{"id":"https://openalex.org/W2017550829","doi":"https://doi.org/10.1074/jbc.274.33.23223","title":"Aqueous Dissolution of Alzheimer's Disease A\u03b2 Amyloid Deposits by Biometal Depletion","display_name":"Aqueous Dissolution of Alzheimer's Disease A\u03b2 Amyloid Deposits by Biometal Depletion","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2017550829","doi":"https://doi.org/10.1074/jbc.274.33.23223","mag":"2017550829","pmid":"https://pubmed.ncbi.nlm.nih.gov/10438495"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.33.23223","doi":"https://doi.org/10.1074/jbc.274.33.23223","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.33.23223","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.274.33.23223","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033772486","display_name":"Robert A. Cherny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139829854","display_name":"Mental Health Research Institute","ror":"https://ror.org/041684t28","country_code":"AU","type":"facility","lineage":["https://openalex.org/I139829854","https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert A. Cherny","raw_affiliation_strings":["Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I139829854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036044148","display_name":"Jacinta T. Legg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139829854","display_name":"Mental Health Research Institute","ror":"https://ror.org/041684t28","country_code":"AU","type":"facility","lineage":["https://openalex.org/I139829854","https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacinta T. Legg","raw_affiliation_strings":["Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I139829854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054461576","display_name":"Catriona McLean","orcid":"https://orcid.org/0000-0002-0302-5727","observed_orcids":["https://orcid.org/0000-0002-0302-5727"]},"institutions":[{"id":"https://openalex.org/I139829854","display_name":"Mental Health Research Institute","ror":"https://ror.org/041684t28","country_code":"AU","type":"facility","lineage":["https://openalex.org/I139829854","https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catriona A. McLean","raw_affiliation_strings":["Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I139829854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053439487","display_name":"David P. Fairlie","orcid":"https://orcid.org/0000-0002-7856-8566","observed_orcids":["https://orcid.org/0000-0002-7856-8566"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David P. Fairlie","raw_affiliation_strings":["Centre for Drug Design and Development, University of Queensland, Brisbane 4072, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Drug Design and Development, University of Queensland, Brisbane 4072, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080825168","display_name":"Xudong Huang","orcid":"https://orcid.org/0000-0002-4811-1901","observed_orcids":["https://orcid.org/0000-0002-4811-1901"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xudong Huang","raw_affiliation_strings":["Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067709976","display_name":"Craig Atwood","orcid":"https://orcid.org/0000-0001-5040-1679","observed_orcids":["https://orcid.org/0000-0001-5040-1679"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig S. Atwood","raw_affiliation_strings":["Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112198503","display_name":"Konrad T. Beyreuther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Konrad Beyreuther","raw_affiliation_strings":["Center for Molecular Biology, The University of Heidelberg, Heidelberg D-69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology, The University of Heidelberg, Heidelberg D-69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047385288","display_name":"Colin Louis Masters","orcid":"https://orcid.org/0000-0003-3072-7940","observed_orcids":["https://orcid.org/0000-0003-3072-7940"]},"institutions":[{"id":"https://openalex.org/I139829854","display_name":"Mental Health Research Institute","ror":"https://ror.org/041684t28","country_code":"AU","type":"facility","lineage":["https://openalex.org/I139829854","https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colin L. Masters","raw_affiliation_strings":["Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I139829854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038374630","display_name":"Ashley Ian Bush","orcid":"https://orcid.org/0000-0001-8259-9069","observed_orcids":["https://orcid.org/0000-0001-8259-9069"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I139829854","display_name":"Mental Health Research Institute","ror":"https://ror.org/041684t28","country_code":"AU","type":"facility","lineage":["https://openalex.org/I139829854","https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Ashley I. Bush","raw_affiliation_strings":["Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129","Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Oxidation Biology, Genetics and Aging Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I139829854"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5038374630"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I139829854","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":12.46,"has_fulltext":false,"cited_by_count":482,"citation_normalized_percentile":{"value":0.99120126,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"274","issue":"33","first_page":"23223","last_page":"23228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8889999985694885},{"id":"https://openalex.org/keywords/metal-chelators","display_name":"metal chelators","score":0.6489999890327454},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.8130000233650208},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":1.0},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.6330000162124634},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":1.0},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dtpa","display_name":"DTPA","score":0.5929999947547913},{"id":"https://openalex.org/keywords/bathocuproine","display_name":"bathocuproine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7181469202041626},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.629677414894104},{"id":"https://openalex.org/C2776785578","wikidata":"https://www.wikidata.org/wiki/Q5134338","display_name":"Clioquinol","level":2,"score":0.6094170212745667},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.5391902923583984},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4935983419418335},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.48034989833831787},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.4323776960372925},{"id":"https://openalex.org/C199164860","wikidata":"https://www.wikidata.org/wiki/Q6822745","display_name":"Metal ions in aqueous solution","level":3,"score":0.43068650364875793},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.420024037361145},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.41769939661026},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4109695851802826},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.4072733223438263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34512102603912354},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32910972833633423},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.3207695782184601},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25009146332740784},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.23019108176231384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22601646184921265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12666115164756775},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10540765523910522}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005029","descriptor_name":"Ethylenediamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010618","descriptor_name":"Phenanthrolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.274.33.23223","doi":"https://doi.org/10.1074/jbc.274.33.23223","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.33.23223","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10438495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10438495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/37369970","doi":null,"is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369970","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J. Biol. Chem.","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.33.23223","doi":"https://doi.org/10.1074/jbc.274.33.23223","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.33.23223","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.550000011920929,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2024283839","display_name":null,"funder_award_id":"5R29AG12686","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2922617312","display_name":"ZINC AND ALZHEIMERS DISEASE PATHOPHYSIOLOGY","funder_award_id":"1r29ag012686-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1590499183","https://openalex.org/W1974069017","https://openalex.org/W1985859760","https://openalex.org/W1996579240","https://openalex.org/W1999206064","https://openalex.org/W2001210466","https://openalex.org/W2018333394","https://openalex.org/W2029427029","https://openalex.org/W2054113864","https://openalex.org/W2060339401","https://openalex.org/W2063281989","https://openalex.org/W2067811915","https://openalex.org/W2070045579","https://openalex.org/W2078151357","https://openalex.org/W2081182167","https://openalex.org/W2083500052","https://openalex.org/W2092887599","https://openalex.org/W2094808560","https://openalex.org/W2101077392","https://openalex.org/W2112488212","https://openalex.org/W2146729934","https://openalex.org/W2411477302","https://openalex.org/W4322701635"],"related_works":["https://openalex.org/W2027608806","https://openalex.org/W1484931242","https://openalex.org/W1480108665","https://openalex.org/W3160076229","https://openalex.org/W2901414017","https://openalex.org/W2001091346","https://openalex.org/W2332512899","https://openalex.org/W2152058429","https://openalex.org/W2070079507","https://openalex.org/W2082308857"],"abstract_inverted_index":{"Zn(II)":[0],"and":[1,54,63,99,105],"Cu(II)":[2],"precipitate":[3],"Abeta":[4,28,37,59,72],"in":[5,30,70,91,112],"vitro":[6],"into":[7],"insoluble":[8],"aggregates":[9],"that":[10,20,82,95],"are":[11],"dissolved":[12],"by":[13,45],"metal":[14,83],"chelators.":[15],"We":[16],"now":[17],"report":[18],"evidence":[19],"these":[21],"biometals":[22],"also":[23,60],"mediate":[24],"the":[25,34,46,86],"deposition":[26],"of":[27,36,48,58,89,109],"amyloid":[29,90],"Alzheimer's":[31,74,92,113],"disease,":[32],"since":[33],"solubilization":[35],"from":[38,73],"post-mortem":[39],"brain":[40,76],"tissue":[41,77],"was":[42],"significantly":[43],"increased":[44],"presence":[47],"chelators,":[49],"EGTA,":[50],"N,N,N',N'-tetrakis(2-pyridyl-methyl)":[51],"ethylene":[52],"diamine,":[53],"bathocuproine.":[55],"Efficient":[56],"extraction":[57],"required":[61],"Mg(II)":[62,104],"Ca(II).":[64],"The":[65],"chelators":[66],"were":[67],"more":[68],"effective":[69],"extracting":[71],"disease":[75],"than":[78],"age-matched":[79],"controls,":[80],"suggesting":[81],"ions":[84,101],"differentiate":[85],"chemical":[87],"architecture":[88],"disease.":[93,114],"Agents":[94],"specifically":[96],"chelate":[97],"copper":[98],"zinc":[100],"but":[102],"preserve":[103],"Ca(II)":[106],"may":[107],"be":[108],"therapeutic":[110],"value":[111]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":27}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}