{"id":"https://openalex.org/W2017540100","doi":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","title":"Brain neurotransmission in panic disorder","display_name":"Brain neurotransmission in panic disorder","publication_year":1987,"publication_date":"1987-09-01","ids":{"openalex":"https://openalex.org/W2017540100","doi":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","mag":"2017540100","pmid":"https://pubmed.ncbi.nlm.nih.gov/2890266"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0447.1987.tb07746.x","doi":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","pdf_url":null,"source":{"id":"https://openalex.org/S199498439","display_name":"Acta Psychiatrica Scandinavica","issn_l":"0001-690X","issn":["0001-690X","1600-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Psychiatrica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089573141","display_name":"Elias Eriksson","orcid":"https://orcid.org/0000-0002-4128-2046","observed_orcids":["https://orcid.org/0000-0002-4128-2046"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Elias Eriksson","raw_affiliation_strings":["Department of Pharmacology, University of G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089573141"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.7041,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.77142857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"76","issue":"S335","first_page":"31","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panic-disorder","display_name":"panic disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.7390000224113464},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alprazolam","display_name":"alprazolam","score":0.9430000185966492},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9459999799728394},{"id":"https://openalex.org/keywords/panic-anxiety","display_name":"panic anxiety","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neurotransmitter-hypothesis","display_name":"neurotransmitter hypothesis","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2780712732","wikidata":"https://www.wikidata.org/wiki/Q208450","display_name":"Panic","level":3,"score":0.7552343606948853},{"id":"https://openalex.org/C2777529043","wikidata":"https://www.wikidata.org/wiki/Q741713","display_name":"Panic disorder","level":3,"score":0.6391615271568298},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.603150486946106},{"id":"https://openalex.org/C2777196872","wikidata":"https://www.wikidata.org/wiki/Q319877","display_name":"Alprazolam","level":3,"score":0.5975393056869507},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5966757535934448},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5726627707481384},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5540015697479248},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5424488186836243},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5199905037879944},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5104955434799194},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.5059825778007507},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4821002781391144},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4354979991912842},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.42574721574783325},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.41641905903816223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3569701313972473},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17959782481193542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12933093309402466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08344799280166626},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000525","descriptor_name":"Alprazolam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010200","descriptor_name":"Panic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010200","descriptor_name":"Panic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0447.1987.tb07746.x","doi":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0447.1987.tb07746.x","pdf_url":null,"source":{"id":"https://openalex.org/S199498439","display_name":"Acta Psychiatrica Scandinavica","issn_l":"0001-690X","issn":["0001-690X","1600-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Psychiatrica Scandinavica","raw_type":"journal-article"},{"id":"pmid:2890266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2890266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta psychiatrica Scandinavica. Supplementum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W657436150","https://openalex.org/W1964699380","https://openalex.org/W1974290865","https://openalex.org/W1974554583","https://openalex.org/W1980904592","https://openalex.org/W1981112641","https://openalex.org/W1983652770","https://openalex.org/W1984593818","https://openalex.org/W1990901839","https://openalex.org/W1999445315","https://openalex.org/W2007868150","https://openalex.org/W2008461472","https://openalex.org/W2018562021","https://openalex.org/W2022692847","https://openalex.org/W2023517502","https://openalex.org/W2026807595","https://openalex.org/W2026928390","https://openalex.org/W2027381605","https://openalex.org/W2031890290","https://openalex.org/W2039787804","https://openalex.org/W2042061501","https://openalex.org/W2051224229","https://openalex.org/W2051757658","https://openalex.org/W2052981608","https://openalex.org/W2054678161","https://openalex.org/W2059799198","https://openalex.org/W2060051451","https://openalex.org/W2061845384","https://openalex.org/W2069644518","https://openalex.org/W2073940800","https://openalex.org/W2091964096","https://openalex.org/W2101949700","https://openalex.org/W2135810618","https://openalex.org/W2138643911","https://openalex.org/W2306047212","https://openalex.org/W2417582174","https://openalex.org/W2440772142"],"related_works":["https://openalex.org/W1995424129","https://openalex.org/W2413801898","https://openalex.org/W2088071868","https://openalex.org/W1965752072","https://openalex.org/W2302094832","https://openalex.org/W1994263829","https://openalex.org/W2407944143","https://openalex.org/W2139938825","https://openalex.org/W1970093256","https://openalex.org/W2411084256"],"abstract_inverted_index":{"For":[0],"two":[1],"decades":[2],"it":[3,58],"has":[4,122],"been":[5,123],"hypothesized":[6],"that":[7],"schizophrenia":[8],"and":[9,39,98],"depression":[10],"are":[11,29],"related":[12],"to":[13,23,62,72,88,119],"alterations":[14],"in":[15,21,81,93,117,126],"the":[16,32,43,67,73,105,111,127],"activity":[17],"of":[18,35,37,46,69,75,90,102,108,110,129],"specific":[19],"neurotransmitters":[20,71],"brain;":[22],"a":[24],"great":[25],"extent,":[26],"these":[27],"theories":[28],"based":[30],"on":[31],"assumed":[33],"mode":[34,107],"action":[36,109],"antipsychotic":[38],"antidepressant":[40],"drugs.":[41],"With":[42],"available":[44],"knowledge":[45],"how":[47],"panic":[48],"anxiety":[49],"can":[50],"be":[51,79,89,133],"effectively":[52],"treated":[53],"(and":[54],"elicited)":[55],"with":[56],"drugs,":[57],"is":[59],"now":[60],"reasonable":[61],"formulate":[63],"hypotheses":[64],"also":[65,132],"regarding":[66],"contribution":[68],"central":[70],"generation":[74],"panic.":[76],"As":[77],"will":[78,131],"discussed":[80],"this":[82,94,103],"brief":[83],"review,":[84],"three":[85],"substances":[86],"seem":[87],"particular":[91],"importance":[92],"context:":[95],"serotonin,":[96],"noradrenaline":[97],"GABA.":[99],"In":[100],"view":[101],"concept,":[104],"putative":[106],"atypical":[112],"benzodiazepine":[113],"derivative":[114],"alprazolam,":[115],"which":[116],"contrast":[118],"other":[120],"benzodiazepines":[121],"attributed":[124],"effectiveness":[125],"treatment":[128],"panic,":[130],"discussed.":[134]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}