{"id":"https://openalex.org/W2017575868","doi":"https://doi.org/10.1038/newbio245014a0","title":"Thymus-dependent Functions of Mouse Thymocyte-Fibroblast Hybrid Cells","display_name":"Thymus-dependent Functions of Mouse Thymocyte-Fibroblast Hybrid Cells","publication_year":1973,"publication_date":"1973-09-01","ids":{"openalex":"https://openalex.org/W2017575868","doi":"https://doi.org/10.1038/newbio245014a0","mag":"2017575868","pmid":"https://pubmed.ncbi.nlm.nih.gov/4147009"},"language":"en","primary_location":{"id":"doi:10.1038/newbio245014a0","doi":"https://doi.org/10.1038/newbio245014a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/newbio245014a0","pdf_url":null,"source":{"id":"https://openalex.org/S4210210546","display_name":"Nature New Biology","issn_l":"0090-0028","issn":["0090-0028","2058-1092"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature New Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045306382","display_name":"Robertson Parkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERTSON PARKMAN","raw_affiliation_strings":["Immunology Division, Department of Medicine, Children's Hospital Medical Center, and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115","Immunology Division, Department of Medicine, Children's Hospital Medical Center and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Division, Department of Medicine, Children's Hospital Medical Center, and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Immunology Division, Department of Medicine, Children's Hospital Medical Center and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007972136","display_name":"Ezio Merler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EZIO MERLER","raw_affiliation_strings":["Immunology Division, Department of Medicine, Children's Hospital Medical Center, and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115","Immunology Division, Department of Medicine, Children's Hospital Medical Center and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Division, Department of Medicine, Children's Hospital Medical Center, and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Immunology Division, Department of Medicine, Children's Hospital Medical Center and the Departments of Pediatrics and Microbiology and Molecular Genetics, Harvard Medical School, Boston,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.3473,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56696365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"245","issue":"140","first_page":"14","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.8059999942779541},{"id":"https://openalex.org/keywords/t-cell-heterogeneity","display_name":"T cell heterogeneity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/t-cell-culture","display_name":"T cell culture","score":0.37700000405311584},{"id":"https://openalex.org/keywords/antibody-producing-cells","display_name":"antibody-forming cells","score":0.5960000157356262},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5720000267028809},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.7027408480644226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6367722749710083},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5643083453178406},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5347110033035278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5263584852218628},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5259292721748352},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5214871168136597},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49836254119873047},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.48790380358695984},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4354114830493927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4257253110408783},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4154411554336548},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4133709967136383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36412328481674194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0809856653213501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06998676061630249},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006087","descriptor_name":"Graft vs Host Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007104","descriptor_name":"Immune Adherence Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010222","descriptor_name":"Parainfluenza Virus 1, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010527","descriptor_name":"Perissodactyla","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011828","descriptor_name":"Radiation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/newbio245014a0","doi":"https://doi.org/10.1038/newbio245014a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/newbio245014a0","pdf_url":null,"source":{"id":"https://openalex.org/S4210210546","display_name":"Nature New Biology","issn_l":"0090-0028","issn":["0090-0028","2058-1092"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature New Biology","raw_type":"journal-article"},{"id":"pmid:4147009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4147009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature: New biology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1973-2698","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1973/1699","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1973","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1502226870","https://openalex.org/W1966804037","https://openalex.org/W1968373623","https://openalex.org/W1972030215","https://openalex.org/W1972232380","https://openalex.org/W1997986503","https://openalex.org/W2052789843","https://openalex.org/W2055800996","https://openalex.org/W2064952399","https://openalex.org/W2080897471","https://openalex.org/W2082588999","https://openalex.org/W2114258661","https://openalex.org/W2148925388","https://openalex.org/W2470931210","https://openalex.org/W2924065312","https://openalex.org/W3156747898","https://openalex.org/W4213122016"],"related_works":["https://openalex.org/W7097717436","https://openalex.org/W1100404433","https://openalex.org/W14724135","https://openalex.org/W2482609494","https://openalex.org/W7099261055","https://openalex.org/W346381096","https://openalex.org/W82724760","https://openalex.org/W70508599","https://openalex.org/W2075196328","https://openalex.org/W796277120"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}