{"id":"https://openalex.org/W2017522419","doi":"https://doi.org/10.1016/0020-7292(93)90340-3","title":"Production of prostacyclin and thromboxane in lupus pregnancies: Effect of small dose of aspirin","display_name":"Production of prostacyclin and thromboxane in lupus pregnancies: Effect of small dose of aspirin","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2017522419","doi":"https://doi.org/10.1016/0020-7292(93)90340-3","mag":"2017522419","pmid":"https://pubmed.ncbi.nlm.nih.gov/8437779"},"language":"en","primary_location":{"id":"doi:10.1016/0020-7292(93)90340-3","doi":"https://doi.org/10.1016/0020-7292(93)90340-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-7292(93)90340-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210216427","display_name":"International Journal of Gynecology & Obstetrics","issn_l":"0020-6695","issn":["0020-6695","0020-7292","1879-3479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecology & Obstetrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073641138","display_name":"Risto Kaaja","orcid":"https://orcid.org/0000-0002-9636-7995","observed_orcids":["https://orcid.org/0000-0002-9636-7995"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R. Kaaja","raw_affiliation_strings":["Department I of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department I of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026640250","display_name":"Heikki A Julkunen","orcid":"https://orcid.org/0000-0003-3369-7492","observed_orcids":["https://orcid.org/0000-0003-3369-7492"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Julkunen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010432416","display_name":"L Viinikka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Viinikka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111917857","display_name":"O. Ylikorkala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Ylikorkala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.968,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.71922739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"2","first_page":"229","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.968999981880188},{"id":"https://openalex.org/keywords/lupus-in-pregnancy","display_name":"lupus in pregnancy","score":0.781000018119812},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.9950000047683716},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prostacyclin-metabolites","display_name":"prostacyclin metabolites","score":0.7559999823570251},{"id":"https://openalex.org/keywords/thromboxane-metabolites","display_name":"thromboxane metabolites","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pregnancy-outcomes","display_name":"pregnancy outcomes","score":0.6600000262260437},{"id":"https://openalex.org/keywords/late-pregnancy","display_name":"late pregnancy","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8533804416656494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8464162349700928},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.7183953523635864},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6762614846229553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6307488679885864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5444338321685791},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.5323662757873535},{"id":"https://openalex.org/C173202427","wikidata":"https://www.wikidata.org/wiki/Q408575","display_name":"Thromboxane-A synthase","level":4,"score":0.514570415019989},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.5048249363899231},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.4700150787830353},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4536728858947754},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3954111635684967},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.20701691508293152},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.0939771831035614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0811496376991272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013931","descriptor_name":"Thromboxanes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017152","descriptor_name":"Antibodies, Antiphospholipid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0020-7292(93)90340-3","doi":"https://doi.org/10.1016/0020-7292(93)90340-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-7292(93)90340-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210216427","display_name":"International Journal of Gynecology & Obstetrics","issn_l":"0020-6695","issn":["0020-6695","0020-7292","1879-3479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecology & Obstetrics","raw_type":"journal-article"},{"id":"pmid:8437779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8437779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics and gynecology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083723902","https://openalex.org/W1998446423","https://openalex.org/W2036281984","https://openalex.org/W2063818399","https://openalex.org/W2042457377","https://openalex.org/W7097607150","https://openalex.org/W2022700560","https://openalex.org/W2120964383","https://openalex.org/W2287781700","https://openalex.org/W2026433108"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"find":[2],"out":[3],"whether":[4],"the":[5,26,34,43,175,190],"tendency":[6],"toward":[7],"poor":[8],"outcome":[9,192],"in":[10,18,120,123,132,143,180],"lupus":[11,75],"pregnancies":[12],"could":[13],"be":[14,200],"explained":[15],"by":[16,66,89],"changes":[17,24],"prostacyclin/thromboxane":[19],"production,":[20],"to":[21,25,32,93,189],"relate":[22],"these":[23,194],"presence":[27,176],"of":[28,37,46,78,116,139,177,193],"antiphospholipid":[29,83,135,158,178],"antibodies,":[30],"and":[31,54,149],"study":[33],"potential":[35],"benefits":[36],"low-dose":[38],"aspirin.":[39,203],"METHODS:":[40],"We":[41,68],"followed":[42,65],"urinary":[44],"output":[45],"prostacyclin":[47,117,168],"metabolites":[48,56],"(6-keto-prostaglandin":[49],"[PG]F1":[50],"alpha,":[51],"2,3-dinor-6-keto-PGF1":[52],"alpha)":[53],"thromboxane":[55,140,164,185,197],"(thromboxane":[57],"B2,":[58],"2,3-dinor-thromboxane":[59],"B2)":[60],"using":[61],"high-pressure":[62],"liquid":[63],"chromatography":[64],"radioimmunoassay.":[67],"studied":[69],"14":[70],"pregnant":[71,108],"women":[72,109],"with":[73,147,202],"systemic":[74],"erythematosus":[76],"(SLE),":[77],"whom":[79],"six":[80],"had":[81],"detectable":[82],"antibodies.":[84,136],"The":[85,114,137],"patients":[86,125,145,182],"were":[87,160],"randomized":[88],"a":[90],"computerized":[91],"program":[92],"receive":[94],"either":[95],"50":[96],"mg":[97],"aspirin":[98],"daily":[99],"(six":[100],"women)":[101],"or":[102],"placebo":[103],"(eight":[104],"women).":[105],"Nine":[106],"healthy":[107],"served":[110],"as":[111],"controls.":[112],"RESULTS:":[113],"production":[115,138],"was":[118,127,141,152],"normal":[119],"early":[121],"pregnancy":[122],"SLE":[124,144,181],"but":[126],"reduced":[128],"during":[129],"late":[130],"gestation":[131],"those":[133],"without":[134,166],"increased":[142],"compared":[146],"controls,":[148],"this":[150],"increase":[151],"highest":[153],"(two-to":[154],"threefold":[155],"rise)":[156],"when":[157],"antibodies":[159,179],"detectable.":[161],"Aspirin":[162],"eliminated":[163,201],"dominance":[165,198],"affecting":[167],"production.":[169],"CONCLUSION:":[170],"These":[171],"data":[172],"suggest":[173],"that":[174],"may":[183],"trigger":[184],"dominance,":[186],"possibly":[187],"contributing":[188],"adverse":[191],"pregnancies.":[195],"This":[196],"can":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}