{"id":"https://openalex.org/W2017542338","doi":"https://doi.org/10.2131/jts.23.supplementiii_561","title":"THIRTEEN-WEEK REPEATED ORAL DOSE TOXICITY STUDY OF ECABAPIDE, A GASTROPROKINETIC DRUG, IN DOGS AND RATS","display_name":"THIRTEEN-WEEK REPEATED ORAL DOSE TOXICITY STUDY OF ECABAPIDE, A GASTROPROKINETIC DRUG, IN DOGS AND RATS","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2017542338","doi":"https://doi.org/10.2131/jts.23.supplementiii_561","mag":"2017542338","pmid":"https://pubmed.ncbi.nlm.nih.gov/9760413"},"language":"en","primary_location":{"id":"doi:10.2131/jts.23.supplementiii_561","doi":"https://doi.org/10.2131/jts.23.supplementiii_561","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementiii_561","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementIII/23_SupplementIII_561/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementIII/23_SupplementIII_561/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005256447","display_name":"Toshimasa Jindo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshimasa JINDO","raw_affiliation_strings":["Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068496725","display_name":"Yuri GENDA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri GENDA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111612894","display_name":"Koji Kakihata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji KAKIHATA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074965316","display_name":"Hiroshi Ohno","orcid":"https://orcid.org/0000-0001-8776-9661","observed_orcids":["https://orcid.org/0000-0001-8776-9661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi OHNO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110028831","display_name":"Yoshihiro Akiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Akiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1267559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"SupplementIII","first_page":"561","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/heinz-bodies","display_name":"Heinz bodies","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hemosiderin-deposition","display_name":"hemosiderin deposition","score":0.972000002861023},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.7450000047683716},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":1.0}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6841347813606262},{"id":"https://openalex.org/C151666851","wikidata":"https://www.wikidata.org/wiki/Q1433921","display_name":"Heinz body","level":3,"score":0.5534404516220093},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5367485284805298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5050225853919983},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5003964900970459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4829806387424469},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.46782439947128296},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.46608632802963257},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45676350593566895},{"id":"https://openalex.org/C2777478355","wikidata":"https://www.wikidata.org/wiki/Q422203","display_name":"Hemosiderin","level":2,"score":0.45629361271858215},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4538693130016327},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4381488561630249},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.41121917963027954},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.4108530282974243},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39637821912765503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39145252108573914},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1283564269542694}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012472","descriptor_name":"Salivation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2131/jts.23.supplementiii_561","doi":"https://doi.org/10.2131/jts.23.supplementiii_561","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementiii_561","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementIII/23_SupplementIII_561/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:9760413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9760413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of toxicological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2131/jts.23.supplementiii_561","doi":"https://doi.org/10.2131/jts.23.supplementiii_561","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementiii_561","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementIII/23_SupplementIII_561/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017542338.pdf","grobid_xml":"https://content.openalex.org/works/W2017542338.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1574634138","https://openalex.org/W2041062914","https://openalex.org/W2050789858","https://openalex.org/W2052753444","https://openalex.org/W2085920481","https://openalex.org/W2086390907","https://openalex.org/W2088886292","https://openalex.org/W2094750024","https://openalex.org/W2258376688","https://openalex.org/W2399152176","https://openalex.org/W2433608088"],"related_works":["https://openalex.org/W2409793110","https://openalex.org/W2415434371","https://openalex.org/W2132804031","https://openalex.org/W3070571708","https://openalex.org/W1967165574","https://openalex.org/W2331190108","https://openalex.org/W2398486060","https://openalex.org/W4244335994","https://openalex.org/W4247545760","https://openalex.org/W2328870309"],"abstract_inverted_index":{"Thirteen-week":[0],"oral":[1],"repeated":[2],"dose":[3,152],"toxicity":[4],"of":[5,17,29,75,147,153],"ecabapide,":[6],"a":[7,141],"gastroprokinetic":[8],"drug,":[9],"was":[10,155],"investigated":[11],"in":[12,24,52,69,77,84,98,138,161,166],"dogs":[13,162],"at":[14,26,58,87,115],"dosage":[15,27],"levels":[16,28],"50,":[18],"175":[19,59,88],"or":[20,33],"600":[21,61,90],"mg/kg,":[22,119],"and":[23,45,72,81,103,110,129,163],"rats":[25],"25,":[30],"100,":[31],"400":[32,116],"1600":[34,118],"mg/kg.":[35,62,91],"In":[36,92],"dogs,":[37],"vomiting,":[38],"aqueous":[39],"salivation,":[40],"body":[41,54,133],"weight":[42],"gain":[43],"inhibition,":[44],"hemolytic":[46,127],"anemia,":[47],"together":[48],"with":[49],"an":[50,130],"increase":[51],"Heinz":[53,132],"formation,":[55],"were":[56,113,124,135],"observed":[57,114,137],"and/or":[60,89,117],"Histological":[63],"examination":[64],"revealed":[65],"enhanced":[66,82],"hemosiderin":[67],"deposition":[68],"the":[70,78,93,145,150],"liver":[71,109],"spleen,":[73],"retention":[74],"erythrocytes":[76],"splenic":[79],"sinus":[80],"erythropoiesis":[83],"bone":[85],"marrow":[86],"rat":[94],"study,":[95],"although":[96],"increases":[97],"serum":[99],"total":[100],"protein,":[101],"albumin":[102],"calcium,":[104],"as":[105,107],"well":[106],"increased":[108,131],"kidney":[111],"weights,":[112],"no":[120],"obvious":[121],"morphological":[122],"changes":[123],"seen.":[125],"The":[126],"anemia":[128],"formation":[134],"not":[136],"rats,":[139],"indicating":[140],"species":[142],"difference.":[143],"On":[144],"basis":[146],"these":[148],"results,":[149],"non-toxic":[151],"ecabapide":[154],"considered":[156],"to":[157],"be":[158],"50":[159],"mg/kg":[160,165],"100":[164],"rats.":[167]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
