{"id":"https://openalex.org/W2017581328","doi":"https://doi.org/10.1161/01.cir.48.5.936","title":"Ischemic Response to Sudden Strenuous Exercise in Healthy Men","display_name":"Ischemic Response to Sudden Strenuous Exercise in Healthy Men","publication_year":1973,"publication_date":"1973-11-01","ids":{"openalex":"https://openalex.org/W2017581328","doi":"https://doi.org/10.1161/01.cir.48.5.936","mag":"2017581328","pmid":"https://pubmed.ncbi.nlm.nih.gov/4751958"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.48.5.936","doi":"https://doi.org/10.1161/01.cir.48.5.936","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.48.5.936","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.48.5.936","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.48.5.936","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113595456","display_name":"R. James Barnard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. JAMES BARNARD","raw_affiliation_strings":["From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001547941","display_name":"Rex N. MacAlpin","orcid":"https://orcid.org/0000-0002-8396-1397","observed_orcids":["https://orcid.org/0000-0002-8396-1397"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"REX MACALPIN","raw_affiliation_strings":["From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048543230","display_name":"Albert A. Kattus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ALBERT A. KATTUS","raw_affiliation_strings":["From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112827187","display_name":"Gerald D. Buckberg","orcid":"https://orcid.org/0000-0002-4823-600X","observed_orcids":["https://orcid.org/0000-0002-4823-600X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GERALD D. BUCKBERG","raw_affiliation_strings":["From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":9.4876,"has_fulltext":true,"cited_by_count":129,"citation_normalized_percentile":{"value":0.97051597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"48","issue":"5","first_page":"936","last_page":"942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subendocardial-ischemia","display_name":"subendocardial ischemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/exercise-induced-st-segment-changes","display_name":"exercise-induced ST-segment changes","score":0.6119999885559082},{"id":"https://openalex.org/keywords/tension-time-index","display_name":"tension-time index","score":0.9980000257492065},{"id":"https://openalex.org/keywords/warm-up","display_name":"warm-up","score":0.8180000185966492},{"id":"https://openalex.org/keywords/treadmill-exercise-testing","display_name":"treadmill exercise testing","score":0.7609999775886536},{"id":"https://openalex.org/keywords/intra-arterial-blood-pressure","display_name":"intra-arterial blood pressure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9513754844665527},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7527648210525513},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7383124828338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6158992052078247},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5242493748664856},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.45431777834892273},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4395575225353241},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.41937020421028137},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.41019320487976074}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.48.5.936","doi":"https://doi.org/10.1161/01.cir.48.5.936","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.48.5.936","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.48.5.936","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:4751958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4751958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.cir.48.5.936","doi":"https://doi.org/10.1161/01.cir.48.5.936","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.48.5.936","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.48.5.936","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017581328.pdf","grobid_xml":"https://content.openalex.org/works/W2017581328.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969007702","https://openalex.org/W2026517141","https://openalex.org/W2056532393","https://openalex.org/W2138131313","https://openalex.org/W2146150343","https://openalex.org/W2185500079","https://openalex.org/W2270287237","https://openalex.org/W2286268535","https://openalex.org/W2331786365","https://openalex.org/W2468010284"],"related_works":["https://openalex.org/W2759680657","https://openalex.org/W2415353855","https://openalex.org/W2032601145","https://openalex.org/W2138131313","https://openalex.org/W2102787557","https://openalex.org/W2047359177","https://openalex.org/W2282301416","https://openalex.org/W2030548410","https://openalex.org/W2142653656","https://openalex.org/W2109508048"],"abstract_inverted_index":{"In":[0],"ten":[1],"healthy,":[2],"asymptomatic":[3],"men,":[4],"intra-arterial":[5],"pressure":[6,25,169],"and":[7,29,77,118,132],"electrocardiograms":[8],"were":[9],"recorded":[10],"during":[11],"various":[12],"types":[13],"of":[14,46],"exercise.":[15],"Potential":[16],"subendocardial":[17,150,160],"blood":[18],"flow":[19],"was":[20,58,100,126],"estimated":[21,33],"from":[22,34,167],"a":[23,88,154],"diastolic":[24],"time":[26,37],"index":[27,38],"(DPTI)":[28],"myocardial":[30],"oxygen":[31,161],"requirements":[32],"the":[35,47,56,159],"tension":[36],"(TTI).":[39],"The":[40],"ratio":[41],"DPTI/TTI":[42,57,99,125],"provided":[43],"an":[44],"estimate":[45],"supply/demand":[48,162],"relationship":[49,163],"With":[50,87],"sudden":[51,92,122],"vigorous":[52,143],"exercise":[53,93,144],"without":[54],"warm-up,":[55],"below":[59,68,101],"0.35":[60],"in":[61,70,80,103,129,145,158],"three":[62,71],"men":[63,72,82,147],"who":[64,106],"had":[65,107],"ischemic":[66,96],"electrocardiograms,":[67],"0.44":[69,79,102,128],"with":[73,83],"minor":[74,108],"ST":[75,85,109,134],"abnormalities,":[76],"above":[78,127],"four":[81],"normal":[84,146],"segments.":[86],"prior":[89],"warm-up":[90],"exercise,":[91,123],"caused":[94,152],"no":[95,133],"changes,":[97],"but":[98,124],"two":[104],"subjects":[105],"abnormalities.":[110],"Maximum":[111],"treadmill":[112],"testing":[113],"produced":[114,140],"higher":[115],"heart":[116],"rates":[117],"TTI":[119],"than":[120],"did":[121],"all":[130],"cases":[131],"abnormalities":[135],"occurred.":[136],"Abnormal":[137],"electrocardiographic":[138],"responses":[139],"by":[141,153],"sudden,":[142],"may":[148],"represent":[149],"ischemia":[151],"transient,":[155],"unfavorable":[156],"alteration":[157],"which":[164],"is":[165],"predictable":[166],"arterial":[168],"measurements.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}