{"id":"https://openalex.org/W2017577682","doi":"https://doi.org/10.1159/000312690","title":"Effects of Silibinin, Inhibitor of CYP3A4 and P-Glycoprotein in vitro, on the Pharmacokinetics of Paclitaxel after Oral and Intravenous Administration in Rats","display_name":"Effects of Silibinin, Inhibitor of CYP3A4 and P-Glycoprotein in vitro, on the Pharmacokinetics of Paclitaxel after Oral and Intravenous Administration in Rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2017577682","doi":"https://doi.org/10.1159/000312690","mag":"2017577682","pmid":"https://pubmed.ncbi.nlm.nih.gov/20523105"},"language":"en","primary_location":{"id":"doi:10.1159/000312690","doi":"https://doi.org/10.1159/000312690","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000312690","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029247595","display_name":"Chong\u2010Ki Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198667473","display_name":"Chodang University","ror":"https://ror.org/00yezxw87","country_code":"KR","type":"education","lineage":["https://openalex.org/I198667473"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chong-Ki Lee","raw_affiliation_strings":["Department of Medical Management, Chodang University, Mooan, Republic of Korea","Department of Medical Management, Chodang University, Mooan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Management, Chodang University, Mooan, Republic of Korea","institution_ids":["https://openalex.org/I198667473"]},{"raw_affiliation_string":"Department of Medical Management, Chodang University, Mooan, and","institution_ids":["https://openalex.org/I198667473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113947716","display_name":"Jun\u2010Shik Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun-Shik Choi","raw_affiliation_strings":["College of Pharmacy, Chosun University, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chosun University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I152238500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2733,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.8802859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"85","issue":"6","first_page":"350","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":1.0},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyp3a4-inhibition","display_name":"CYP3A4 inhibition","score":0.968999981880188},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibition","display_name":"P-glycoprotein inhibition","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6980000138282776},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.7760000228881836},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6169999837875366},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2777130413","wikidata":"https://www.wikidata.org/wiki/Q425702","display_name":"Silibinin","level":2,"score":0.9932254552841187},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8871788382530212},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.8205242156982422},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7916651964187622},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.6503677368164062},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6487043499946594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6433406472206116},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5717694163322449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2977883517742157},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.22267606854438782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20854496955871582},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14669644832611084},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.14269700646400452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12620288133621216}],"mesh":[{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D041743","descriptor_name":"Herb-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000312690","doi":"https://doi.org/10.1159/000312690","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000312690","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:20523105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20523105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W176809139","https://openalex.org/W1816481860","https://openalex.org/W1841167187","https://openalex.org/W1847959577","https://openalex.org/W1964909448","https://openalex.org/W1965002318","https://openalex.org/W1967829206","https://openalex.org/W1975872727","https://openalex.org/W1976771657","https://openalex.org/W1977542664","https://openalex.org/W1979214808","https://openalex.org/W1984820569","https://openalex.org/W2002884027","https://openalex.org/W2007788734","https://openalex.org/W2009649574","https://openalex.org/W2020363833","https://openalex.org/W2036889312","https://openalex.org/W2044102044","https://openalex.org/W2076269997","https://openalex.org/W2085815144","https://openalex.org/W2092357016","https://openalex.org/W2110663500","https://openalex.org/W2121019104","https://openalex.org/W2133536147","https://openalex.org/W2135538021","https://openalex.org/W2144111899","https://openalex.org/W2144868623","https://openalex.org/W2153138245","https://openalex.org/W2154105843","https://openalex.org/W2169427225","https://openalex.org/W2213012239","https://openalex.org/W2223026985","https://openalex.org/W2308532732","https://openalex.org/W2320969323","https://openalex.org/W2417478787"],"related_works":["https://openalex.org/W1993426734","https://openalex.org/W2394917489","https://openalex.org/W2072900165","https://openalex.org/W2068442128","https://openalex.org/W3091922327","https://openalex.org/W2352658800","https://openalex.org/W1969583688","https://openalex.org/W3026833445","https://openalex.org/W1979214808","https://openalex.org/W2909244384"],"abstract_inverted_index":{"Silibinin,":[0],"a":[1],"flavonoid,":[2],"is":[3,15],"an":[4,96],"inhibitor":[5],"of":[6,21,29,37,48,68,77,98,137,164,170,187,198,207,215,225,236],"P-glycoprotein":[7],"(P-gp)-mediated":[8],"efflux":[9],"transporters,":[10],"and":[11,35,39,66,183],"its":[12],"oxidative":[13],"metabolism":[14],"catalyzed":[16],"by":[17,118,124,147,155,174,203],"CYP3A4.":[18],"The":[19,45,75,195],"purpose":[20],"this":[22],"study":[23],"was":[24,87,172,190],"to":[25,109,177,193,211,231],"investigate":[26],"the":[27,33,64,80,110,128,131,160,167,180,184,204,212,218,223,232],"effect":[28,76],"oral":[30,55,138,188,213,220],"silibinin":[31,69,78,103,113,175,208,226],"on":[32,79],"bioavailability":[34,169,186,221],"pharmacokinetics":[36,197],"orally":[38],"intravenously":[40],"administered":[41],"paclitaxel":[42,49,171,189,199,237],"in":[43,52,63,179,209,222],"rats.":[44],"pharmacokinetic":[46],"parameters":[47],"were":[50,200],"determined":[51],"rats":[53],"after":[54],"(40":[56],"mg/kg)":[57,61,126],"or":[58,72],"intravenous":[59,196],"(4":[60],"administration":[62,214],"presence":[65,224],"absence":[67],"(0.5,":[70],"2.5":[71,119,148],"10":[73,125,156],"mg/kg).":[74],"P-gp":[81,106,239],"as":[82,84],"well":[83],"CYP3A4":[85,92],"activity":[86,94],"also":[88,141],"evaluated.":[89],"Silibinin":[90,140],"inhibited":[91,105],"enzyme":[93],"with":[95],"IC(50)":[97],"1.8":[99],"mumol/l.":[100],"In":[101],"addition,":[102],"significantly":[104,114,142],"activity.":[107],"Compared":[108],"control":[111,181],"group,":[112,182],"(p":[115,144],"<":[116,122,145,153],"0.05":[117,146],"mg/kg,":[120,149,157],"p":[121,152],"0.01":[123,154],"increased":[127,143,173,191,233],"area":[129],"under":[130],"plasma":[132,162],"concentration-time":[133],"curve":[134],"(65.8-101.7%":[135],"higher)":[136,159],"paclitaxel.":[139,165,216],"31.0%":[150],"higher;":[151],"52.9%":[158],"peak":[161],"concentration":[163],"Consequently,":[166],"absolute":[168],"compared":[176],"that":[178],"relative":[185],"1.15-":[192],"2.02-fold.":[194],"not":[201],"affected":[202],"concurrent":[205],"use":[206],"contrast":[210],"Accordingly,":[217],"enhanced":[219],"could":[227],"mainly":[228],"be":[229],"due":[230],"intestinal":[234],"absorption":[235],"via":[238],"inhibition.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}