{"id":"https://openalex.org/W2017568818","doi":"https://doi.org/10.3892/or.14.2.441","title":"Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells","display_name":"Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2017568818","doi":"https://doi.org/10.3892/or.14.2.441","mag":"2017568818","pmid":"https://pubmed.ncbi.nlm.nih.gov/16012728"},"language":"en","primary_location":{"id":"doi:10.3892/or.14.2.441","doi":"https://doi.org/10.3892/or.14.2.441","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.14.2.441","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110015560","display_name":"Takahisa Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Shimizu","raw_affiliation_strings":["Department of Hygiene-chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki Noda-shi, Chiba 278-8510, Japan. takahisa@rs.noda.tus.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki Noda-shi, Chiba 278-8510, Japan. takahisa@rs.noda.tus.ac.jp","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102275303","display_name":"Akiko Okayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Okayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084727295","display_name":"Toshihiro Inoue","orcid":"https://orcid.org/0000-0003-3769-7609","observed_orcids":["https://orcid.org/0000-0003-3769-7609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihiro Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055554576","display_name":"Ken Takeda","orcid":"https://orcid.org/0000-0002-2906-5575","observed_orcids":["https://orcid.org/0000-0002-2906-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Takeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3475,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59458533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"2","first_page":"441","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":1.0},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ccn1","display_name":"CYR61","score":0.9679999947547913},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.6809999942779541},{"id":"https://openalex.org/keywords/g2-m-transition","display_name":"G2/M transition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.8027374148368835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7439064979553223},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5362638235092163},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49828481674194336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48041701316833496},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4736382067203522},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4634113013744354},{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.4564715325832367},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4393536150455475},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4004221558570862},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39095669984817505},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3874884247779846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37382960319519043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2079545259475708},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17770466208457947},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.05069094896316528},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.14.2.441","doi":"https://doi.org/10.3892/or.14.2.441","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.14.2.441","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:16012728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16012728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028618614","https://openalex.org/W1980953174","https://openalex.org/W7097737039","https://openalex.org/W2082463232","https://openalex.org/W2501987856","https://openalex.org/W2082010137","https://openalex.org/W2076611205","https://openalex.org/W1955008898","https://openalex.org/W2013612743","https://openalex.org/W1964584866"],"abstract_inverted_index":{"Staurosporine":[0],"induces":[1],"neuronal":[2,18,113,142],"differentiation":[3,19,143],"and":[4,20,43,85,97,102,144,150,157],"suppresses":[5],"malignancy":[6,147],"of":[7,22,52,73,87,91,107,131,134,146,159],"human":[8],"prostate":[9,160],"cancer":[10],"TSU-Pr1":[11,34,45,127],"cells.":[12,128],"To":[13],"investigate":[14],"the":[15,118,132,139,155],"mechanism":[16],"underlying":[17,141],"suppression":[21],"malignancy,":[23,98],"we":[24,121],"used":[25],"cDNA":[26],"microarrays":[27,50],"to":[28,49],"examine":[29],"gene":[30,58],"expression":[31,59,90],"profiles":[32],"in":[33,57,70,112,126],"cells":[35,46],"treated":[36],"with":[37,94],"staurosporine.":[38],"mRNAs":[39],"isolated":[40],"from":[41],"untreated":[42],"staurosporine-treated":[44],"were":[47,60,68],"hybridised":[48],"consisting":[51],"approximately":[53],"9100":[54],"genes.":[55],"Changes":[56],"verified":[61],"by":[62,148],"Northern":[63],"blot":[64],"analysis.":[65],"Staurosporine-responsive":[66],"genes":[67,92,125,136],"involved":[69,111],"a":[71],"variety":[72],"cellular":[74],"functions":[75],"including":[76],"growth":[77],"regulation,":[78],"differentiation,":[79,114],"replication,":[80],"DNA":[81],"repair,":[82],"G2/M":[83],"transition":[84],"inhibition":[86,145],"apoptosis.":[88],"Interestingly,":[89],"associated":[93],"cell":[95],"proliferation":[96],"such":[99],"as":[100],"Cyr61":[101],"CTGF,":[103],"was":[104,115],"reduced.":[105],"Expression":[106],"CD73/NT5E,":[108],"which":[109],"is":[110],"increased.":[116],"In":[117],"present":[119],"study,":[120],"identified":[122],"various":[123],"staurosporine-responsive":[124],"Further":[129],"studies":[130],"roles":[133],"these":[135],"may":[137],"clarify":[138],"mechanisms":[140],"staurosporine":[149],"identify":[151],"better":[152],"approaches":[153],"for":[154],"prevention":[156],"treatment":[158],"cancer.":[161]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}