{"id":"https://openalex.org/W2017572122","doi":"https://doi.org/10.1007/s007020200061","title":"Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy","display_name":"Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2017572122","doi":"https://doi.org/10.1007/s007020200061","mag":"2017572122","pmid":"https://pubmed.ncbi.nlm.nih.gov/12111464"},"language":"en","primary_location":{"id":"doi:10.1007/s007020200061","doi":"https://doi.org/10.1007/s007020200061","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s007020200061","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110095004","display_name":"T Nagatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4405287432","display_name":"Center for Medical Science, Fujita Health University","ror":"https://ror.org/054he0258","country_code":"JP","type":"facility","lineage":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T. Nagatsu","raw_affiliation_strings":["Institute for Comprehensive Medical Science, Graduate School of Medicine, Fujita Health University, Toyoake, Aichi, Japan. tnagatsu@fujita-hu.ac.jp","Institute for Comprehensive Medical Science, Graduate School of Medicine, Fujita Health University Toyoake, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Comprehensive Medical Science, Graduate School of Medicine, Fujita Health University, Toyoake, Aichi, Japan. tnagatsu@fujita-hu.ac.jp","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]},{"raw_affiliation_string":"Institute for Comprehensive Medical Science, Graduate School of Medicine, Fujita Health University Toyoake, Aichi, Japan","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110095004"],"corresponding_institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":5.6452,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.96204255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"109","issue":"5-6","first_page":"731","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nigrostriatal-dopaminergic-neurons","display_name":"nigrostriatal dopaminergic neurons","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7549999952316284},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dopamine-deficiency","display_name":"dopamine deficiency","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mptp-induced-parkinsonism","display_name":"MPTP-induced parkinsonism","score":0.8140000104904175},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.7590000033378601},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.8119999766349792},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8886538743972778},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.8592938184738159},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7183988094329834},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.6640504598617554},{"id":"https://openalex.org/C2776355744","wikidata":"https://www.wikidata.org/wiki/Q4318555","display_name":"Nigrostriatal pathway","level":5,"score":0.659558892250061},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6023122072219849},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5910583734512329},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5101204514503479},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5006749629974365},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4889048635959625},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4884020686149597},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4846837818622589},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4758950471878052},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4335814118385315},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4197232127189636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3785261809825897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36840304732322693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3533111810684204},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22584950923919678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08755925297737122},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08356636762619019}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s007020200061","doi":"https://doi.org/10.1007/s007020200061","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s007020200061","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},{"id":"pmid:12111464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12111464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission (Vienna, Austria : 1996)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W17149418","https://openalex.org/W32913599","https://openalex.org/W1495696399","https://openalex.org/W1497101460","https://openalex.org/W1497427077","https://openalex.org/W1504584187","https://openalex.org/W1525182477","https://openalex.org/W1544063520","https://openalex.org/W1550393765","https://openalex.org/W1597066001","https://openalex.org/W1718365317","https://openalex.org/W1877873625","https://openalex.org/W1881391557","https://openalex.org/W1966918485","https://openalex.org/W1971258758","https://openalex.org/W1973227020","https://openalex.org/W1974924674","https://openalex.org/W1975336660","https://openalex.org/W1977604451","https://openalex.org/W1977707442","https://openalex.org/W1981219971","https://openalex.org/W1984338631","https://openalex.org/W1988463041","https://openalex.org/W1989987745","https://openalex.org/W1991804565","https://openalex.org/W1993168712","https://openalex.org/W1994138059","https://openalex.org/W1994548914","https://openalex.org/W1997208169","https://openalex.org/W1997326200","https://openalex.org/W2000942652","https://openalex.org/W2002503549","https://openalex.org/W2006239462","https://openalex.org/W2006513044","https://openalex.org/W2011777296","https://openalex.org/W2013700933","https://openalex.org/W2015290074","https://openalex.org/W2024917983","https://openalex.org/W2033985997","https://openalex.org/W2037473273","https://openalex.org/W2039631987","https://openalex.org/W2040096338","https://openalex.org/W2040558323","https://openalex.org/W2041466047","https://openalex.org/W2044345769","https://openalex.org/W2046316938","https://openalex.org/W2051070266","https://openalex.org/W2054397023","https://openalex.org/W2060449537","https://openalex.org/W2062583723","https://openalex.org/W2062598259","https://openalex.org/W2067340670","https://openalex.org/W2076344205","https://openalex.org/W2082861241","https://openalex.org/W2090930997","https://openalex.org/W2092553981","https://openalex.org/W2093012444","https://openalex.org/W2104965614","https://openalex.org/W2107658086","https://openalex.org/W2108724455","https://openalex.org/W2115818366","https://openalex.org/W2127697359","https://openalex.org/W2137829901","https://openalex.org/W2142780460","https://openalex.org/W2150656456","https://openalex.org/W2154278641","https://openalex.org/W2158064024","https://openalex.org/W2162979967","https://openalex.org/W2164314374","https://openalex.org/W2177094286","https://openalex.org/W2189595531","https://openalex.org/W2325263169","https://openalex.org/W2339865699","https://openalex.org/W2395026840","https://openalex.org/W2413861651","https://openalex.org/W2525550930"],"related_works":["https://openalex.org/W17149418","https://openalex.org/W2127697359","https://openalex.org/W41595645","https://openalex.org/W2374710698","https://openalex.org/W2434514040","https://openalex.org/W2047516655","https://openalex.org/W1972908392","https://openalex.org/W844984112","https://openalex.org/W1478126104","https://openalex.org/W2575566424"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}