{"id":"https://openalex.org/W2017560016","doi":"https://doi.org/10.1002/nbm.1055","title":"Single\u2010voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus","display_name":"Single\u2010voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2017560016","doi":"https://doi.org/10.1002/nbm.1055","mag":"2017560016","pmid":"https://pubmed.ncbi.nlm.nih.gov/16763968"},"language":"en","primary_location":{"id":"doi:10.1002/nbm.1055","doi":"https://doi.org/10.1002/nbm.1055","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nbm.1055","pdf_url":null,"source":{"id":"https://openalex.org/S45012897","display_name":"NMR in Biomedicine","issn_l":"0952-3480","issn":["0952-3480","1099-1492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080521780","display_name":"Talaignair N. Venkatraman","orcid":"https://orcid.org/0000-0002-8565-7604","observed_orcids":["https://orcid.org/0000-0002-8565-7604"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talaignair N. Venkatraman","raw_affiliation_strings":["Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031075094","display_name":"Robert M. Hamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hamer","raw_affiliation_strings":["Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7160","Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7160","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005838731","display_name":"Diana O. Perkins","orcid":"https://orcid.org/0000-0001-9396-2206","observed_orcids":["https://orcid.org/0000-0001-9396-2206"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana O. Perkins","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047732669","display_name":"Allen W. Song","orcid":"https://orcid.org/0000-0003-0308-7941","observed_orcids":["https://orcid.org/0000-0003-0308-7941"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen W. Song","raw_affiliation_strings":["Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Lieberman","raw_affiliation_strings":["Department of Psychiatry, Columbia University, New York, NY 10032 USA","Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, New York, NY 10032 USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035415332","display_name":"R. Grant Steen","orcid":"https://orcid.org/0000-0003-3386-6575","observed_orcids":["https://orcid.org/0000-0003-3386-6575"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Grant Steen","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035415332"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":1.6122,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8219984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"19","issue":"4","first_page":"484","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/press","display_name":"press","score":0.6460000276565552},{"id":"https://openalex.org/keywords/measurement-precision","display_name":"measurement precision","score":0.8740000128746033},{"id":"https://openalex.org/keywords/coefficient-of-variation","display_name":"coefficient of variation","score":0.765999972820282},{"id":"https://openalex.org/keywords/biological-variation","display_name":"biological variation","score":0.6110000014305115},{"id":"https://openalex.org/keywords/n-acetylaspartate","display_name":"N-acetylaspartate","score":0.8769999742507935},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.8619999885559082},{"id":"https://openalex.org/keywords/creatine","display_name":"creatine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.5740000009536743},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7722150683403015},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.6530570983886719},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6453659534454346},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.5732302665710449},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.543799877166748},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4440898597240448},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.4289209842681885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3706552982330322},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31627336144447327},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31624799966812134},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2775663137435913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26590558886528015},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.14856237173080444},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14537984132766724},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1085985004901886},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10469573736190796}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/nbm.1055","doi":"https://doi.org/10.1002/nbm.1055","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nbm.1055","pdf_url":null,"source":{"id":"https://openalex.org/S45012897","display_name":"NMR in Biomedicine","issn_l":"0952-3480","issn":["0952-3480","1099-1492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in Biomedicine","raw_type":"journal-article"},{"id":"pmid:16763968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16763968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in biomedicine","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1164959577","display_name":null,"funder_award_id":"MH-64065","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1741253382","display_name":"BRAIN MRI &MRS CHANGES IN FIRST EPISODE SCHIZOPHRENIA","funder_award_id":"R01MH061603","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3834498211","display_name":"Prospective Studies of the Pathogenesis of Schizophrenia","funder_award_id":"P50MH064065","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4482049921","display_name":null,"funder_award_id":"MH 61603","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1965782412","https://openalex.org/W1969693622","https://openalex.org/W1975822811","https://openalex.org/W1989464795","https://openalex.org/W2001399554","https://openalex.org/W2002097283","https://openalex.org/W2004979681","https://openalex.org/W2018472681","https://openalex.org/W2023639782","https://openalex.org/W2025133542","https://openalex.org/W2035144534","https://openalex.org/W2038979894","https://openalex.org/W2042140307","https://openalex.org/W2047229542","https://openalex.org/W2051821447","https://openalex.org/W2064869376","https://openalex.org/W2065653189","https://openalex.org/W2066335839","https://openalex.org/W2083589763","https://openalex.org/W2084111672","https://openalex.org/W2084689734","https://openalex.org/W2088342663","https://openalex.org/W2104150998","https://openalex.org/W2104500090","https://openalex.org/W2106080976","https://openalex.org/W2125793940","https://openalex.org/W2158514967","https://openalex.org/W2161044358"],"related_works":["https://openalex.org/W2007392325","https://openalex.org/W1989464795","https://openalex.org/W2066335839","https://openalex.org/W2023639782","https://openalex.org/W2084111672","https://openalex.org/W2047229542","https://openalex.org/W2052065888","https://openalex.org/W2146698818","https://openalex.org/W2624861738","https://openalex.org/W1909972692"],"abstract_inverted_index":{"The":[0],"precision":[1,52],"[coefficient":[2],"of":[3,10,65],"variation":[4],"or":[5],"CV":[6,64],"(%)":[7],"=":[8],"100SD/X]":[9],"single-voxel":[11],"point":[12],"resolved":[13],"spectroscopic":[14],"data":[15],"was":[16,34],"characterized":[17],"bilaterally,":[18],"in":[19,23,28,55,59,73,78,87,92,103,107,126],"anterior":[20,56,74],"cingulate":[21,57,75],"and":[22,41,71,76,91,130],"hippocampus,":[24,60],"at":[25],"4.0":[26],"T":[27],"a":[29,123],"healthy":[30,89,108],"subject.":[31],"Data":[32],"acquisition":[33],"replicated":[35],"10":[36],"times":[37],"after":[38],"voxel":[39],"repositioning":[40],"readjusting":[42],"higher":[43],"order":[44],"shims.":[45],"Precision":[46],"measurements":[47,81],"show":[48],"that":[49,97,113],"the":[50,84],"scan-to-scan":[51],"is":[53,99],"better":[54],"than":[58,115],"with":[61],"an":[62],"average":[63],"9.2%":[66],"(for":[67],"total":[68],"NAA,":[69],"tCho":[70],"Cr)":[72],"13.9%":[77],"hippocampus.":[79],"Variability":[80],"made":[82],"by":[83],"same":[85],"method":[86],"24":[88],"subjects":[90,117],"29":[93],"schizophrenia":[94],"patients":[95,129],"showed":[96],"there":[98],"substantial":[100],"biological":[101],"variability":[102],"metabolite":[104],"levels,":[105],"even":[106],"subjects.":[109],"Simple":[110],"calculations":[111],"suggest":[112],"more":[114],"200":[116],"would":[118],"be":[119],"needed":[120],"to":[121],"detect":[122],"5%":[124],"difference":[125],"NAA":[127],"between":[128],"controls.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}