{"id":"https://openalex.org/W2017530266","doi":"https://doi.org/10.1016/s1470-2045(02)00774-x","title":"Population screening for cancer-related germline gene mutations","display_name":"Population screening for cancer-related germline gene mutations","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2017530266","doi":"https://doi.org/10.1016/s1470-2045(02)00774-x","mag":"2017530266","pmid":"https://pubmed.ncbi.nlm.nih.gov/12107021"},"language":"en","primary_location":{"id":"doi:10.1016/s1470-2045(02)00774-x","doi":"https://doi.org/10.1016/s1470-2045(02)00774-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1470-2045(02)00774-x","pdf_url":null,"source":{"id":"https://openalex.org/S116900674","display_name":"The Lancet Oncology","issn_l":"1470-2045","issn":["1470-2045","1474-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109265204","display_name":"Victor R. Grann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor R Grann","raw_affiliation_strings":["Health Outcomes Research, Herbert Irving Comprehensive Cancer Center and Clinical Medicine and Epidemiology, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, NY 10032, USA. vrg2@columbia.edu","Health Outcomes Research, Herbert Irving Comprehensive Cancer Center, and Clinical Medicine and Epidemiology, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University. New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Outcomes Research, Herbert Irving Comprehensive Cancer Center and Clinical Medicine and Epidemiology, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, NY 10032, USA. vrg2@columbia.edu","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Health Outcomes Research, Herbert Irving Comprehensive Cancer Center, and Clinical Medicine and Epidemiology, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University. New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009379894","display_name":"Judith S. Jacobson","orcid":"https://orcid.org/0000-0003-0916-6165","observed_orcids":["https://orcid.org/0000-0003-0916-6165"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith S Jacobson","raw_affiliation_strings":["Clinical Epidemiology, and a member of the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Epidemiology, and a member of the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109265204"],"corresponding_institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":0.2705,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.26248776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"6","first_page":"341","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-screening","display_name":"mass screening","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cancer-susceptibility-genes","display_name":"cancer susceptibility genes","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.8539999723434448},{"id":"https://openalex.org/keywords/screening-criteria","display_name":"screening criteria","score":0.5699999928474426},{"id":"https://openalex.org/keywords/mutation-prevalence","display_name":"mutation prevalence","score":0.7360000014305115},{"id":"https://openalex.org/keywords/penetrance","display_name":"penetrance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6639999747276306},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6940000057220459},{"id":"https://openalex.org/keywords/health-policy","display_name":"health policy","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.7176552414894104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6256764531135559},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.6224579811096191},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5709813833236694},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5644651651382446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5380806922912598},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5252529978752136},{"id":"https://openalex.org/C2776463041","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer screening","level":3,"score":0.4965859055519104},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4464975595474243},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4329718351364136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41149628162384033},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.40850165486335754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33743274211883545},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27533406019210815},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.22742748260498047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18577000498771667},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1470-2045(02)00774-x","doi":"https://doi.org/10.1016/s1470-2045(02)00774-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1470-2045(02)00774-x","pdf_url":null,"source":{"id":"https://openalex.org/S116900674","display_name":"The Lancet Oncology","issn_l":"1470-2045","issn":["1470-2045","1474-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Oncology","raw_type":"journal-article"},{"id":"pmid:12107021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12107021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W11513603","https://openalex.org/W90665978","https://openalex.org/W1512398135","https://openalex.org/W1825553338","https://openalex.org/W1830521991","https://openalex.org/W1843582003","https://openalex.org/W1876964120","https://openalex.org/W1907599506","https://openalex.org/W1944723793","https://openalex.org/W1963802150","https://openalex.org/W1966928100","https://openalex.org/W1975114823","https://openalex.org/W1980540383","https://openalex.org/W1984320393","https://openalex.org/W2008448411","https://openalex.org/W2009074196","https://openalex.org/W2012014972","https://openalex.org/W2014575791","https://openalex.org/W2019428942","https://openalex.org/W2041602034","https://openalex.org/W2043300904","https://openalex.org/W2043973986","https://openalex.org/W2044170626","https://openalex.org/W2045666244","https://openalex.org/W2046809735","https://openalex.org/W2059919283","https://openalex.org/W2063303386","https://openalex.org/W2063324450","https://openalex.org/W2069457741","https://openalex.org/W2085005746","https://openalex.org/W2094145886","https://openalex.org/W2101699473","https://openalex.org/W2103994421","https://openalex.org/W2104836626","https://openalex.org/W2107431207","https://openalex.org/W2109764430","https://openalex.org/W2109882425","https://openalex.org/W2123217683","https://openalex.org/W2129334981","https://openalex.org/W2134680455","https://openalex.org/W2138742383","https://openalex.org/W2139422964","https://openalex.org/W2141647078","https://openalex.org/W2143698296","https://openalex.org/W2144624092","https://openalex.org/W2145362837","https://openalex.org/W2145703637","https://openalex.org/W2145828336","https://openalex.org/W2147047601","https://openalex.org/W2149428338","https://openalex.org/W2167941782","https://openalex.org/W2171439968","https://openalex.org/W2241273108","https://openalex.org/W2266375201","https://openalex.org/W2312752082","https://openalex.org/W2315152040","https://openalex.org/W2326819825","https://openalex.org/W2327951273","https://openalex.org/W2328105863","https://openalex.org/W2330399732","https://openalex.org/W2405878552","https://openalex.org/W2406947676","https://openalex.org/W2474785508","https://openalex.org/W2772971838","https://openalex.org/W3126969879","https://openalex.org/W3203717762","https://openalex.org/W4233063344","https://openalex.org/W4236095073","https://openalex.org/W4237607020","https://openalex.org/W4291382095","https://openalex.org/W4293570160","https://openalex.org/W4300407353","https://openalex.org/W4322702237","https://openalex.org/W6603669329","https://openalex.org/W6685107177","https://openalex.org/W6713414384","https://openalex.org/W7028843752"],"related_works":["https://openalex.org/W2204191358","https://openalex.org/W2145694567","https://openalex.org/W2497044624","https://openalex.org/W2791285296","https://openalex.org/W2302420556","https://openalex.org/W2899720933","https://openalex.org/W2945455908","https://openalex.org/W6888398100","https://openalex.org/W788395759","https://openalex.org/W2591050681"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
