%3B2-O","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2851653708","display_name":"LOCALIZED VITAMIN DEFICIENCIES AND RISK FOR LUNG CANCER","funder_award_id":"K07CA070160","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7728541047","display_name":null,"funder_award_id":"1P50 11910-0351","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017582941.pdf","grobid_xml":"https://content.openalex.org/works/W2017582941.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W27200377","https://openalex.org/W1552528612","https://openalex.org/W1571666545","https://openalex.org/W1901952501","https://openalex.org/W1909602368","https://openalex.org/W1947421187","https://openalex.org/W1955052427","https://openalex.org/W1961815946","https://openalex.org/W1966010051","https://openalex.org/W1974359182","https://openalex.org/W1974747095","https://openalex.org/W1983145747","https://openalex.org/W2006911307","https://openalex.org/W2010756713","https://openalex.org/W2011240110","https://openalex.org/W2011352354","https://openalex.org/W2013172585","https://openalex.org/W2013253758","https://openalex.org/W2021109810","https://openalex.org/W2033735921","https://openalex.org/W2035966581","https://openalex.org/W2042369211","https://openalex.org/W2051513032","https://openalex.org/W2064045597","https://openalex.org/W2067822815","https://openalex.org/W2085678267","https://openalex.org/W2095256418","https://openalex.org/W2111024858","https://openalex.org/W2124347218","https://openalex.org/W2125831750","https://openalex.org/W2133192278","https://openalex.org/W2145975061","https://openalex.org/W2150914815","https://openalex.org/W2172085921","https://openalex.org/W2333401880","https://openalex.org/W6759237196"],"related_works":["https://openalex.org/W2013253758","https://openalex.org/W2363253983","https://openalex.org/W2921094048","https://openalex.org/W2374448056","https://openalex.org/W2606279989","https://openalex.org/W7096337524","https://openalex.org/W2151069471","https://openalex.org/W1993480900","https://openalex.org/W2518982130","https://openalex.org/W3104542147"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cigarette":[1],"smokers":[2,41],"are":[3,42],"known":[4],"to":[5,71,248,261],"have":[6],"lower":[7],"concentrations":[8,62,107,187],"of":[9,25,40,50,74,79,82,91,211,218,240,254,265],"circulating":[10],"ascorbic":[11,45,60,105,185,213,250,255],"acid":[12,61,106,186,214,256],"than":[13],"nonsmokers.":[14],"In":[15,220],"contrast,":[16],"there":[17],"is":[18,53,68],"evidence":[19],"that":[20],"the":[21,26,37,59,72,92,221,241],"extracellular":[22],"fluid":[23],"lining":[24],"alveolus,":[27],"which":[28],"comes":[29],"in":[30,77,146,194,215],"close":[31],"contact":[32],"with":[33,44,121,163],"cigarette":[34],"smoke,":[35],"and":[36,63,87,94,188,198,243],"alveolar":[38],"macrophages":[39],"enriched":[43],"acid.":[46,251],"The":[47,56,139,181,252],"clinical":[48],"significance":[49],"these":[51,258],"observations":[52],"unknown.":[54],"METHODS:":[55],"authors":[57],"measured":[58],"radiolabeled":[64,140,189],"methyl":[65,141,190],"incorporation":[66,142,191],"(which":[67],"inversely":[69],"related":[70],"degree":[73],"DNA":[75,193],"methylation":[76,217,264],"vivo)":[78],"paired":[80],"samples":[81],"squamous":[83],"cell":[84],"carcinoma":[85],"(SCC)":[86],"adjacent":[88],"uninvolved":[89,124,166,222],"mucosa":[90],"lung":[93,242],"larynx":[95,244],"(n":[96],"=":[97,202,205,233],"22).":[98],"RESULTS:":[99],"Cancerous":[100,238],"tissues":[101,125,148,167,239,259],"had":[102],"significantly":[103,144],"higher":[104,145],"(mean":[108,126,149,168],"+/-":[109,114,127,130,150,153,169,172],"standard":[110],"deviation":[111],"[SD,":[112],"485":[113],"77;":[115],"median,":[116,132,155,174],"483":[117],"ng/mg":[118,134],"protein)":[119],"compared":[120,162],"their":[122,164,246],"matched":[123,165],"SD,":[128,151,170],"151":[129],"52;":[131],"72":[133],"protein;":[135],"P":[136,178,204,235],"<":[137,179],"0.0001).":[138,180],"was":[143,196,226],"cancerous":[147],"31,419":[152],"2629;":[154],"31,416":[156],"counts":[157],"per":[158],"minute":[159],"[CPM]/microg":[160],"DNA)":[161],"11,883":[171],"1567;":[173],"11,444":[175],"CPM/microg":[176],"DNA;":[177],"Spearman":[182],"correlation":[183,225],"between":[184],"by":[192,257],"SCCs":[195],"inverse":[197,227],"statistically":[199,229],"significant":[200,231],"(r":[201,232],"-0.58,":[203],"0.008),":[206],"indicating":[207],"a":[208],"beneficial":[209],"effect":[210],"accumulated":[212],"global":[216,263],"DNA.":[219,266],"tissues,":[223],"this":[224],"but":[228],"not":[230],"-0.20,":[234],"=0.35).":[236],"CONCLUSIONS:":[237],"demonstrated":[245],"ability":[247],"accumulate":[249],"accumulation":[253],"seemed":[260],"facilitate":[262]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
