{"id":"https://openalex.org/W2017576770","doi":"https://doi.org/10.2147/blctt.s15565","title":"Reduced intensity treatment in early-stage Hodgkin\u2019s lymphoma","display_name":"Reduced intensity treatment in early-stage Hodgkin\u2019s lymphoma","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2017576770","doi":"https://doi.org/10.2147/blctt.s15565","mag":"2017576770"},"language":"en","primary_location":{"id":"doi:10.2147/blctt.s15565","doi":"https://doi.org/10.2147/blctt.s15565","is_oa":true,"landing_page_url":"https://doi.org/10.2147/blctt.s15565","pdf_url":"https://www.dovepress.com/getfile.php?fileID=11466","source":{"id":"https://openalex.org/S4210230819","display_name":"Blood and Lymphatic Cancer Targets and Therapy","issn_l":"1179-9889","issn":["1179-9889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood and Lymphatic Cancer: Targets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=11466","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086492517","display_name":"Prathima Prodduturi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prathima Prodduturi","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112264084","display_name":"Armitage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Armitage","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086492517","https://openalex.org/A5112264084"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.2901,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60357143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-stage-hodgkin-s-lymphoma","display_name":"early-stage Hodgkin's lymphoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/abvd","display_name":"ABVD chemotherapy","score":0.6330000162124634},{"id":"https://openalex.org/keywords/mopp-chemotherapy","display_name":"MOPP chemotherapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/involved-field-radiotherapy","display_name":"involved-field radiotherapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/extended-field-radiotherapy","display_name":"extended field radiotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.7620000243186951},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.4099999964237213},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.7590000033378601},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.574999988079071},{"id":"https://openalex.org/keywords/interim-pet","display_name":"interim PET","score":0.6150000095367432},{"id":"https://openalex.org/keywords/treatment-de-escalation","display_name":"treatment de-escalation","score":0.652999997138977},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2776305933","wikidata":"https://www.wikidata.org/wiki/Q287631","display_name":"ABVD","level":5,"score":0.8961287140846252},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.8528938293457031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8099265098571777},{"id":"https://openalex.org/C2779112685","wikidata":"https://www.wikidata.org/wiki/Q418656","display_name":"Procarbazine","level":5,"score":0.7479889392852783},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6378068327903748},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.6160625219345093},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5840633511543274},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5384246110916138},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5132248401641846},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4962683320045471},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.4467947781085968},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4279055893421173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4048346281051636},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2139352262020111},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/blctt.s15565","doi":"https://doi.org/10.2147/blctt.s15565","is_oa":true,"landing_page_url":"https://doi.org/10.2147/blctt.s15565","pdf_url":"https://www.dovepress.com/getfile.php?fileID=11466","source":{"id":"https://openalex.org/S4210230819","display_name":"Blood and Lymphatic Cancer Targets and Therapy","issn_l":"1179-9889","issn":["1179-9889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood and Lymphatic Cancer: Targets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:dovepress.com/8737","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/reduced-intensity-treatment-in-early-stage-hodgkinrsquos-lymphoma-peer-reviewed-article-BLCTT","pdf_url":"https://www.dovepress.com/reduced-intensity-treatment-in-early-stage-hodgkinrsquos-lymphoma-peer-reviewed-article-BLCTT","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"},{"id":"pmh:oai:doaj.org/article:c4f4e07d307e47caa9d5db84f40d0989","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c4f4e07d307e47caa9d5db84f40d0989","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood and Lymphatic Cancer: Targets and Therapy, Vol 2011, Iss default, Pp 23-31 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/blctt.s15565","doi":"https://doi.org/10.2147/blctt.s15565","is_oa":true,"landing_page_url":"https://doi.org/10.2147/blctt.s15565","pdf_url":"https://www.dovepress.com/getfile.php?fileID=11466","source":{"id":"https://openalex.org/S4210230819","display_name":"Blood and Lymphatic Cancer Targets and Therapy","issn_l":"1179-9889","issn":["1179-9889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood and Lymphatic Cancer: Targets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017576770.pdf","grobid_xml":"https://content.openalex.org/works/W2017576770.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W62513340","https://openalex.org/W160032427","https://openalex.org/W1801161035","https://openalex.org/W1823415135","https://openalex.org/W1829707378","https://openalex.org/W1833833181","https://openalex.org/W1873070501","https://openalex.org/W1883598689","https://openalex.org/W1890322031","https://openalex.org/W1917085797","https://openalex.org/W1932121194","https://openalex.org/W1963728751","https://openalex.org/W1964918642","https://openalex.org/W1966947896","https://openalex.org/W1999130958","https://openalex.org/W2005849078","https://openalex.org/W2018925169","https://openalex.org/W2021906502","https://openalex.org/W2024136031","https://openalex.org/W2024291302","https://openalex.org/W2025318905","https://openalex.org/W2026863359","https://openalex.org/W2058578880","https://openalex.org/W2068426057","https://openalex.org/W2074858519","https://openalex.org/W2090762862","https://openalex.org/W2092389377","https://openalex.org/W2097549973","https://openalex.org/W2098179714","https://openalex.org/W2104221398","https://openalex.org/W2105259666","https://openalex.org/W2105900079","https://openalex.org/W2106193652","https://openalex.org/W2107800684","https://openalex.org/W2111629056","https://openalex.org/W2115362683","https://openalex.org/W2118875599","https://openalex.org/W2120797612","https://openalex.org/W2121605135","https://openalex.org/W2130095179","https://openalex.org/W2136761623","https://openalex.org/W2137965731","https://openalex.org/W2140801657","https://openalex.org/W2142478330","https://openalex.org/W2148820011","https://openalex.org/W2155638921","https://openalex.org/W2155990600","https://openalex.org/W2157380118","https://openalex.org/W2161896689","https://openalex.org/W2162848902","https://openalex.org/W2163693301","https://openalex.org/W2163695063","https://openalex.org/W2170916275","https://openalex.org/W2176758680","https://openalex.org/W2222626684","https://openalex.org/W2243890309","https://openalex.org/W2252303868","https://openalex.org/W2266633670","https://openalex.org/W2269404396","https://openalex.org/W2341591060","https://openalex.org/W2573608719","https://openalex.org/W3016556272","https://openalex.org/W4235573797","https://openalex.org/W4251780360","https://openalex.org/W4253996209","https://openalex.org/W6816612651"],"related_works":["https://openalex.org/W2140801657","https://openalex.org/W2057651026","https://openalex.org/W2000908846","https://openalex.org/W2902271248","https://openalex.org/W2258525901","https://openalex.org/W2321808656","https://openalex.org/W2558777417","https://openalex.org/W3021183895","https://openalex.org/W2059677602","https://openalex.org/W4243480015"],"abstract_inverted_index":{"Abstract:":[0],"Early-stage":[1],"Hodgkin\u2019s":[2,46,66,208,227],"lymphoma":[3,47,67,209],"which":[4],"includes":[5],"patients":[6,43,189],"with":[7,44,155],"Ann":[8],"Arbor":[9],"stages":[10],"I":[11],"or":[12],"II,":[13],"accounts":[14],"for":[15],"more":[16,115],"than":[17,116],"50%":[18],"of":[19,22,32,108,142,167,177,201,214],"all":[20],"cases":[21],"the":[23,39,60,62,109,120,124,140,150,202,215],"illness":[24],"and":[25,56,95,137,144,210],"is":[26,48,100],"curable":[27],"in":[28,41,65,187,206,222],"a":[29],"high":[30,154],"proportion":[31],"patients.":[33],"Long-term":[34],"follow-up":[35],"has":[36,68,146],"shown":[37],"that":[38,106],"mortality":[40,232],"favorable-risk":[42],"early-stage":[45,207,223],"exceeded":[49],"by":[50],"other":[51],"causes":[52],"including":[53],"secondary":[54,110],"malignancies":[55,111],"cardiac":[57],"disease.":[58],"Over":[59],"decades":[61],"treatment":[63,221],"paradigm":[64],"evolved":[69],"from":[70,91,127],"extended":[71],"field":[72,80,97],"radiotherapy":[73,81],"to":[74,82,133,182],"combined":[75],"modality":[76],"therapy":[77,99,186],"using":[78,83,92,162],"involved":[79],"chemotherapy":[84,125,163,178],"alone.":[85,164],"The":[86,165],"data":[87],"on":[88,161,212],"long-term":[89],"complications":[90],"low":[93],"dose":[94],"limited":[96],"radiation":[98],"still":[101,191],"awaited":[102],"since":[103],"we":[104,197],"know":[105],"most":[107],"occur":[112],"late":[113,151],"(ie,":[114],"10":[117],"years":[118],"after":[119,174],"treatment).":[121],"By":[122],"changing":[123],"regimens":[126],"mechlorethamine,":[128],"vincristine,":[129],"procarbazine,":[130],"prednisone":[131],"(MOPP)":[132],"doxorubicin,":[134],"bleomycin,":[135],"vinblastine,":[136],"dacarbazine":[138],"(ABVD)":[139],"incidence":[141],"infertility":[143],"leukemia":[145],"been":[147],"reduced.":[148],"Since":[149],"toxicity":[152],"was":[153],"radiotherapy,":[156],"recent":[157,216],"studies":[158],"have":[159,198],"focused":[160],"results":[166],"interim":[168],"positron":[169],"emission":[170],"tomography":[171],"(PET)":[172],"scans":[173],"two":[175],"cycles":[176],"are":[179],"being":[180],"tested":[181],"see":[183],"whether":[184],"minimizing":[185],"rapidly-responding":[188],"will":[190],"maintain":[192],"excellent":[193],"cure":[194],"rates.":[195],"Here,":[196],"reviewed":[199],"some":[200,213],"important":[203],"clinical":[204],"trials":[205,217],"focus":[211],"emphasizing":[218],"reduced":[219],"intensity":[220],"Hodgkin's":[224],"lymphoma.":[225],"Keywords:":[226],"lymphoma,":[228],"treatment,":[229],"early-stage,":[230],"intensity,":[231]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}