{"id":"https://openalex.org/W2017522331","doi":"https://doi.org/10.1002/eji.1830221014","title":"Genetics of nonspecific immunity: I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness","display_name":"Genetics of nonspecific immunity: I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2017522331","doi":"https://doi.org/10.1002/eji.1830221014","mag":"2017522331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1396963"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830221014","doi":"https://doi.org/10.1002/eji.1830221014","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830221014","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040419754","display_name":"Olga M. Iba\u00f1ez","orcid":"https://orcid.org/0000-0002-2672-4758","observed_orcids":["https://orcid.org/0000-0002-2672-4758"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Olga M. Ibanez","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo","Laboratorio de Immunogenetica, Instituto Butantan, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086036716","display_name":"Claude Stiffel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Stiffel","raw_affiliation_strings":["Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042370367","display_name":"Orlando Garcia Ribeiro","orcid":"https://orcid.org/0000-0003-2117-2402","observed_orcids":["https://orcid.org/0000-0003-2117-2402"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Orlando G. Ribeiro","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080512478","display_name":"Wafa Koury Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]},{"id":"https://openalex.org/I4210116822","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210116822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wafa K. Cabrera","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris","Supported by a fellowship of FAPESP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Supported by a fellowship of FAPESP","institution_ids":["https://openalex.org/I4210116822"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Solange Massa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]},{"id":"https://openalex.org/I4210116822","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210116822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Solange Massa","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris","Supported by a fellowship of FAPESP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Supported by a fellowship of FAPESP","institution_ids":["https://openalex.org/I4210116822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038897699","display_name":"Marcelo De Franco","orcid":"https://orcid.org/0000-0002-0417-8215","observed_orcids":["https://orcid.org/0000-0002-0417-8215"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo De Franco","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035151105","display_name":"Osvaldo Augusto Sant\u2019Anna","orcid":"https://orcid.org/0000-0003-1746-9465","observed_orcids":["https://orcid.org/0000-0003-1746-9465"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Osvaldo A. Sant'Anna","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris","Supported in part by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Supported in part by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico","institution_ids":["https://openalex.org/I11385950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010859615","display_name":"Claude Decreusefond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Decreusefond","raw_affiliation_strings":["Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030098338","display_name":"Denise Mouton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denise Mouton","raw_affiliation_strings":["Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sao Paulo and Service d'Immunoge\u0301ne\u0301tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Sao Paulo and Service d'Immunog\u00e9n\u00e9tique, CNRS URA 1413, Institut Curie, Section de Biologie, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102402555","display_name":"Maria Siqueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Siqueira","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris","Supported in part by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Supported in part by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico","institution_ids":["https://openalex.org/I11385950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090898134","display_name":"G Biozzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Guido Biozzi","raw_affiliation_strings":["Laboratorio de Immunogenetica, Instituto Butantan, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Immunogenetica, Instituto Butantan, Paris","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090898134"],"corresponding_institution_ids":["https://openalex.org/I2800423888"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"22","issue":"10","first_page":"2555","last_page":"2563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.20350000262260437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonspecific-immunity","display_name":"non-specific immunity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/acute-inflammatory-response","display_name":"acute inflammatory response","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mouse-lines","display_name":"mouse lines","score":0.4480000138282776},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/additive-genetic-effects","display_name":"additive genetic effects","score":0.6520000100135803},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.73907071352005},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6567457914352417},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5279102921485901},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5062167048454285},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.47904860973358154},{"id":"https://openalex.org/C12558332","wikidata":"https://www.wikidata.org/wiki/Q995745","display_name":"Selective breeding","level":2,"score":0.4777209460735321},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47102364897727966},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4156607389450073},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.412497341632843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4064452648162842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3864506781101227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36652088165283203},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08659780025482178},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005122","descriptor_name":"Exudates and Transudates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830221014","doi":"https://doi.org/10.1002/eji.1830221014","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830221014","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1396963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1396963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W37442720","https://openalex.org/W172277614","https://openalex.org/W284173548","https://openalex.org/W593114776","https://openalex.org/W794061976","https://openalex.org/W1525986469","https://openalex.org/W1581326991","https://openalex.org/W1619595067","https://openalex.org/W1937436107","https://openalex.org/W2032165441","https://openalex.org/W2032372207","https://openalex.org/W2035235733","https://openalex.org/W2063090474","https://openalex.org/W2065588990","https://openalex.org/W2070215071","https://openalex.org/W2106543443","https://openalex.org/W2124353362","https://openalex.org/W2128635872","https://openalex.org/W2130684966","https://openalex.org/W2134823756","https://openalex.org/W2140643400","https://openalex.org/W2142090875","https://openalex.org/W2144278714","https://openalex.org/W2153099100","https://openalex.org/W2176220887","https://openalex.org/W2177594905","https://openalex.org/W2395927714","https://openalex.org/W2414234533","https://openalex.org/W2587724197","https://openalex.org/W2743872174"],"related_works":["https://openalex.org/W1937436107","https://openalex.org/W7120566690","https://openalex.org/W2339244097","https://openalex.org/W2061267128","https://openalex.org/W2160675598","https://openalex.org/W1559610984","https://openalex.org/W2003656441","https://openalex.org/W4313311505","https://openalex.org/W2052451713","https://openalex.org/W2017986032"],"abstract_inverted_index":{"The":[0,43,70,82,111,139,160,181,194],"genetic":[1],"regulation":[2],"of":[3,13,22,30,50,55,94,98,108,142,170,183,187,208,219],"acute":[4],"inflammatory":[5,35,220],"reaction":[6,36],"(AIR)":[7],"was":[8,45,88,119,150],"studied":[9],"by":[10,47,60,90,105],"the":[11,25,33,61,68,91,127,134,146,168,188,203,214],"method":[12],"bidirectional":[14],"selective":[15,101],"breeding,":[16],"used":[17],"to":[18,113,162,172,185],"produce":[19],"a":[20,28,51,78,122],"line":[21,29,137,149,191],"mice":[23,31],"giving":[24,32],"maximal":[26],"and":[27,39,58,63,76,100,130,152,156,205,210],"minimal":[34],"(AIR":[37],"max":[38,129,148],"AIR":[40,44,124,128,135,147,189],"min,":[41],"respectively).":[42],"triggered":[46],"subcutaneous":[48],"injection":[49],"neutral":[52],"substrate":[53],"(suspension":[54],"polyacrylamide":[56],"microbeads),":[57],"measured":[59],"leukocyte":[62],"serum":[64],"protein":[65,157],"accumulation":[66],"in":[67,115,126,133,145],"exudate.":[69],"two":[71],"parameters":[72],"are":[73],"positively":[74],"correlated":[75],"present":[77],"normal":[79],"frequency":[80],"distribution.":[81],"highly":[83,120],"genetically":[84],"heterogeneous":[85],"foundation":[86],"population":[87],"produced":[89],"equipoised":[92],"intercrossing":[93],"eight":[95],"inbred":[96],"strains":[97],"mice,":[99],"breeding":[102],"carried":[103],"out":[104],"assortative":[106],"matings":[107],"extreme":[109],"phenotypes.":[110],"response":[112,161,184],"selection":[114,163,186],"11":[116],"consecutive":[117],"generations":[118],"asymmetrical:":[121],"marked":[123],"increase":[125],"no":[131],"change":[132],"min":[136,190],"occurred.":[138],"mean":[140],"value":[141],"realized":[143],"heritability":[144],"0.26":[151],"0.18":[153],"for":[154,201,212],"cell":[155],"concentrations,":[158],"respectively.":[159],"must":[164],"have":[165],"resulted":[166],"from":[167],"interaction":[169],"seven":[171],"nine":[173],"independent":[174],"gene":[175],"loci":[176],"endowed":[177],"with":[178],"additive":[179],"effects.":[180],"lack":[182],"is":[192],"discussed.":[193],"large":[195],"inter-line":[196],"difference":[197],"opens":[198],"new":[199],"possibilities":[200],"studying":[202],"biochemistry":[204],"molecular":[206],"genetics":[207],"inflammation,":[209],"also":[211],"investigating":[213],"beneficial":[215],"or":[216],"detrimental":[217],"effect":[218],"responses.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
